Year 2021 Vol. 29 No 6

GENERAL & SPECIAL SURGERY

E.A. ILYICHEVA 1, D.A. BULGATOV 1, T.A. ROY 1, D.V. LEBEDEVA 2

CHANGES OF QUALITY OF LIFE AFTER SURGICAL TREATMENT OF SECONDARY HYPERPARATHYROIDISM IN PATIENTS UNDERGOING RENAL REPLACEMENT THERAPY WITH HEMODIALYSIS

Irkutsk Scientific Center of Surgery and Traumatology 1,
Irkutsk State Medical University 2, Irkutsk,
The Russian Federation

Objective. To assess quality of life (QoL) using the Short Form Medical Outcomes Study (SF-36) questionnaire before and after surgical treatment of secondary hyperparathyroidism (SHPT) in patients undergoing renal replacement therapy.
Methods. QoL was assessed before surgery and in the period from 4 to 30 months after surgical treatment of SHPT. Twenty patients were questioned according to SF-36 questionnaire in a longitudinal study and in comparison, with the population indicators of the Irkutsk region residents. The median age before surgery was 53 years, the median level of PTH before surgery was 1715 pg/ml. After surgical treatment, the median of PTH was 12.9 pg/ml, calcium 1.99 mmol/l; phosphorus 1.72 mmol/l within 6-12 months.
Results. An unfavorable effect of SHPT on QoL of patients receiving hemodialysis was shown in comparison with population indicators. Evaluation of the effectiveness of surgical treatment of SHPT in relation to changes in the quality of life of patients is given. A statistically significant increase in QoL indicators after surgical treatment was proved for all the studied scales (pW<0.05). In the long term after the operation, QoL of patients receiving hemodialysis exceeds the population indicators on the scales of the psychological component of health, pain intensity, social and role functioning.
Conclusion. The SHPT in patients receiving hemodialysis is the cause of a decrease in QoL in comparison with population indicators was shown for the first time. Surgical remission of the disease leads to a statistically significant improvement in QoL, and on the scales of the psychological component of health, intensity of pain, social and role functioning, the quality of life of patients exceeds population indicators in a similar age group. The data obtained allow us to consider postoperative hypoparathyroidism as one of the favorable factors in course of postoperative period and criterion for remission of the disease.

Keywords: parathyroidectomy, secondary hyperparathyroidism, quality of life, SF-36, chronic kidney disease, postoperative hypoparathyroism, PTH
p. 654-661 of the original issue
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Address for correspondence:
664003, Russian Federation,
Irkutsk, Borcy Revoljucii Str., 1,
Irkutsk Scientific Center of Surgery
and Traumatology
tel.: 8(3952)40-78-28,
-mail: lena_isi@mail.ru
Ilyicheva Elens A.
Information about the authors:
Ilyicheva Elena A., MD, Professor, Head of the Research Department of Clinical Surgery, Irkutsk Scientific Center of Surgery and Traumatology, Irkutsk, Russian Federation.
https://orcid.org/0000-0002-2081-8665
Bulgatov Dmitry A., Senior Researcher of the Research Department of Clinical Surgery, Irkutsk Scientific Center of Surgery and Traumatology, Irkutsk, Russian Federation.
https://orcid.org/0000-0002-2440-0813
Roy Tatyana A., Senior Researcher of the Research Department of Clinical Surgery, Irkutsk Scientific Center of Surgery and Traumatology, Irkutsk, Russian Federation.
https://orcid.org/0000-0002-3273-774X
Lebedeva Darya V., Day Time Post-Graduate Student of the Hospital Surgery DEpartment, Irkutsk State Medical University, Irkutsk, Russian Federation.
https://orcid.org/0000-0001-7388-1679
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