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Year 2019 Vol. 27 No 1

REVIEWS

А.V. OREHVA 1, 2, Е.А. SHLIAKHTUNOU 1, V.М. SEMENOV 1

CLINICAL SIGNIFICANCE OF INHIBITOR OF APOPTOSIS PROTEIN SURVIVIN EXPRESSION IN COLORECTAL CANCER

Vitebsk State Medical University 1
Vitebsk Regional Clinical Oncology Center 2, Vitebsk,
The Republic of Belarus

All over the world, colorectal cancer occupies the third place in terms of incidence and is the leading cause of death from malignant neoplasms. The incidence of colon cancer is expected to have 60 % increased by 2030 and will make up 2.2 million new cases per year. But despite modern diagnostics, the disease is mainly detected in the 3-4 stages. Even with the treatment of early tumor forms, progression occurs in 40-50% of patients. Tumor markers are used to monitor the development of the tumor process, but not all of them are highly sensitive and specific. In recent years, there has been an active search for new diagnostic markers that could not only predict the development of the disease but would also be the markers of a response to chemo-radiotherapy. The expression of inhibitor of apoptosis proteins (IAP) is known to increase the viability of tumor cells, and their overexpression leads to chemo-radio-resistance and is always associated with poor clinical prognosis of the disease. Due to this, inhibitor of apoptosis proteins are considered as a promising target in gene therapy for cancer. One of the most studied members of the IAP protein family is the survivin protein. In this literature review, the issue of clinical use of inhibitor of apoptosis protein survivin in colorectal cancer will be considered.

Keywords: colorectal cancer, rectal cancer, survivin, inhibitor of apoptosis proteins, prognostic tumor marker
p. 72-80 of the original issue
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Address for correspondence:
210023, The Republic of Belarus,
Vitebsk, Frunze Ave., 27,
Vitebsk State Medical University,
Department of Oncology with
The Courses of Radiology, Radiation Therapy,
Faculty of Training and Retraining
Of the Medical Specialists.
Tel.: +375-33-900-44-00,
e-mail: dr.orehva@yandex.ru,
Andrey V. Orehva
Information about the authors:
Orehva Andrey V., Surgeon-Oncologist of the Oncological Abdominal Unit, Vitebsk Regional Clinical Oncology Center, Applicant of the Department of Oncology with the Courses of Radiology, Radiation Therapy, the Faculty of Training and Retraining of the Medical Specialists, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0001-9145-4216
Shliakhtunou Yauheni A., Associate Professor of the Department of Oncology with the Courses of Radiology, Radiation Therapy, the Faculty of Training and Retraining of the Medical Specialists, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0002-5906-5373
Semenov Valeri M., MD, Professor, Head of the Infectious Diseases Department, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0002-7029-9226
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