Novosti
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This journal is indexed in Scopus |
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Year 2007 Vol. 15 No 4
ORIGINAL INVESTIGATIONS
MARKAUTSAN P.V., BAYESHKO A.A., ARCHAKOVA L.I.
VEIN INTIMA CHANGES IN BLOOD FLOW RETARDATION IN THE EXPERIMENT
Blood flow retardation in the early period (the first minutes – days) causes intima damage due to hypoxia and transendothelial leukocyte migration. Leukocytes have been located along the inner vein coat by the 5th minute of the experiment, during the 15th minute they are massively infiltrating its wall. Swelling and focal disturbance of endothelium integrity (mainly of cytoplasm cell part) are observed as well as inner elastic membrane fragmentation. The number of microvilli increases chiefly on the endotheliocytes apical surface. The collagenous fibers content increases in the subendothelial layer. In several cases formation of «microthrombi», consisting of single leukocytes and thrombocytes, adhesived to the vein luminal surface, takes place. At the same time adaptation processes occur actively in intima, aimed to minimize the damages and to restore its ultra structure.
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