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Year 2009 Vol. 17 No 3

GENERAL AND SPECIAL SURGERY

I.I. KONAKHOVICH, M.M. SACHEK

EXPEDIENCY SUBSTANTIATION OF THE ERADICATION THERAPY USE IN THE TREATMENT OF PATIENTS WITH ACUTE POISONINGS WITH THE SUBSTANCES OF CORRODING ACTION ON THE BASIS OF CLINICAL MODELING

The research is aimed to estimate clinical efficacy of eradication therapy in the patients with acute poisonings with the substances of corroding action on the basis of “decision tree”. 116 patients with acute poisonings with the substances of corroding action composed the research group. H. pylori diagnostics was made by means of the urease test and histological study. “Decision tree” was modeled; the risk of development of the H. рylori dissemination distant consequences in the stomach mucous membrane was estimated. Eradication application in the patients with acute poisonings with the substances of corroding action contributes to the additional increase of the therapy efficacy: stomach ulcer prevention during 1-year period in 21% of patients and during 2-year period – in 25%; stomach hemorrhage prevention – in 4,7%; stomach cancer prevention – in 2,4% of patients. Eradication application in case of the stomach chemical burns caused by the substances of corroding action in Helicobacter pylori positive patients improves the prognosis: it prevents stomach ulcers development during 1-year period in 30% and during 2-year period in 34% of patients, stomach hemorrhage development – in 3,5%, stomach cancer – in 1% of patients.

Keywords: acute poisonings with the substances of corroding action, Helicobacter pylori, risk of the stomach ulcer, hemorrhage, stomach cancer development
p. 42 - 57 of the original issue
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