Year 2015 Vol. 23 No 6

REVIEWS

A.A. TRETYAKOV1, S.V. PETROV1, A.N. NEVEROV1, A.F. SHCHETININ1

TREATMENT OF PURULENT WOUNDS

SBEE HPE "Orenburg State Medical University"1
The Russian Federation

The number of patients with acute purulent diseases of the soft tissues hasn’t reduced and tends to rise, accounting for 35-40% of all surgical patients. The success of the surgical treatment of acute purulent diseases of soft tissues depends on radical surgical aids, performed with adequate anesthesia. Drainage of wound fluid is an factor important to successful wound healing in the incisional period. The use of antibiotics is included in a comprehensive treatment of patients with acute purulent surgical infection. The development of current methods of active treatment is related to the revision of the main points of the classical incision-drainage method and changing the very nature of the operation itself. They envisage a targeted radical surgery in the site of supportive focus to provide the effective and adequate drainage so as completely different, more aggressive therapy of purulent wounds in the inflammatory and regeneration phases. Any drainage system requires some special conditions. The necessity for early and rapid closing of purulent wound led to the search and creation of conditions for sutures and skin plasty. A new perspective way to overcome antibiotic resistance is considered to use probiotics. Another new direction in solving the issue of the treatment of chronic inflammatory processes of different localization is the inclusion of neuropeptides such as hypothalamic nanopeptid (oxytocin) in a comprehensive treatment.

Keywords: purulent wounds, surgical treatment, treatment tactics, drainage, resistance to antibiotics, probiotics, neuropeptides
p. 680-687 of the original issue
References
  1. Koreiba KA, Gaziev AR. Khirurgicheskie infektsionnye porazheniia kozhi i miagkikh tkanei. Lechenie dlitel'no nezazhivaiushchikh ran [Surgical infections of the skin and soft tissues. Treatment of persistent wounds]. Monografiia. Kazan', RF: Otechestvo; 2011. 253 p.
  2. Kochorov OT, Chyngyshpaev ShM, Tursunov RA. Sovremennoe sostoianie voprosa khirurgicheskogo lecheniia ran i ranevoi infektsii [The current state of the problem of surgical treatment of wounds and wound infections]. Vestn Avitsenny. 2011;(1):22-25.
  3. Beschastnov VV, Maramokhin VN. Novyi sposob aktivnogo lecheniia gnoinykh ran miagkikh tkanei [A new way of active treatment of purulent wounds of soft tissues]. Izvestiia Vysshikh Uch Zav. Povolzhskii region. Med Nauki. 2010;(3):59-67.
  4. Blatun LA. Mestnoe medikamentoznoe lechenie ran. Problemy i novye vozmozhnosti ikh resheniia [Local medical treatment of wounds. Challenges and opportunities of their solution]. Consilium Medicum. Khirurgiia. 2007;(1):9-16.
  5. Iakovlev SV. Gospital'nye infektsii, vyzvannye gramotritsatel'nymi mikroorganizmami: klinicheskoe znachenie i sovremennye vozmozhnosti terapii [Hospital infections caused by gram-negative microorganisms: clinical significance and current treatment options]. Infektsii i Antimikrobnaia Terapiia 2007;6(4):133-36
  6. Proud D, Bruscino Raiola F, Holden D, Paul E, Capstick R, Khoo A. Are we getting necrotizing soft tissue infections right? A 10-year review. ANZ J Surg. 2014 Jun;84(6):468-72. doi: 10.1111/ans.12412.
  7. Motorina IG, Kulikov LK, Meleshko TI. Sovremennye predstavleniia o fizioterapevticheskikh sposobakh lecheniia khronicheskikh ran [Modern views on physical therapy methods for the treatment of chronic wounds]. Sib Med Zhurn. 2012;114(7):8-11.
  8. Blatun LA. Mestnoe medikamentoznoe lechenie ran [Local medical treatment of wounds]. Khirurgiia. Zhurn im NI Pirogova. 2011;(4):51-59.
  9. Lutsevich OE, Tamrazova OB, Shikunova AIu, Pleshkov AS, Ismailov GIO, Vorotilov IuV, Tolstykh PI. Sovremennye vzgliady na patogenez i lechenie gnoinykh ran [Current views on the pathogenesis and treatment of purulent wounds]. Khirurgiia. Zhurn im NI Pirogova. 2011;(5):72-77.
  10. The Sanford guide to antimicrobial therapy. Thirtythird edition. Gilbert O,/Ed. Sande M. Antimicrob Therapy Inc. 2003.
  11. Privol'nev VV, Karakulina EV. Osnovnye printsipy mestnogo lecheniia ran i ranevoi infektsii [The basic principles of local treatment of wounds and wound infections]. Klin Mikrobiol Antimikrob Khimioter. 2011;13(3):214-22.
  12. Beizerov IuM, Loban EK, Strunovich AA, Shiriaev AV, Infarovich SA. Khirurgicheskoe lechenie ran: sovremennye podkhody [Surgical treatment of wounds: current approaches]. Khirurgiia. Vostoch Evropa. 2012;3(3):286-87.
  13. Alfonso JL, Pereperez SB, Canoves JM, Martinez MM, Martinez IM, Martin-Moreno JM.Are we really seeing the total costs of surgical site infections? A Spanish study. Wound Repair Regen. 2007 Jul-Aug;15(4):474-81.
  14. Abaev IK. Spravochnik khirurga. Rany i ranevaia infektsiia [Directory surgeon. Wounds and wound infection]. Feniks. 2005; 427 p.
  15. Kazarian NS, Kozlov KK, Bykov AIu, Kokorin SV, Viktorov SI. Lechenie patsientov s gnoinymi ranami putem primeneniia aspiratsionno-protochno-promyvnogo drenazha novoi konstruktsii [Treatment of patients with purulent wounds through the use of flow-aspiration-washing drainage of a new design]. Vestn Ross Akad Med Nauk. 2013;(12):64-68.
  16. Zak VI, Kurlaev PP. Mestnoe lechenie postin'ektsionnykh abstsessov kombinatsiei oksitotsina i antibiotikov [Local treatment of postinjection abscesses combination of oxytocin and antibiotics]. Khirurgiia. Zhurn im NI Pirogova. 1985;(5):112-15.
  17. Kurbangaleev SM. Gnoinaia infektsiia v khirurgii [Purulent infection in surgery]. Moscow, USSR: Meditsina; 1985. 272 p.
  18. Andreev AA, Frolov RN, Bugrimov DI, Karpukhin AG. Lechenie ran s pomoshch'iu applikatsionno-inektsionnogo vvedeniia gidrolizata kollagena [Wound healing with the help of the applicator-injecting collagen hydrolyzate]. Glob Nauch Potentsial. 2013;6(27):5-9.
  19. Smotrin SM, Oslavskii AI, Kuznetsov AG, Grakovich PN. Sorbtsionno-drenazhnoe ustroistvo v lechenii gnoinykh ran i abstsessov miagkikh tkanei [Sorption-drainage device in the treatment of purulent wounds and abscesses of soft tissues]. Khirurgiia. Vostoch Evropa. 2012;(3):308-309.
  20. Kuzin MI, Kostiuchenok BM, Kolker II. Rany i ranevaia infektsiia [Wounds and wound infection]. Moscow, RF: Meditsina; 1991. 687 p.
  21. Kanshin N.N. Printsipy zakrytogo aspiratsionno-promyvnogo lecheniia zagriaznennykh i nagnoivshikhsia ran [The principles of the closed aspiration-washing treatment of contaminated and festering wounds]. Khirurgiia.1989;(6):112-15.
  22. Berkutov AN./red. Uchebnik voenno-polevoi khirurgii [Textbook military field surgery]. Uchebnik. 2-e izd dop i ispr. Leningrad, USSR: 1973. 569 p.
  23. Khalilov MA. Voprosy optimizatsii mestnogo lecheniia gnoinykh ran [Problems of optimization of local treatment of purulent wounds]. Kursk Nauchn-Prakt Vestn Chelovek i ego Zdorov'e. 2009;(3):31-37.
  24. Gostishchev VK. Operativnaia gnoinaia khirurgiia [Operative purulent surgery]. Moscow, RF: Meditsina; 1996. 416 p.
  25. Yao K, Bae L, Yew WP.Post-operative wound management. Aust Fam Physician. 2013 Dec;42(12):867-70.
  26. Zagirov UZ, Isaev UM, Salikhov MA. Ozono-magnitoforez v lechenii gnoinoi rany [Ozone-magnetophoresis in the treatment of purulent wounds]. Vestn Novykh Med Tekhnologii. 2007;14(3):207-208.
  27. Larichev AB, Antoniuk AV, Kuz'min BC. Vakuum-terapiia v kompleksnom lechenii gnoinykh ran. [Vacuum therapy in complex treatment of purulent wounds]. Khirurgiia. Zhurn im NI Pirogova. 2008;(6):22-26.
  28. Glukhov AA, Skorynin OS. Eksperimental'noe obosnovanie primeneniia programmiruemoi magnitoterapii v lechenii ran miagkikh tkanei [Experimental substantiation of application programmable magnetic therapy in the treatment of soft tissue injuries]. Vestn Eksperim i Klin Khirurgii. 2009;2(4):305-15.
  29. Glukhov AA, Lobtsov AV, Alekseeva NT. Optimizatsiia lecheniia ran miagkikh tkanei s primeneniem poliarizovannogo oblucheniia i gidropressivnykh tekhnologii [Optimization of the treatment of soft tissue wounds using polarized light and hydropressive technologies]. Sistem Analiz i Upr v Biomed Sistemakh. 2010;9(1):253-56.
  30. Obolenskii VN, Semenistyi AIu, Nikitin VG, Sychev DV. Vakuum-terapiia v lechenii ran i ranevoi infektsii [Vacuum therapy in the treatment of wounds and wound infections]. Russ Med Zhurn. 2010;18(17):1064-72.
  31. Derbenev VA, Nabiev AF, Steshin AV, Kuleshov IIu. Krainevysokochastotnaia i lazernaia terapiia v lechenii bol'nykh s gnoinymi ranami miagkikh tkaneiiu [High-frequency and laser therapy in the treatment of patients with purulent wounds of soft tissues]. Lazer Meditsina. 2010;14(3):8-11.
  32. Kuleshov SE. Anaerobnaia klostridial'naia i neklostridial'naia infektsiia v khirurgii [Anaerobic clostridial and non-clostridial infection in the surgery]. Moscow, RF: Meditsina. 1993.
  33. Blueman D, Bousfield C. The use of larval therapy to reduce the bacterial load in chronic wounds. J Wound Care. 2012 May;21(5):244-53.
  34. Izmailov SG, Botiakov AA, Botiakov AG, Artifeksova AA, Iunusova KE. Poluotkrytyi sposob lecheniia gnoinykh ran miagkikh tkanei [Semi-closed method for the treatment of purulent wounds of soft tissues]. Sovr Tekhnol v Meditsine. 2010;(1):56-59.
  35. Gostishchev VK, Muliev LF, Nikolaev AB. Polimernyi sorbent regenkur v lechenii gnoinykh ran [Polymeric sorbents regenkur in the treatment of purulent wounds]. Khirurgiia. 1993;(11):3-6.
  36. Mokhov EM, Armasov AR, Amrullaev GA, Pazhetnev AG. Ispol'zovanie biologicheskikh svoistv perftorana pri mestnom lechenii gnoinykh ran [Using biological properties perftorana the topical treatment of purulent wounds]. Ross Med Zhurn. 2011;(3):10-13.
  37. Mokhov EM, Vorob'ev SI, Armasov AR. Primenenie ozonirovannogo perftorana pri lechenii gnoinykh ran [The use of ozonated perftorana in the treatment of septic wounds]. Vestn Eksperim i Klin Khirurgii. 2012;5(2):324-29.
  38. Magomedov AR. K voprosu o lechenii gnoinykh ran [On the question of treatment of purulent wounds]. Vestn Orenburg Gos Un-tet. 2011;6(135):308-309.
  39. Shin FE, Starichkov IG, Rybasov PI, Vorotilov IV, Mamedov NI, Shirinskii VG. Novoe v lechenii gnoinykh ran [New in the treatment of purulent wounds]. Moskov Khir Zhurn. 2011;(5):51-54.
  40. Wilson AP, Gibbons C, Reeves BC, Hodgson B, Liu M, Plummer D, Krukowski ZH, Bruce J, Wilson J, Pearson A. Surgical wound infection as a performance indicator: agreement of common definitions of wound infection in 4773 patients. BMJ. 2004 Sep 25;329(7468):720.
  41. Lipsky BA. Medical treatment of diabetic foot infections. Clin Infect Dis. 2004 Aug 1;39 Suppl 2:S104-14.
  42. Kozlov RS. Nozokomial'nye infektsii: epidemiologiia, patogenez, profilaktika, kontrol' [Nosocomial infections: epidemiology, pathogenesis, prevention, control]. Klin Mikrobiol i Antimikrob Khimioterapiia. 2000;(2)1:16-30.
  43. Sidorenko SV, Semina NA, Kozlov RS, Stetsiuk OU, Strachunskii LS, Stoliarova LG, Grudinina SA, Rezvan SP, Ved'mina EA, Vlasova IV, Eidel'shtein MV, Sereda ZS. Opredelenie chuvstvitel'nosti mikroorganizmov k antibakteral'nym preparatam [Determination of the sensitivity of microorganisms to antibiotics]. Klin Mikrobiol Antimikrob Khimioter. 2004;6(4):306-59.
  44. Verdú Soriano J, Nolasco Bonmati A. [ALEA study. Treatment of chronic wounds infected by the application of silver dressings nanocrystalline combined with dressings hydrocellular]. Rev Enferm. 2010Oct;33(10):6-14. [Article in Spanish].
  45. Shi E, Shofler D.Maggot debridement therapy: a systematic review. Br J Community Nurs. 2014 Dec;Suppl Wound Care:S6-13. doi: 10.12968/bjcn.2014.19.Sup12.S6.
  46. Slepykh NI, Stadnikov AA, Tret'iakov AA. Profilaktika i lechenie posleoperatsionnykh ranevykh infektsii probiotikom sporobakterinom [Prevention and treatment of post-operative wound infections probiotic Sporobacterin]. Posobie dlia vrachei. Orenburg; 2001. 39 p.
  47. Nikitenko VI, Zakharov VV, Borodin AV. Rol' translokatsii v patogeneze khirurgicheskoi infektsii [The role of the translocation in the pathogenesis of surgical infection]. Khirurgiia. 2001;(2):63-66.
  48. Bukharin OV, Zak VI, Kurlaev PP, Zykova LS. Usilenie antimikrobnogo deistviia antibiotikov v kombinatsii s oksitotsinom [Increased antimicrobial action of antibiotics in combination with oxytocin]. Antibiotiki. 1984;(5):365-69.
  49. Gavrilenko VG, Esipov VK, Sivozhelezov KG. Morfologicheskaia kharakteristika ranevogo protsessa u bol'nykh s diabeticheskimi gnoino-nekroticheskimi porazheniiami stop pri vozdeistvii oksitotsinom [Morphological characteristics of wound healing process in patients with diabetic pyonecrotic lesions stop when exposed to oxytocin]. Morfologiia. 2003;124(5):24-27.
Address for correspondence:
460000, Russian Federation,
Orenburg, ul. Sovetskaya d. 6,
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e-mail: k_hirurg@orgma.ru,
Petrov Sergey Valentinovich
Information about the authors:
Tretyakov A.A. MD, professor, a head of the surgery chair of "Orenburg State Medical University".
Petrov S.V. PhD, an assistant of the surgery chair of "Orenburg State Medical University".
Neverov A.N. PhD, an associate professor of the surgery chair of "Orenburg State Medical University".
Shchetinin A.F. PhD, an associate professor of the surgery chair of "Orenburg State Medical University".
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