Novosti
Khirurgii

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Year 2022 Vol. 30 No 4

SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY

V.A. DUDKO 1, 2, T.I. KLEPCHA 1, A.L LIPNITSKI 1, 2, A.V. MAROCHKOV 1, 2, T.V. SERGIEVICH 1

DYNAMICS OF CORTISOL LEVEL DURING ANESTHESIA OF CARDIOSURGERY UNDER CARDIOPULMONARY BYPASS

Mogilev Regional Clinical Hospital 1, Mogilev,
Vitebsk State Order of Peoples’ Friendship Medical University 2, Mogilev, Republic of Belarus

Objective. The aim of our research was to define the dynamic of the cortisol level in patients in the perioperative period during cardiac surgery.
Methods. A prospective nonrandomized observational study was carried out, which included 30 cardiac surgery patients. The age of the patients ranged from 49 to 67 years (64.0 (59.56; 33.25) years), body mass index – 29.05 (25.56; 33.25) kg/m². All patients underwent cardiac surgery under cardiopulmonary bypass. All patients underwent blood sampling at the following stages: stage 1 – the patient was on an operation table, catheterization of the peripheral vein, intravenous blood sampling; stage 2 – the patient is on the operating table, before being connected to the cardiopulmonary bypass; stage 3 – the end of the operation, suturing skin; stage 4 – the patient is in the intensive care unit, 1-3 hours after the operation; stage 5 – 17-20 hours later after the operative intervention. The quantitative determination of cortisol in the blood serum was carried out by the immunochemical method using the apparatus Architect plus i10000sr (Abbott, USA).
Results. In stage 1, the cortisol level was 8.5 (6.3; 10.4) mcg/dl; at stage 2 – 11.0 (5.1; 14.3) mcg/dl; when suturing the skin – 28.4 (16.6; 36.5) mcg/dl; after 1-3 hours after the operation – 18.55 (14.6; 23.5) mcg/dl; on the next day – 13.2 (8.0; 19.9) mcg/dl. We also revealed a reliable difference in the level of cortisol in the serum at stages 3 and 5, depending almost on the inclusion of prednisolone in the composition of the primary solution.
Conclusion. Determination of the level of cortisol should be used as a component of anesthetic monitoring during cardiac surgery.

Keywords: cardiac surgery, anesthesia, cortisol, cardiopulmonary bypass, prednisolone
p. 358-365 of the original issue
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Address for correspondence:
212016, Republic of Belarus,
Mogilev, st. Belynitsk-Biruli, 12,
Mogilev Regional Clinical Hospital,
Department of Anesthesiology and Resuscitation
of the Center for Cardiovascular Surgery,
tel.: +375 222 62-75-95,
e-mail: vladimirdudko@mail.ru,
Dudko Vladimir A.
Information about the authors:
Dudko Vladimir A., Anesthesiologist, Head of the Department of Anesthesiology and Intensive Care of the Ñenter of Cardiovascular Surgery, Mogilev Regional Clinical Hospital, the Branch of the Departments of Anesthesiology and Resuscitation with a course of the Faculty of the Advanced Training and Retraining and Surgery of the Faculty of the Advanced Training and Retraining of Vitebsk State Medical University, assistant, Mogilev, Republic of Belarus.
https://orcid.org/0000-0002-5959-5454
Klepcha Tatyana I., Anesthesiologist, Department of Anesthesiology and Intensive Care of the Ñenter of Cardiovascular Surgery, Mogilev Regional Clinical Hospital, Mogilev, Republic of Belarus.
https://orcid.org/0000-0002-4426-0213
Lipnitski Artur L., PhD, Anesthesiologist, Head of the Department Coordination for Organ and Tissue Transplantation Mogilev Regional Clinical Hospital, the Branch of the Departments of Anesthesiology and Resuscitation with a Course of the Faculty of the Advanced Training and Retraining and Surgery of the Faculty of the Advanced Training and Retraining of Vitebsk State Medical University, Mogilev, Republic of Belarus.
https://orcid.org/0000-0002-2556-4801
Marochkov Alexey V., MD, Professor, Anesthesiologist of Anesthesiology and Intensive Care Unit, Mogilev Regional Clinical Hospital, the Branch of the Departments of Anesthesiology and Resuscitation with a Course of the Faculty of the Advanced Training and Retraining and Surgery of the Faculty of the Advanced Training and Retraining of Vitebsk State Medical University, Professor, Mogilev, Republic of Belarus.
https://orcid.org/0000-0001-5092-8315
Sergievich Tatyana V., Physician of Clinical Laboratory Diagnostics, Head of the Department of Clinical Laboratory Diagnostics, Mogilev Regional Clinical Hospital, Mogilev, Republic of Belarus.
https://orcid.org/0000-0003-4981-5430
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