Novosti
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Year 2012 Vol. 20 No 3
GENERAL AND SPECIAL SURGERY
V.A. KOSINETS
CHANGES IN THE IMMUNE SYSTEM AT GENERALIZED PURULENT PERITONITIS AND POSSIBILITIES OF THEIR CORRECTION
SEE HPE “I.M.Sechenov First Moscow Medical University”,
The Russian Federation
Objectives. To study the state of immune globulin and interleukin profiles of the blood serum in patients with generalized purulent peritonitis and a possibilities of correction of their changes by intracutaneous injections of the preparation «Ronkoleukin».
Methods. The treatment analysis of 26 patients with generalized purulent peritonitis has been conducted. The influence of the intracutaneous injections of the preparation of recombinant interleukin-2 – “Ronkoleukin” on the level of immune globulins and interleukins in the blood serum has been studied.
Results. In patients with generalized purulent peritonitis in the postoperative period the expressed changes in the immune system are observed, characterizing by the disimmunoglobulinemia phenomenon – the decrease in the level of IgM, IgG and the general IgA on the background of the content increase of the secretory IgA in blood serum. From the 1 day of the postoperative period the unidirectional content increase of both the pro-inflammatory (Il-1β, Il-6, Il-8), and anti-inflammatory interleukins (Il-10) has been established on the background of the decrease in the level of regulatory mediators (Il-2, Il-4).
On the background of the conventional treatment the expressed pathological changes from the immune system remained on the 5 day of the postoperative period testifying to the continuing inflammatory process. At the same time in the main group of patients in whom the preparation “Ronkoleukin” was injected intracutaneously as the immune-correcting therapy during the indicated terms the studied parameters were approaching to normal levels or didn’t differ from them.
Conclusions. The obtained data indicate the positive impact of the suggested scheme of immune-corrective therapy on immune globulin and interleukin profiles of the blood in a complex treatment of patients with generalized purulent peritonitis that is possible to regard as a productive immunotropic effect.
Thus, the intracutaneous injections of the preparation “Ronkoleukin” has been firstly proposed while treating generalized purulent peritonitis, which being rather simple in usage permits to reduce significantly the daily volume and duration of the preparation administration.
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119991, Rossiiskaia Federatsiia, g. Moskva, ul. Iauzskaia, d. 11, GOU VPO “Pervyi Moskovskii gosudarstvennyi meditsinskii universitet im. I.M. Sechenova”, kafedra obshchei khirurgii,
e-mail: vkosinets@yandex.ru,
Kosinets Vladimir Aleksandrovich
Kosinets V.A., Candidate of Medical Sciences, Applicant for Doctor’s Degree of the Chair of General Surgery of I.M. Sechenov First Moscow State Medical University.
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