Novosti
|
This journal is indexed in Scopus |
|---|
Year 2012 Vol. 20 No 2
GENERAL AND SPECIAL SURGERY
V.A. KLOPOVA, I.V. SAMSONOVA, A.T. SHCHASTNY, M.I. KUGAEV
CHARACTER OF NEUROFILAMENT EXPRESSION IN THE PANCREAS AT CHRONIC PANCREATITIS
EE “Vitebsk State Medical University”,
The Republic of Belarus
Objectives. To study NF (neurofilament) expression in the pancreas tissue at chronic pancreatitis as well as the correlation of its expression degree and fibrous changes expression.
Methods. Using morphological, immunohistochemical, morphometric and statistical methods we investigated pancreas of 43 patients with chronic pancreatitis in whom duodenum-saving resection of its head had been done.
Results. Morphometric assessment revealed fibrous changes variation from 10 to 98% in pancreas at chronic pancreatitis. Degree of NF expression varied from 0 to 251 points and didn’t depend on the fibrous changes expression (p>0,05). Percentage of positive expressed nerve elements varied from 0 to 100, signing the decrease of mature and viable elements in pancreas specimens with more severe fibrous changes.
Conclusions. It was found out that in the pancreas at chronic pancreatitis marked fibrous changes were developing together with the diffused degenerative changes of parenchyma and the nervous tissue was involved with it total area increase. The area of mature and viable nerve tissue was decreased
1. Gustomvsova VI. Primenenie biorezonansnoi terapii v kompleksnom lechenii bol'nykh khronicheskim pankreatitom [The use of bio-resonance therapy in treatment of patients with chronic pancreatitis]. Elektron resurs. 2009. Rezhim dostupa: http://www.biorezonans.by. Data dostupa: 07.11.2010.
2. Spanier BWM, Dijkgraaf MG, Bruno MJ. Epidemiology, aetiology and outcome of acute and chronic pancreatitis. Best Pract Res Clin Gastroenterol. 2008;22(1):45–63.
3. Maev IV. Khronicheskii pankreatit: ucheb posobie [Chronic pancreatitis: a study guide]. Moscow, RF: VUMNTs; 2003. 68 p.
4. Otsuki M. Chronic pancreatitis in Japan: epidemiology, prognosis, diagnostic criteria, and future problems. J Gastroenterol. 2003;38:315–26.
5. Tret'iak SI, Rashchinskii SM, Rashchinskaia TR, Avdevich DA. Epidemiologiia i etiologiia khronicheskogo pankreatita [Epidemiology and etiology of chronic pancreatitis]. Zdravookhranenie. 2010;(1):15–19.
6. Lowenfels AB, Maisonneuve P, Cavallini G, Ammann RW, Lankisch PG, Andersen JR, DiMagno EP, Andren-Sandberg A, Domellof L, Di Francesco V, et al. Prognosis of chronic pancreatitis: an international multicenter study. International Pancreatitis Study Group. Am J Gastroenterol. 1994 Sep;89(9):1467–71.
7. Talamini G, Falconi M, Bassi C, Mastromauro M, Salvia R, Pederzoli P. Chronic Pancreatitis: Relationship to Acute Pancreatitis and Pancreatic Cancer. Journal of the Pancreas. 2000 Sep;1(3 Suppl.):69–76.
8. Gubergrits NB. Khronicheskaia abdominal'naia bol'. Pankreaticheskaia bol': kak pomoch' bol'nomu. [Chronic abdominal pain. Pancreatic pain: how to help the patient]. Moscow, RF: Medpraktika; 2005. 176 p.
9. Buscher HC, Jansen JB, van Dongen R, Bleichrodt RP, van Goor H. Long-term results of bilateral thoracoscopic splanch- nicectomy in patients with chronic pancreatitis. Br J Surg. 2002 Feb;89(2):158–62.
10. Matsumura N, Ochi K, Ichimura M, Mizushima T, Harada H, Harada M. Study on free radicals and pancreatic fibrosis–pancreatic fibrosis induced by repeated injections of superoxide dismutase inhibitor. Pancreas. 2001 Jan;22(1):53–7.
11. Bockman DE, Buchler M, Malfertheiner P, Beger HG. Analysis of nerves in chronic pancreatitis. Gastroenterology. 1988 Jun;94(6):1459–69.
12. Fink T, Di Sebastiano P, Buchler M, Beger HG, Weihe E. Growth-associated protein-43 and protein gene-product 9.5 innervation in human pancreas: changes in chronic pancreatitis. Neuroscience. 1994 Nov;63(1):249–66.
13. Buchler M, Weihe E, Friess H, Malfertheiner P, Bockman E, Muller S, Nohr D, Beger HG. Changes in peptidergic innervation in chronic pancreatitis. Pancreas. 1992;7(2):183–92.
14. Di Sebastiano P, di Mola FF, Di Febbo C, Baccante G, Porreca E, Innocenti P, Friess H, Buchler MW. Expression of interleukin 8 (IL-8) and substance P in human chronic pancreatitis. Gut. 2000 Sep;47(3):423–28.
15. Shrikhande SV, Friess H, di Mola FF, Tempia-Caliera A, Conejo Garcia JR, Zhu Z, Zimmermann A, Buchler MW. NK-1 receptor gene expression is related to pain in chronic pancreatitis. Pain. 2001 Apr;91(3):209–17.
16. Toma H, Winston J, Micci MA, Shenoy M, Pasricha PJ. Nerve growth factor expression is up-regulated in the rat model of L-arginine-induced acute pancreatitis. Gastroenterology. 2000 Nov;119(5):1373–81.
17. Friess H, Zhu ZW, di Mola FF, Kulli C, Graber HU, Andren-Sandberg A, Zimmermann A, Korc M, Reinshagen M, Buchler MW. Nerve growth factor and its high affinity receptor in chronic pancreatitis. Ann Surg. 1999 Nov;230(5):615–24.
210023, Respublika Belarus', g. Vitebsk, pr. Frunze, d. 27, UO “Vitebskii gosudarstvennyi meditsinskii universitet”, kafedra patologicheskoi anatomii,
e-mail: victoriya_06@tut.by,
Klopova Viktoriia Aleksandrovna
Klopova V.A., a post-graduate student of the pathologic anatomy chair of EE "Vitebsk State Medical University."
Samsonova I.V., candidate of medical sciences, associate professor, a head of the pathological anatomy chair of EE "Vitebsk State Medical University."
Shchastny A.T., candidate of medical sciences, associate professor of the surgery chair of the faculty of advanced training and retraining of specialists of EE “Vitebsk State Medical University”.
Kugaev M.I., an assistant of the chair of general surgery of EE “Vitebsk State Medical University”.
Article in the .pdf format
