Year 2022 Vol. 30 No 2

GENERAL & SPECIAL SURGERY

A.YU. NISHT, N.F. FOMIN

ANATOMICAL AND EXPERIMENTAL APPROACHES TO SUBSTANTIATION OF THE TECHNIQUES OF ACCELERATED SELECTIVE REINNERVATION OF THE THENAR MUSCLES IN PROXIMAL INJURIES OF PERIPHERAL NERVES

S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg,
Russian Federation

Objective. To provide a topographical and anatomical justification of techniques of accelerated selective reinnervation of the thenar muscles with high proximal trauma and extensive defects of the median nerve.
Methods. Structural features and topography of the muscular branches of peripheral nerves were studied on 37 upper limbs of cadavers. Modeling of the stages of reconstructive interventions with the connection of nerves according to the technique «end-to-side» was performed on 15 upper limbs in experiment.
Results. Individual differences in the structure of peripheral nerves mainly consist of the unequal quantity and size of bundles of nerve fibers, as well as the severity of intratrunk interfascicular connections and depend on the shape of the limb segments. The ulnar and the median nerves, a potential pair of «donor-recipient» nerves, are located reliably closer to each other on the relatively narrow and long limbs, compared to the wide and short ones. Based on the anatomical material the operative access was developed and tested to create optimal technical conditions for performing early selective reinnervation of the muscles of the first finger elevation in case of high proximal injuries and extensive defects of the median nerve. The essence of the proposed surgical intervention is to mobilize the recurrent motor branch of the median nerve and connect it «end-to-side» with the deep branch of the ulnar nerve.
Conclusion. Performing intra-trunk microsurgical operations on nerves with the formation of "end - to-side" perineural anastomoses allows creating morphological conditions for a directed regeneration of nerve fibers from the deep branch of the ulnar nerve to the tissues of the target zones of the recurrent motor branch of the median nerve.More extended nerve branches with a small number of interfascicular connections, characteristic of relatively narrow and long limbs, contribute to the creation of conditions for less traumatic mobilization and transposition of motor branches with aim to selectively reinnervate tissues with an «end-to-side» peripheral nerve suture.

Keywords: peripheral nerve, nerve injury, «end-to-side» neurorrhaphy, motor innervation, tenar muscles, restoration of thumb opposition
p. 179-185 of the original issue
References
  1. Konofaos P, Bassilios Habre S, Wallace RD. End-to-Side Nerve Repair: Current Concepts and Future Perspectives. Ann Plast Surg. 2018 Dec;81(6):736-40. doi: 10.1097/SAP.0000000000001663
  2. Tuffaha SH, Meaike JD, Moran SL. Direct muscle neurotization with long acellular nerve allograft: A case report. Microsurgery. 2020 Feb;40(2):258-60. doi: 10.1002/micr.30498
  3. Batzalenko N, Reshetov IV, Kharkova NV. Direct muscle neurologization: mechanism, methods of axonal growth stimulation. evaluation of the results. Golova i Sheia= Head and Neck. Russian Journal. 2017;(4):53-56. https://headneckfdr.ru/files/HM2017004.pdf (In Russ.)
  4. Zhuravlev SA, Golubev IO. Variants of neurotization in injuries of brachial plexus and nerves of upper extremity. Vestnik Travmatologii i Ortopedii im NN Priorova. 2015;22(4):77-82. doi: 10.17816/vto201522477-82 (In Russ.)
  5. Millesi H, Schmidhammer R. Nerve fiber transfer by end-to-side coaptation. Hand Clin. 2008 Nov;24(4):461-83, vii. doi: 10.1016/j.hcl.2008.04.007
  6. Beris A, Gkiatas I, Gelalis I, Papadopoulos D, Kostas-Agnantis I. Current concepts in peripheral nerve surgery. Eur J Orthop Surg Traumatol. 2019 Feb;29(2):263-269. doi: 10.1007/s00590-018-2344-2
  7. Geuna S, Papalia I, Ronchi G, d'Alcontres FS, Natsis K, Papadopulos NA, Colonna MR. The reasons for end-to-side coaptation: how does lateral axon sprouting work? Neural Regen Res. 2017 Apr;12(4):529-33. doi: 10.4103/1673-5374.205081
  8. Paiva GR, Viterbo F, Deffune E, Custódio MAD. Stem cells in end-to-side neurorrhaphy. Experimental study in rats. Acta Cir Bras. 2021 Jan 20;35(12):e351207. doi: 10.1590/ACB351207. eCollection 2021.
  9. Nisht AY, Fomin NF, Imelbaev AI, Mikulich AA. Restoration of motor innervation by the «end-to-side» neurorraphia: experimental modeling and clinical and instrumental control of reinnervation. Journal of Experimental and Clinical Surgery. 2020;13(1):24-33. doi: 10.18499/2070-478X-2020-13-1-24-33 (In Russ.)
  10. Ozcelik IB, Yildiran G, Mersa B, Sutcu M, Celik ZE, Ozalp T. A novel nerve transfer: The first palmar interosseous motor branch of the ulnar nerve to the recurrent motor branch of the median nerve. Injury. 2020 Dec;51 Suppl 4:S81-S83. doi: 10.1016/j.injury.2020.02.119
  11. Aman M, Böcker A, Kneser U, Harhaus L. Selective nerve transfers for thenar branch reconstruction. Oper Orthop Traumatol. 2021 Oct;33(5):384-91. doi: 10.1007/s00064-020-00689-1 [Article in German]
Address for correspondence:
194044, Russian Federation,
St. Petersburg, Academician Lebedev, d. 6,
S.M. Kirov Military Medical Academy,
Department of Operative Surgery
(with Topographic Anatomy) Saint Petersburg, Russian Federation,
tel. +7 905 260-49-44,
e-mail: nachmed82@mail.ru,
Nisht Alexey Y.
Information about the authors:
Nisht Aleksey Y., PhD, Associate Professor, Doctoral Student of the Department of Operative Surgery (with Topographic Anatomy), S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Russian Federation.
https://orcid.org/0000-0002-6696-1897
Fomin Nikolai F., MD, Professor, Head of the Department of Operative Surgery (with Topographic Anatomy), S.M. Kirov Military Medical Academy of the Ministry of Defense of the Russian Federation, St. Petersburg, Russian Federation.
https://orcid.org/0000-0003-3961-1987
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