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Khirurgii

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Year 2020 Vol. 28 No 4

REVIEWS

V.V. POVOROZNYUK, N.V. DEDUKH, M.A. BYSTRYTSKA

VITAMIN D IN BONE REGENERATION: FROM EXPERIMENTAL RESEARCH TO CLINICAL PRACTICE

D. F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kiev
Ukraine

Vitamin D has a pleiotropic effect, affecting the organs and tissues of the body. It affects the bone tissue by controlling calcium and phosphates homeostasis, as well as by direct affect on the bone tissue cells and their metabolism. The study of bone regeneration under conditions of vitamin D deficiency is under active research. The literature review summarizes the mechanisms of vitamin D action on a bone, the features of bone regeneration and the role of vitamin D deficiency at the stages of regeneration (inflammation, the formation of soft and hard regenerates with its subsequent remodeling). It is noted that the data presented in the literature are fragmented, but make it possible to evaluate vitamin D significance in this complex process. Data from experimental animal studies indicate that in most of the studies, the addition of vitamin D to diet of the animals with experimentally modeled traumatic damage contributed to the formation of full-fledged regeneration. We examined the results of clinical trials in three aspects: the prevalence of vitamin D deficiency in patients with a fracture, the role of vitamin D in prevention and the effect of vitamin D preparations on fracture healing. A high percentage of the presence of vitamin D deficiency in patients with impaired consolidation of fragments is shown; however, with regard to the prevention of fracture risk and the treatment of patients with fractures, the data are contradictory, which prompts further research in this direction.

Keywords: vitamin D, deficiency, risk of fracture, bone regeneration, experimental studies, clinical observations
p. 428-438 of the original issue
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Address for correspondence:
04114, Ukraine,
Kiev, Vushgorodskaja str., 67,
D. F. Chebotarev Institute
of Gerontology of the National Academy
of Medical Sciences of Ukraine,
the Department of Clinical Physiology
and Pathology of the Musculoskeletal System
tel. +380 97 664-80-65,
e-mail: dedukh_ninel@ukr.net,
Dedukh Ninel Vasilyevna
Information about the authors:
Povoroznyuk Vladyslav V., MD, Professor, Honored Worker of Science and Technology of Ukraine, Head of the Department of Clinical Physiology and Pathology of the Musculoskeletal System, D. F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kiev, Ukraine.
https://orcid.org/0000-0002-8855-482X
Dedukh Ninel V., MD, Leading Researcher of the Department of Clinical Physiology and Pathology of the Musculoskeletal System, D. F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kiev, Ukraine.
https://orcid.org/0000-0003-0307-2328
Bystrytska Maryna A., PhD, Senior Researcher of the Department of Clinical Physiology and Pathology of the Musculoskeletal System, D. F. Chebotarev Institute of Gerontology of the National Academy of Medical Sciences of Ukraine, Kiev, Ukraine.
https://orcid.org/0000-0001-7755-1247
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