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Khirurgii

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Year 2017 Vol. 25 No 2

GENERAL & SPECIAL SURGERY

O.S. OLIFIROVA, A.A. KOZKA

VALUE OF ANTIOXIDANTS AND HYPERBARIC OXYGENATION IN TREATMENT OF BURN WOUNDS

FSBEE HE "Amur State Medical Academy" of Ministry of Health of the Russian Federation,
Blagoveshchensk,
The Russian Federation

Objectives. To assess the value of antioxidants and hyperbaric oxygenation in the complex treatment of burn wounds.
Methods. The treatment analysis of 54 patients with I-II-III degree burns (ICD-10) of different localization has been carried out. In the complex treatment of the main group (n=28), the oral administration of antioxidants (the mixture of dihydroquercetin and arabinogalactan, 1:3) 1 capsule twice a day for 21 days was indicated as well as local application of the powder of dihydroquercetin. At the same time in case of I-II degree burns – 8-10 sessions of hyperbaric oxygenation of 1,5 to 1,8 atmospheres in the chamber "OKA-M", 40 minutes daily were carried out. In case of III degree burns – hyperbaric oxygen was carried out up to delayed autodermoplasty with a free split skin graft and starting from the first postoperative day with in 7 days. The clinical comparison group was comprised of patients (n=26) who received the traditional treatment.
Results. In patients of the main group who received antioxidant therapy and hyperbaric oxygenation the course of wound healing is characterized by even process, manifested in reduction of pain syndrome and the temperature reaction, in the early appearance of granulation, marginal and complete epithelialization of wounds of I-II degree burns was noted, as well as the reduction of preoperative preparation terms of III degree burns. Due to the stimulation of reparative processes, complete engraftment of the split free autodermotransplant was achieved in 100% of cases in the main group and only in 72,4% – in the clinical group. Hyperproduction of pro-inflammatory interleukins (IL-1β, IL-6, IL-8, TNF-α) was observed in all patients, however, to the 21st day of treatment, its significant reduction was registered in the main group. Antioxidants and hyperbaric oxygen application permitted to reduce the intensity of lipid peroxidation and to increase the activity of antioxidant protection system.
Conclusion. The conducted study showed the efficacy of application of antioxidants and hyperbaric oxygen therapy in complex treatment of patients with burn wounds.

Keywords: burn wounds, dihydroquercetin, arabinogalactan, hyperbaric oxygenation, engraftment, lipid peroxidation, pro-inflammatory cytokines
p. 148-154 of the original issue
References
  1. Gerasimova LI. Termicheskie porazheniia. V kn: Gerasimova LI, Nazarenko GI, red. Termicheskie i radiatsionnye ozhogi: ruk dlia vrachei [Thermal lesion]. Moscow, RF; 2005. p. 38-195.
  2. Herdon DN. Total burn care. 4th ed. Edinburgh: Saunders Elsevier; 2012. 808 p.
  3. Alekseev AA, Tiurnikov IuI. Statisticheskie pokazateli raboty ozhogovykh statsionarov Rossiiskoi Federatsii za 2009 god [Statistical indicators of burn hospitals of the Russian Federation in 2009]. Kombustiologiia. [Elektronnyi resurs]. 2011;(44). [Data dostupa: 06.06.2016]. Rezhim dostupa: http://combustiolog.ru/journal/statisticheskie-pokazateli-raboty-ozhogovy-h-statsionarov-rossijskoj-federatsii-za-2009-god
  4. Ryssel H, Germann G, Kloeters O, Gazyakan E, Radu CA. Dermal substitution with Matriderm(®) in burns on the dorsum of the hand. Burns. 2010 Dec;36(8):1248-53. doi: 10.1016/j.burns.2010.05.003.
  5. Opasanon S, Muangman P, Namviriyachote N. Clinical effectiveness of alginate silver dressing in outpatient management of partial-thickness burns. Int Wound J. 2010 Dec;7(6):467-71. doi: 10.1111/j.1742-481X.2010.00718.x.
  6. Pleshkov A.S., Shapovalov S.G., Panov A.V. Khirurgicheskoe lechenie postradavshikh ot ozhogov (obzor literatury) [Surgical treatment of burn victims (literature review)]. Kombustiologiia. [Elektronnyi resurs]. 2015;(54). [Data dostupa: 06.06.2016]. Rezhim dostupa: http://combustiolog.ru/journal/hirurgicheskoe-lechenie-postradavshih-ot-ozhogov-obzor-literatury-2.
  7. Namokonov EV, Lazutkin MN, Miromanov LM. Antioksidantnaia stimuliatsiia reparativnykh protsessov v rane v eksperimente [Antioxidant stimulation of reparative processes in the wound in the experiment]. Biul VSNTs SO RAMP. 2012;(4 ch 1):215-17.
  8. Kozka AA, Olifirova OS. Antioksidanty i giperbaricheskaia oksigenatsiia v kompleksnom lechenii bol'nykh s glubokimi ozhogami [Antioxidants and hyperbaric oxygen therapy in the complex treatment of patients with deep burns]. Prakt Meditsina. 2015;(6):112-15.
  9. Bagaev VG, Sergeeva VV, Bobrova AA, Medinskii PV, Nalbandian RT, Davydov MIu, i dr. Giperbaricheskaia oksigenatsiia v kompleksnoi terapii ran u detei [Hyperbaric oxygen therapy in the treatment of wounds in children]. Rany i Ranevye Infektsii. 2014;(2): 31-37.
  10. Premiksy Lavitol-V [Premixes Lavitol-V] [Elektronnyi resurs]. [Data dostupa: 06.06.2016]. Rezhim dostupa: https://www.ametis.ru/production/premixes.
  11. Lavitol kosmeticheskii [Cosmetic Lavitol] [Elektronnyi resurs]. [Data dostupa: 06.06.2016]. Rezhim dostupa: https://www.ametis.ru/production/lavitol-cosmetics.
  12. Olifirova OS, Tseluiko SS, Bregadze AA, Lebed' AA, Alekseevnina VV, Shtarberg MI. Sposob stimuliatsii zazhivleniia ran razlichnogo geneza prirodnym antioksidantom digidrokvertsetinom [A method of stimulating of wound healing of various genesis by natural antioxidant dihydroquercetin]. Patent Ros Federatsii N 2522214. 15.05.2014.
  13. Baidin SA, Gramenitskii AB, Rubinchik BA, red. Rukovodstvo po giperbaricheskoi meditsine [Guidelines for hyperbaric medicine]. Moscow, RF: Meditsina; 2008. 560 p.
  14. Olifirova OS, Bregadze AA, Kozka AA, Kiridon OI. Sposob stimuliatsii zazhivleniia dermal'nykh ozhogov [A method of stimulating the healing of dermal burns]. Patent Ros Federatsii N2577950. 20.03.2016.
Address for correspondence:
675000, Russian Federation,
Blagoveshchensk, Gorky str., 95,
FGBOU «Amur State Medical Academy»
Faculty of Postgraduate Education,
Department of surgical diseases.
Tel.: 7 914 554-46-52
e-mail: olif.oc@mail.ru
Olga S.Olifirova
Information about the authors:
Olifirova O.S. MD, Ass. Professor, Head, department of surgical diseases, FSBEE HE "Amur State Medical Academy" of Ministry of Health, the Russian Federation, Blagoveshchensk.
Kozka A.A. Post-graduate student of department of surgical diseases, FSBEE HE "Amur State Medical Academy" of Ministry of Health, the Russian Federation, Blagoveshchensk.
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