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Year 2008 Vol. 16 No 1

ONCOLOGY

GIDRANOVICH A.V.

METABOLIC ACTIVITY OF GLYCOLYSIS IN THE BLOOD SERUM OF BREAST CANCER PATIENTS

We studied the activity of glucosephosphate isomerase, fructose-1, 6-bisphosphate aldolase and lactate dehydrogenase in serum of breast cancer patients and healthy female donors at the age of 40–55. The rise of activity of glucosephosphate isomerase was observed in breast cancer patients in comparison with healthy donors. The highest activity of glucosephosphate isomerase was observed in patients with the 4th stage of breast cancer. Activity of fructose-1, 6-bisphosphate aldolase had the tendency to rise in the patients with operable breast cancer of the 1st – 3rd stages. Activity of lactate dehydrogenase was higher in breast cancer patients when compared with healthy donors. The decrease of ratio of lactate dehydrogenase to glucosephosphate isomerase may be due to increased expression of glucosephosphate isomerase in malignant cells that may testify to aggressive tumor phenotype.

Keywords: breast cancer, glycolysis, glucosephosphate isomerase, fructose-1, 6-bisphosphate aldolase, lactate dehydrogenase.
p. 88 – 95 of the original issue
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