Novosti
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This journal is indexed in Scopus |
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Year 2012 Vol. 20 No 1
EXPERIMENTAL SURGERY
I.O. POKHODENKO-CHUDAKOVA 1, E.V. MAKSIMICH 1, S.F. KURALENYA 2
COMPARATIVE EVALUATION OF MORPHOLOGICAL CHANGES AT DIFFERENT VARIANTS OF INJECTION OF 2% SOLUTION OF LYDOKAIN HYDROCHLORIDE IN EXPERIMENT
EE “Belarusian State Medical University” 1,
ME “Minsk consultational -diagnostics center” 2,
the Republic of Belarus
Objectives. To study the morphological changes of the parenchymatous organs of the laboratory animals at various variants of the local anesthetic 2% lidocaine hydrochloride solution in the experiment at its frequent repeated injections.
Methods. The research was carried out on 27 white mouse males. All animals were divided into two series (16 and 11 animals) in which the anesthetic was injected 5 times a day in every 3-4 days (in the dose 50 mg/kg of the animal weight). Anesthetic injection was made in the maxillofacial area in the animals of the first series (the variant of the conducting mandibular anesthesia outside the mouth); intraperitoneal introduction of the drugs was made in the second series animals.
Results. Lethality after 2% lidocaine hydrochloride solution injection made up 37,5%. There were no lethal outcomes in the second series. Significant incidence of toxic manifestation from the central nervous system was established in the experimental animals of the first series; it can be explained by peculiarity of the head and neck vascularization and innervation. The most evident morphological changes of the parenchymatous organs were noted in the animals of the first series.
Conclusions. Morphological changes of the parenchymatous organs of the laboratory animals depend on the region of 2% lidocaine hydrochloride solution injection; it should be taken into consideration when conducting preclinical studies of drugs, used in the dental practice.
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220116, Respublika Belarus', g. Minsk, pr-t. Dzerzhinskogo, d. 83, UO “Belorusskii gosudarstvennyi meditsinskii universitet”, kafedra khirurgicheskoi stomatologii,
e-mail: ip-c@yandex.ru,
Pokhodenko-Chudakova Irina Olegovna
Pokhodenko-Chudakova I.O. Doctor of medical sciences, professor, head of the surgical dentistry chair of EE “Belarusian State Medical University”.
Maksimovich E.V. Assistant of the surgical dentistry chair of EE “Belarusian State Medical University”.
Kuralenya S.F. head of the laboratory of clinical pathologic histology of ME “Minsk Consultational -Diagnostics Center”.
