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Year 2014 Vol. 22 No 5

GENERAL AND SPECIAL SURGERY

E.V. SHAIDAKOV 1, V.L. BULATOV 1,2, E.I. CHUMASOV1,3, E.S. PETROVA 1, I.N. SONKIN 4, K.P. CHERNIH 5

STRUCTURAL FEATURES OF GREAT SAPHENOUS VARICOSE VEIN IN PATIENTS OF DIFFERENT AGE GROUPS

FSBE “Scientific and Research Institute of Experimental Medicine” North-West Branch of the Russian Academy of Medical Sciences 1,
Saint-Petersburg Institute of Bioregulation and Gerontology 2,
FSBE HPE “Saint-Petersburg State Medical Academy of Veterinary Medicine” 3
NME “Railway Clinical Hospital of JSC "Russian Railways", Saint-Petersburg 4,
Saint-Petersburg SBME “Alexandrov City Hospital5
The Russian Federation

Objectives. To study the features of venous wall varicose transformation in patients of different age groups.
Methods. 32 estuarine fragments of the great saphenous vein (GSV) taken in a crossectomy and stripping of varicose veins have been investigated. Group A included 18 patients aged 60 years or less, group B – 14 patients older than 60. The smooth muscle, elastic elements, vasa vasorom (v.v.), nervi vasorum (n.v.) have been assessed. Statistical analysis has been done on the basis of semi-quantitative data according to the 10-point rating scale using a Spearman’s rank correlation coefficient and Mann-Whitney test.
Result. The marked hypertrophy of the inner circular layer of smooth muscle bundles (SMB) and hypotrophy of the external layer of longitudinal smooth muscle bundles of the median membrane have been found in group B. There is a significant difference between two groups according to the given features these groups (p<0,05). The signs of dystrophy, degeneration, decomposition and fragmentation of elastic fibers in the grains and lumps were considered to be the features of long-existing varicose veins. Some cases of severe degeneration of the internal and external elastic membranes up to its complete destruction have been registered. No statistically significant difference in the density of elastic fibers (p=0,23) war observed between groups. A tendency towards increase the number and diameter of v.v., due to the predominance of varicose venules has been observed in group B. Intergroup difference in density v.v. wear not detected (p=0,19). Degenerative and dystrophic changes of n.v. war revealed in all cases. No statistically significant between-group difference in density of n.v. were detected (p=0,22).
Conclusion. Varicose transformation of the venous wall is a negative progressive process, its dynamics of morphological changes s directly related to the duration of the morbility and age. The most significant signs of varicose transformation are observed in the muscular and connective tissue component of the venous wall.

Keywords: morphology, varicose disease, walls of great saphenous vein, elderly and senile age
p. 560-567 of the original issue
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Address for correspondence:
197376, Rossiiskaia Federatsiia,
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Klinika NII Eksperimental'noi
Meditsiny SZO RAMN,
tel mob: +79218857201,
e-mail: bulatovvas@gmail.com,
Bulatov Vasilii Leonidovich
Information about the authors:
Shaidakov EV, MD, professor, deputy director of the State Organization "Institute of Experimental Medicine" RAMS, Saint-Petersburg.
Bulatov VL, A vascular surgeon FGBI "Institute of Experimental Medicine" RAMS, researcher at the Institute of Bioregulation and Gerontology, Saint- Petersburg.
Chumasov EI, Ph.D., professor of the chair of histology and general biology of FGBU VPO "St. Petersburg State Academy of Veterinary Medicine", a senior researcher at the Department of General and private morphology FGBI "Scientific Research Institute of Experimental Medicine," North West Branch of the Russian Academy of Medical Sciences, Saint-Petersburg.
Petrova ES, PhD, a senior researcher at the Department of general and private morphology. FGBI "Scientific Research Institute of Experimental Medicine," North-West Branch of the Russian Academy of Medical Sciences.
Sonkin IN, MD, a head of the department of vascular surgery. MSH Road Clinical Hospital of JSC "Russian Railways", Saint-Petersburg.
Chernykh KP, a vascular surgeon Petersburg GBUZ "Municipal Alexander Hospital," Saint Petersburg.
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