Novosti
Khirurgii

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Year 2015 Vol. 23 No 6

REVIEWS

А.А. GLUKHOV 1, M.V. ARALOVA2

PATHOPHYSIOLOGY OF PERSISTENT CHRONIC WOUNDS AND CURRENT METHODS OF STIMULATION OF WOUND PROCESS

SBEE HPE "Voronezh State Medical University named after N.N. Burdenko",1
BEH "Voronezh regional clinical hospital N1"2,
The Russian Federation

Treatment of persistent chronic wounds completely differented in the etiology, pathogenesis, clinical pictures so far represents one of the most difficult issues of surgery. At the cellular and subcellular levels they are characterized by existence of a chronic inflammation and signs of all 3 phases of wound process simultaneously. In the article the difficult intercellular and cellular matrix interactions, mediators and regulators the reparative processes, participation of separate cellular elements during various temporary periods in normal and pathological healing, the factors modeling wound process are described. The current data of morphology of tissue regeneration obtained by electron microscopy, immunohistochemical researches, an autoradiography allowing the physicians of surgical specialties to provide the effective search of radical and rational methods of treatment of this problem are presented. The wide range of the new directions of tissue and genetic engineering, the cellular therapy used in practical medicine: the preparations of collagen, agents on the basis of negatively charged inert polystyrene microspheres, use of platelet-rich plasma and the preparations containing growth factors, including an endothelium of vessels, techniques of cultivation of fibroblasts, keratinocytes, epidermal cells have been described. The new technologies which are passing still laboratory researches, but having great clinical prospects are specified.

Keywords: persistent chronic wounds, pathogenesis, wound process, trophic ulcers, local treatment, new methods, perspectives
p. 673-679 of the original issue
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Address for correspondence:
396310, Rossiiskaia Federatsiia, g. Voronezh, Moskovskii prospekt, d. 151, "Voronezhskaia oblastnaia klinicheskaia bol'nitsa №1" otdelenie ambulatorno-poliklinicheskoi khirurgii, tel. rab.: 8 803 854 05 43,
e-mail: Mashaaralova@mail.ru,
Aralova Mariia Valer'evna
Information about the authors:
Glukhov A.A., MD, professor, a head of the department of general surgery Medical University "Voronezh State Medical University named after N.N. Burdenko".
Aralova M.V. PhD, a head of the department of outpatient surgery BEH "Voronezh regional clinical hospital N1".
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