This journal is
indexed in Scopus
Year 2020 Vol. 28 No 2
A.O. NYKONENKO 1,2, O.S. NYKONENKO 1, D.A. BUGA 2, I.V. RUSANOV 2, S.R.VILDANOV 1
HEALTH STATUS ASSESSMENT OF RELATED KIDNEY DONORS IN THE LATE POSTOPERATIVE PERIOD
Zaporizhzhya State Medical University 1,
Zaporizhzhya Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine 2, Zaporizhia,
Objective. To analyze the health status of living kidney donors based on the degree of restoration of the kidney function and the general physical status of the donor.
Methods. 37 related kidney donors underwent nephrectomy between 2014 and 2017. The average age was 48.3±9.7 (Ì±σ) years, with 19 men (51%) and 18 (49%) women. In the late postoperative period (1,9±1,1 years (Ì±σ)), the levels of proteinuria, and glomerular filtration rate (GFR) were studied. The life quality of kidney donors was assessed using the Medical Outcomes Study-Short Form-36 questionnaire.
Results. The average GFR before the operation was 78,9±24,5 ml/min per 1.73 m2, and fell to 49,8±11,2 ml/min per 1.73 m2 on the 2nd day after the operation. Upon discharge (15,2±7,0 day), average GFR increased to 53,4±8,0 ml/min per 1.73 m2, and almost reached pre-operation levels 1,9±1,1 years after the operation. This suggests that a single normally-functioning kidney is capable of taking on the load from the missing kidney. Furthermore, our study showed that, in the late postoperative period, there was no statistically significant difference in either GFR or quality of life between the donors of different age groups (p>0.05). Our research showed that if adequate protocols are used for living donor selection, donor-recipient kidney transplantation is not only an effective method for treating terminal stage of chronic end stage of renal disease, but is also safe for health and the subsequent renal function of the donor.
Conclusions. In living donors, a gradual restoration of renal function is observed, according to GFR, at discharge (day 15.2±7.0) and in the late postoperative period (1.9±1.1 years), almost reaching the preoperative level. The physical and psychological health components of donors of different age groups were comparable.
- Gautier SV, Konstantinov VK. Assessment Methods of Quality of Life of Living Organ Donors. Russian Journal of Transplantology and Artificial Organs. 2017;19(1):82-88. doi: 10.15825/1995-1191-2017-1-82-88 (In Russ.)
- Lentine KL, Kasiske BL, Levey AS, Adams PL, Alberú J, Bakr MA, Gallon L, Garvey CA, Guleria S, Li PK, Segev DL, Taler SJ, Tanabe K, Wright L, Zeier MG, Cheung M, Garg AX. KDIGO clinical practice guideline on the evaluation and care of living kidney donors. Transplantation. 2017 Aug;101(8S Suppl 1):S1-S109. doi: 10.1097/TP.0000000000001769
- Levey AS, Inker LA. GFR evaluation in living kidney donor candidates. J Am Soc Nephrol. 2017 Apr;28(4):1062-71. Published online 2017 Mar 15. doi: 10.1681/ASN.2016070790
- Inker LA, Koraishy FM, Goyal N, Lentine KL. Assessment of glomerular filtration rate and end-stage kidney disease risk in living kidney donor candidates: a paradigm for evaluation, selection, and counseling. Adv Chronic Kidney Dis. 2018 Jan;25(1):21-30. doi: 10.1053/j.ackd.2017.09.002
- Mehta KS, Swami R, Pajai A, Bhurke S, Shirkande A, Jawle S. Long-term evaluation of kidney function in live-related kidney donors. Saudi J Kidney Dis Transpl. 2017 Sep-Oct;28(5):1041-49. doi: 10.4103/1319-2442.215145
- Janki S, Dols LFC, Timman R, Mulder EEAP, Dooper IMM, van de Wetering J, IJzermans JNM. Five-year follow-up after live donor nephrectomy - cross-sectional and longitudinal analysis of a prospective cohort within the era of extended donor eligibility criteria. Transpl Int. 2017 Mar;30(3):266-76. doi: 10.1111/tri.12872
- Han X, Lim JY, Raman L, Tai BC, Kaur H, Goh AT, Vathsala A, Tiong HY. Nephrectomy-induced reduced renal function and the health-related quality of life of living kidney donors. Clin Transplant. 2017 Mar;31(3). doi: 10.1111/ctr.12910
- Levey AS, Inker LA. GFR Evaluation in Living Kidney Donor Candidates. J Am Soc Nephrol. 2017 Apr;28(4):1062-71. doi: 10.1681/ASN.2016070790
- Kasiske BL, Asrani SK, Dew MA, Henderson ML, Henrich C, Humar A, Israni AK, Lentine KL, Matas AJ, Newell KA, LaPointe Rudow D, Massie AB, Snyder JJ, Taler SJ, Trotter JF, Waterman AD. The living donor collective: a scientific registry for living donors. Am J Transplant. 2017 Dec;17(12):3040-48. doi: 10.1111/ajt.14365
- Mjøen G, Holdaas H. Long term risk of mortality after living kidney donation. BMJ. 2017 Apr 25;357:j1770. doi: 10.1136/bmj.j1770
- Boudville N, Garg AX. End-stage renal disease in living kidney donors. Kidney Int. 2014 Jul;86(1):20-22. doi: 10.1038/ki.2013.560
- O’Keeffe LM, Ramond A, Oliver-Williams C, Willeit P, Paige E, Trotter P, Evans J, Wadström J, Nicholson M, Collett D, Di Angelantonio E. Mid- and long-term health risks in living kidney donors: a systematic review and meta-analysis. Ann Intern Med. 2018 Feb 20;168(4):276-84. doi: 10.7326/M17-1235
- Muzaale AD, Massie AB, Wang MC, Montgomery RA, McBride MA, Wainright JL, Segev DL. Risk of end-stage renal disease following live kidney donation. JAMA. 2014 Feb 12;311(6):579-86. doi: 10.1001/jama.2013.285141
- Matas AJ, Vock DM, Ibrahim HN. GFR ?25 years postdonation in living kidney donors with (vs. without) a first-degree relative with ESRD. Am J Transplant. 2018 Mar;18(3):625-31. doi: 10.1111/ajt.14525
- Yalin SF, Trabulus S, Seyahi N, Cengiz M, Cicik ME, Altiparmak MR. Ambulatory blood pressure monitoring in living kidney donors: What changes in 10 years? Clin Transplant. 2018 Apr;32(4):e13224. doi: 10.1111/ctr.13224
- Wainright JL, Robinson AM, Wilk AR, Klassen DK, Cherikh WS, Stewart DE. Risk of ESRD in prior living kidney donors. Am J Transplant. 2018 May;18(5):1129-39. doi: 10.1111/ajt.14678
- Lam NN, Garg AX. Acceptability of older adults as living kidney donors. Curr Opin Nephrol Hypertens. 2016 May;25(3):245-56. doi: 10.1097/MNH.0000000000000215
Zaporizhia, pr. Mayakovskii, 26,
Zaporizhzhya State Medical University,
the hospital surgery chair,
tel. +38 (097)-594-54-93,
Nykonenko Andriy A.
Nykonenko Andriy O., Doctor of Medical Sciences (MD), Professor, Head of the Hospital Surgery Chair, Zaporizhzhya State Medical University, Zaporizhia, Ukraine.
Nykonenko Olexandr S., Doctor of Medical Sciences (MD), Professor, Academician of NAMS of Ukraine, Corresponding Member of NAS of Ukraine, Rector, Zaporizhzhya Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine , Zaporizhia, Ukraine.
Buga Dmitrii A., MD, Associate Professor, Head of the Department of Transplantology and Endocrine Surgery with the Courses of the Cardiovascular Surgery, Zaporizhzhya Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine, Zaporizhia, Ukraine.
Rusanov Ihor V., Candidate of Medical Sciences (PhD), Associate Professor of the Department of Transplantology and Endocrine Surgery with the Courses of the Cardiovascular Surgery, Zaporizhzhya Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine, Zaporizhia, Ukraine.
Vildanov Serhii R., Candidate of Medical Sciences (PhD), Assistant of the Hospital Surgery Department, Zaporizhzhya State Medical University, Zaporizhia, Ukraine.