Year 2018 Vol. 26 No 5

CASE REPORTS

I.V. RESHETOV, I.I. BYKOV, A.A. SHEVALGIN, YU.S. KUROCHKINA, T.P. NEKRASOVA, M.S. MIKEROVA

SYNCHRONOUS PRIMARY-MULTIPLE MALIGNANT TUMOR: BIFENOTYPIC SYNONASAL SARCOMA AND COLORECTAL CANCER

I.M. Sechenov First Moscow State Medical University, Moscow,
The Russian Federation

Primary-multifocal malignant tumors hold a specific place in oncology. Present case report describes the combination of two neoplastic processes with different anatomic localization, the analogues to which have not been found either in the domestic literature or foreign sources.
The article presents the case of a synchronous primary-multiple malignant neoplasm malignant tumor from the membranes of the peripheral nerves of the nasal cavity with expansion into the right maxillary sinus, the cells of the ethmoidal sinus 2bN0M0 and moderately differentiated adenocarcinoma of the sigmoid colon 4N0M0. Physical examination and positron emission tomography combined with the computed tomography confirmed a hypervascular tumor of the posterior cells of the ethmoidal sinus and a nasal cavity without hypermetabolism and the circular tumor of the sigmoid colon with hypermetabolism. Taking into account the primary-multiple character of the lesion and the clinic of intestinal obstruction, a tactic of the treatment was a combined surgery the removal of the neoplasm of the nasal cavity with resection of the right maxillary sinus with microsurgical technique and a reconstructive-plastic component using a coronary access, laparotomy, resection of the sigmoid colon, lymphadenectomy. The chosen treatment allowed eliminating both of the tumors in a short time and moving on to a further stage of treatment. The patient is under the supervision, there is no recurrence of the disease at the moment.

Keywords: synonasal sarcoma, primary-multiple malignant tumors, colorectal cancer
p. 629-635 of the original issue
References
  1. Chissov VI, Starinskii VV, Petrova GV, red. Zlokachestvennye novoobrazovaniia v Rossii v 2011 g. (zabolevaemost i smertnost). Moscow, RF: MNIOI im PA Gertsena; 2013. 289 p. http://www.oncology.ru/service/statistics/malignant_tumors/2011.pdf (in Russ.)
  2. Wong WJ, Lauria A, Hornick JL, Xiao S, Fletcher JA, Marino-Enriquez A. Alternate PAX3-FOXO1 oncogenic fusion in biphenotypic sinonasal sarcoma. Genes Chromosomes Cancer. 2016 Jan;55(1):25-29. doi: 10.1002/gcc.22295
  3. Huang SC, Ghossein RA, Bishop JA, Zhang L, Chen TC, Huang HY, Antonescu CR. Novel PAX3-NCOA1 fusions in biphenotypic sinonasal sarcoma with focal rhabdomyoblastic differentiation. Am J Surg Pathol. 2016 Jan;40(1):51-59. doi: 10.1097/PAS.0000000000000492
  4. Wang X, Bledsoe KL, Graham RP, Asmann YW, Viswanatha DS, Lewis JE, Lewis JT, Chou MM, Yaszemski MJ, Jen J, Westendorf JJ, Oliveira AM. Recurrent PAX3-MAML3 fusion in biphenotypic sinonasal sarcoma. Nat Genet. 2014 Jul;46(7):666-68. doi: 10.1038/ng.2989
  5. Rooper LM, Huang SC, Antonescu CR, Westra WH, Bishop JA. Biphenotypic sinonasal sarcoma: an expanded immunoprofile including consistent nuclear β-catenin positivity and absence of SOX10 expression. Hum Pathol. 2016 Sep;55:44-50. doi: 10.1016/j.humpath.2016.04.009
  6. Fritchie KJ, Jin L, Wang X, Graham RP, Torbenson MS, Lewis JE, Rivera M, Garcia JJ, Schembri-Wismayer DJ, Westendorf JJ, Chou MM, Dong J, Oliveira AM. Fusion gene profile of biphenotypic sinonasal sarcoma: an analysis of 44 cases. Histopatho-logy. 2016 Dec;69(6):930-36. doi: 10.1111/his.13045
  7. Lin Y, Liao B, Han A. Biphenotypic sinonasal sarcoma with diffuse infiltration and intracranial extension: a case report. Int J Clin Exp Pathol. 2017; 10(12):11743-46. http://www.ijcep.com/files/ijcep0062441.pdf
  8. Cannon RB, Wiggins RH 3rd, Witt BL, Dundar Y, Johnston TM, Hunt JP. Imaging and outcomes for a new entity: low-grade sinonasal sarcoma with neural and myogenic features. J Neurol Surg Rep. 2017 Jan;78(1):e15-e19. doi: 10.1055/s-0037-1598198
  9. Lewis JT, Oliveira AM, Nascimento AG, Schembri-Wismayer D, Moore EA, Olsen KD, Garcia JG, Lonzo ML, Lewis JE. Low-grade sinonasal sarcoma with neural and myogenic features: a clinicopathologic analysis of 28 cases. Am J Surg Pathol. 2012 Apr;36(4):517-25. doi: 10.1097/PAS.0b013e3182426886
  10. Haraldsdottir S, Einarsdottir HM, Smaradottir A, Gunnlaugsson A, Halfdanarson TR. Colorectal cancer review. Laeknabladid. 2014 Feb;100(2):75-82. http://europepmc.org/abstract/MED/24639430ED/24639430 [Article in Icelandic]
Address for correspondence:
119991, Russian Federation,
Moscow, Trubetskaya str., 8-2,
I.M. Sechenov First Moscow
State Medical University,
Department of Public Health
And Healthcare Named after N.A. Semashko,
Tel. +7 915 225 86 89,
e-mail: masha-med@mail.ru,
Maria S. Mikerova
Information about the authors:
Reshetov Igor V., MD, Academician of RAS, Professor, Head of the Department of Oncology and Reconstructive Surgery, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
https://orcid.org/0000-0002-0909-6278
Bykov Igor I., PhD, Oncologist, Oncologic Surgery Unit of Combined Treatment Methods, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
https://orcid.org/0000-0001-8391-8885
Shevalgin Alexandr A., Oncologist, Oncologic Surgery Unit of Combined Treatment Methods, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
https://orcid.org/0000-0002-7045-5540
Kurochkina Juliya S., Oncologist, Oncologic Surgery Unit of Combined Treatment Methods, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
https://orcid.org/0000-0002-3556-2703
Nekrasova Tatiyana P., PhD, Associate Professor of the Department of Pathological Anatomy named after Academician A.I. Strukov, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
https://orcid.org/0000-0001-6376-9392
Mikerova Maria S., PhD, Associate Professor of the Department of Public Health and Healthcare named after N.A. Semashko, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
https://orcid.org/0000-0003-2718-1895
Contacts | ©Vitebsk State Medical University, 2007-2023