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Year 2019 Vol. 27 No 2

REVIEWS

S.A. SUSHKOU, E.I. LEBEDEVA, O.D. MYADELETS

PERICYTES AS A POTENTIAL SOURCE OF NEOANGIOGENESIS

Vitebsk State Medical University, Vitebsk,
The Republic of Belarus

The scientific literature analysis has shown that researchers in the field of regenerative medicine consider pericytes to be a promising therapeutic target. However, there are still too many problems that require thorough investigations. One of the main tasks is the identification of pericytes. Despite numerous attempts, the molecular marker panel remains undeveloped. All markers which are used to identify pericytes are dynamic in their expression. This may be related to the stages of pericyte differentiation, peculiarities of the tissue structure, the pathological state, the hierarchy of the vessels and the stage of their development. The identification of the source of pericyte development and understanding of the processes governing their differentiation remain the problem of current interest. The mechanism of pericyte differentiation into myofibroblasts, osteoblasts, adipocytes, chondrocytes, smooth myocytes and macrophages remains insufficiently studied and debatable. There is no consensus about pericyte heterogeneity. This is the subject of further research aimed at proving pericyte heterogeneity in terms of morphology and function along the blood vessels; quantitative determination of differences in the expression of markers in different pericyte subtypes and the development of the nomenclature. The determination of phenotypic differences between pericytes during angiogenesis and in mature vessels is of particular interest. This is necessary to understand the functions of pericytes in the microvasculature. An important direction is the detailed study of signaling pathways involved in the regulation of complex interactions between pericytes and endothelial cells. This will not only expand the understanding of the pathogenesis, but also will allow introducing new methods of treatment into practical medicine.

Keywords: pericytes, morphology, origin, markers, signaling pathways, role in pathological processes
p. 212-221 of the original issue
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Address for correspondence:
210009, The Republic of Belarus,
Vitebsk, Frunze Ave., 27,
Vitebsk State Medical University,
Department of Histology,
Cytology and Embryology.
Tel. mob.: + 375 33 675 76 99,
e-mail: lebedeva.ya-elenale2013@yandex.ru,
Elena I. Lebedeva
Information about the authors:
Sushkou Siarhei A., PhD, Associate Professor, Vice-rector of Scientific and Research Affairs, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
http://orcid.org/0000-0002-7524-6182
Lebedeva Elena I., PhD, Associate Professor of the Department of Histology, Cytology and Embryology, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0003-1309-4248
Myadelets Oleg D., MD, Professor, Head of the Department of Histology, Cytology and Embryology, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0002-6781-5584
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