Year 2022 Vol. 30 No 4

REVIEWS

M.N. MURAVYOV, V.A. PANFILOV, K.V. ROMANENKO, A.O. VIRGANSKY

ASPECTS OF ANTICOAGULANT AND ANTIPLATELET THERAPY IN PATIENTS WHO UNDERWENT PERIPHERAL ARTERY RECONSTRUCTION. HISTORY AND THE PRESENT

Pirogov Russian National Research Medical University, Moscow,
Russian Federation

The use of anticoagulants and disaggregant agents in patients with peripheral atherosclerosis has been an integral part of therapy for many years. . The role and their combination has undergone numerous changes with the development of understanding of their mechanisms of action and influence on peripheral hemodynamics. In addition, the use of anticoagulants and disaggregant agents plays a decisive role in patients with critical lower limb ischemia who underwent reconstruction of the peripheral arterial bed. In the postoperative period in many cases the precisely well-chosen tablet therapy can be the very key link in saving the limb. Besides, atherosclerosis is multi-organ disease that usually affects the coronary and cerebral pools. Pathological processes in these systems can significantly affect the health and quality of life, are often disabling nature, often threatening the patients life. Today the inconsistency of clinical and practical information about the effectiveness of various schemes of antiplatelet and anticoagulant therapy is beyond doubt. For example, the required duration of tablet therapy is not supported by reliable studies. A large number of outdated studies, their insufficient scale are consided to be a stumbling block for determining the current unified standard of perioperative therapy for patients with peripheral atherosclerosis. The identification of the ideal scheme will allow improving the immediate and remote results of surgical interventions, but also to carry out an effective prevention of formidable complications of the cardiovascular system as a whole.

Keywords: peripheral artery atherosclerosis, low limb ischemia, femoropopliteal bypass, low limb amputation, anticoagulants, disaggregants
p. 382-391 of the original issue
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Address for correspondence:
117997, Russian Federation,
Moscow, st. Ostrovityanov, house 1,
Russian National Research
Medical University N.I. Pirogov,
Department of Faculty Surgery No. 1
of the Faculty of Medicine,
tel: +7 916 824-07-31,
e-mail: muravyov.mn@gmail.com,
Muravyov Maxim N.
Information about the authors:
Virgansky Anatoly O., MD, Professor of the Department of Faculty Surgery No. 1 of the Medical Faculty of the Russian National Research Medical University Named after N.I. Pirogov, Moscow, Russian Federation.
https://orcid.org/0000-0002-0204-7991
Muravyov Maksim N., Post-Graduate Student of the Department of Faculty Surgery No. 1 of the Medical Faculty of the Russian National Research Medical University Named after N.I. Pirogov, Moscow, Russian Federation.
http://orcid.org/0000-0001-9742-4333
Panfilov Vladislav A., Cardiovascular Surgeon, CSH im. V.V. Vinogradova, Moscow, Russian Federation.
http://orcid.org/0000-0001-5186-5459
Romanenko Konstantin V., Cardiovascular Surgeon, Head of the Department of Vascular Surgery, CCH Named after V.V. Vinogradova, Moscow, Russian Federation.
http://orcid.org/0000-0002-0342-746X
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