Novosti
Khirurgii

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Year 2016 Vol. 24 No 6

GENERAL & SPECIAL SURGERY

V.S. DERCKACHEV, S.A. ALEKSEJEV, Z.A. IBRAGIMOVA, M.P. POTAPNEV, V.N. BORDAKOV, A.V. HONCHARICK, S.E. SEMERICHINA, L.V. KARTUN

IMMUNOLOGICAL PREDICTORS OF EARLY POSTOPERATIVE PYO-INFLAMMATORY COMPLICATIONS IN PATIENTS WITH LONG BONE FRACTURES

EE "Belarusian State Medical University",
Minsk.
The Republic of Belarus

Objectives. To identify the predictors of early postoperative complications based on biochemical and immunological parameters of patient’ peripheral blood.
Methods. The patients (n=38) operated on due to fractures of long tubular bone were divided into two groups depending on the occurrence of pyo-inflammatory complications in the early incisional period (10 days). In the first group of patients (n=23) no complications was observed and in the second (n=15) pyo-inflammatory complications developed. Peripheral blood samples were collected prior and in 3, 5 and 10 days after the operation. Some biochemical (superoxiddismutase, catalase, malonic dialdehyde, calprotectin, procalcitonin, C-reactive protein/CRP) and immunological parameters (CD3+, CD4+, CD8+ Ò lymphocytes; immunoglobulins IgA, IgE, IgG, IgM; interleukin-1β/IL-1β, IL-6, IL-4, IL-8, IL-10, tumor necrosis factor-α, interferon-γ) were evaluated.
Results. The pyo-inflammatory complications (n=15) have developed in the incisional period up to 10 days. Those patients in comparison the patients without any complications in the preoperative period demonstrated an blood level of CRP, IL-6, IL-10, procalcitonin, CD3+CD4+ T lymphocytes and decreased level of IgE. 3 days after the operation the reliably high values of IL-6, IL-10, CD3+CD4+T cells retained, increase of IgG and IgM in the blood serum and reduction of IgE level are considered to be an additional predictor of pyo-inflammatory complications.
Conclusion. Within the preoperative period predictors of infectious markers in patients after the operation of osteosynthesis are an elevated level of blood CRP, IL-6, IL-10, procalcitonin and reduced level of IL-6, in 3 days after the operation an elevated level IL-10, CD3+CD4+ T lymphocytes, serum IgG, IgM and decreased level of IgE were observed.

Keywords: fractures of long tubular bones, operation, pyo-inflammatory complications, peripheral blood, laboratory assessment, additional predictor, preoperative period
p. 561-567 of the original issue
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Address for correspondence:
220116, Republic of Belarus, Minsk,
Dzerzhinsky pr. 83,
EE "Belarusian State Medical University",
department of general surgery.
Tel.: 375 172 20-24-70
E-mail: vsderkachev@mail.ru
Derkachev Viktor Sergeevich
Information about the authors:
Derkachev V.S. PhD, Ass. Professor of the department of the general surgery, EE
"Belarusian State Medical University",
Aleksejev S.A. MD, Professor, Head of the department of general surgery, EE
"Belarusian State Medical University".
Ibragimova Z.A. PhD (Biology), Head of the laboratory of biochemical research methods, EE "Belarusian State Medical University".
Potapnev M.P. MD, Professor, Chief researcher of the laboratory of biochemical methods of investigation, EE "Belarusian State Medical University".
Bordakov V.N. MD, Professor of the department of general surgery, EE "Belarusian State Medical University".
Honcharick A.V. Senior researcher of the laboratory of biochemical methods of investigation, EE "Belarusian State Medical University".
Semerichina S.E. PhD, Freelance researcher of the laboratory of biochemical methods of investigation, EE "Belarusian State Medical University".
Kartun L.V. Senior researcher of the laboratory laboratory of biochemical methods of investigation, EE "Belarusian State Medical University".
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