Novosti
Khirurgii

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Year 2019 Vol. 27 No 1

SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY

O.YA. POPADYUK 1, O.S. MALYSHEVSKA 1, L.YA. ROPYAK 2, V.S. VYTVYTSKYI 2, M.М. DRONIAK 1

STUDY OF NANO-CONTAINING BIOPOLYMER FILMS THERAPEUTIC AND PHYSICAL-MECHANICAL PROPERTIES

Ivano-Frankivsk National Medical University1,
Ivano-Frankivsk National Technical University of Oil and Gas2,
Ivano-Frankivsk,
Ukraine

Objective. To investigate the influence of component composition and technological parameters of the formation of nano-containing biopolymer films on their therapeutic and physico-mechanical properties.
Methods. The authors studied nano-containing biopolymer films for wound treatment, which had contained gelatin, polyvinyl alcohol, glycerol, lactic acid, distilled water and zinc nano oxide with various technological mode manufactured. The studied options were as follows: elasticity, degradation time, vapor permeability of biopolymer films. Therapeutic properties of biopolymer films were evaluated based on the results of measuring the protective action diameter.
Results. The biopolymer film treatment properties are directly related to the diameter of the protective action. It has been defined that protective effect diameter of films containing zinc nanooxide increases both with an increase in the ratio of the concentrations of the components of the mixture and with an increase in the content of zinc nanooxide, reaching a maximum protective action diameter of 20.5 mm with its content of 197 mg.
Thermostat exposition period increasing leads to protective action diameter decreasing reaching a minimum, and in the future slightly increases. The increase in the heating temperature adversely affects the therapeutic properties of the film, which is due to the compaction of its structure. The film degradation time increases with increase of component concentration ratio, the zinc nanooxide concentration and the mixture heating temperature. Component composition and biopolymer film obtaining regimes and their influence on elasticity, degradation time and vapor permeability were studied. Introduction of zinc nanooxide into the composition of the film increases firstly its vapor permeability, which, after reaching the maximum, decreases. Biopolymer film is environmentally safe, water and carbon dioxide are released in its destruction. Nano-oxide of zinc is a weakly toxic, non-aggressive component, present in the products of destruction of the film in the bound state and insignificant amount.
Conclusions. Carried out studies have shown that the treatment properties of biodegradable polymeric materials depend on zinc nanooxide concentration, and their degradation properties provide metered delivery of the medicament to the lesion area.

Keywords: wound treatment, nano-containing biopolymer films, therapeutic effect, physical and mechanical properties, environmentally safe polymers, biopolymer utilization
p. 16-25 of the original issue
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Address for correspondence:
76018, Ukraine,
Ivano-Frankivsk, Galickaya Str., 2,
Ivano-Frankivsk National Medical University,
Department of General Surgery.
Tel.: +380 34 252-82-32,
e-mail: popadyukoleg@ukr.net,
Oleg Y. Popadyuk
Information about the authors:
Popadyuk Oleg Y., PhD., Associate Professor, Associate Professor of the Department of General Surgery, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine.
http://orcid.org/0000-0001-6287-1280
Malyshevska Olga S., PhD., Associate Professor of the Department of Hygiene and Ecology, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine.
http://orcid.org/0000-0003-0180-2112
Ropyak Lubomyr Y., PhD., Associate Professor, Associate Professor of the Department of Computer Engineering, Ivano-Frankivsk National Technical University of Oil and Gas, Ivano-Frankivsk, Ukraine.
http://orcid.org/0000-0002-9374-2550
Vytvytskyi Vasyl S., Postgraduate Student of the Department of Machine Mechanics, Ivano-Frankivsk National Technical University of Oil and Gas, Ivano-Frankivsk, Ukraine.
http://orcid.org/0000-0003-3682-1612
Droniak Mykola M., PhD, Associate Professor, Associate Professor of the Department of Surgery and Cardiac Surgery, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine.
http://orcid.org/0000-0001-7976-0384
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