Year 2018 Vol. 26 No 6

SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY

O.P. CHUDAKOV 1, XIE XUKAI 1, O.A. YUDZINA 2, L.V. BUTSKO 1

MORPHOLOGICAL ASPECTS OF OSSEOINTEGRATION IN CASE OF EXPERIMENTAL CORRECTION OF TRAUMATIC DEFECTS OF FACIAL SKULL AND CEREBRAL CRANIUM BONES WITH THE HELP OF PURE TITANIUM

Belarusian State Medical University 1,
City Clinical Pathoanatomical Bureau 2, Minsk,
The Republic of Belarus

Objective. To assess the osseointegration process in reconstructive surgeries of traumatic defects of the facial skull and cerebral cranium bones with the help of pure titanium implants in experiment.
Methods. Experimental researches were conducted on same-sex rabbits (males) of Chinchilla breed (n=40). Three series were created: the first main (surgeries on lower jawbone), the second main (surgeries on frontal bone), the third comparative (without implanting). In two main series the defects of mandibular ramus bone and frontal bone were modeled. We implanted perforated plates of pure titanium into defected areas. Total time of experiment amounted to 3, 7, 14, 30, 90, 180 days and 24 months. The following aspects were studied: safety, biological inertness, local and general reaction of the body tissue to titanium implant, morphological characteristics of osteogenesis in bone-implant system, factor of implant fixation in the reparative osteogenesis.
Results. Trombogenic safety of pure titanium for myocardium and kidneys was demonstrated; parts of corroded titanium were not found in bone tissue of lower jaw and frontal bone and in a new bone graft. Pure titanium does not cause any immune reaction. In reparative osteogenesis one proved the absence of joint capsule, new bone implant fibrosis and important role of biological fixation of the implant; and also a possibility to predict the complication development in the bone-implant system was established. The perforated pure titanium implant used in the process of reparative osteogenesis activates the formation of new bone graft, facilitates all stages of bone tissue transformation: inflammation, osteoblast proliferation, collagenogenesis and ossification.
Conclusions. Research results of general reaction of the organism to pure titanium in bone-implant system prove its bio-inertness, ensuring biological fixation during implantation into the body due to the ingrowth of the bone regenerate into the perforation holes of the titanium plates without connective tissue fibrous layer.

Keywords: defect of facial skull and cerebral cranium bone, reconstructive surgery, titanium implant, osseointegration, "bone-implant" system, reparative osteogenesis process
p. 645-654 of the original issue
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Address for correspondence:
220116, The Republic of Belarus,
Minsk, Dzerzhinsky Ave.,83,
Belarusian State Medical University,
Department of Surgical Dentistry.
Tel. +375172052173,
e-mail: surgstom@bsmu.by,
Oleg P. Chudakov
Information about the authors:
Chudakov Oleg P., MD, Professor, Professor of the Department of Surgical Dentistry, Belarusian State Medical University, Minsk, Republic of Belarus.
http://orcid.org/0000-0003-4454-3093
Xie Xukai, Post-Graduate Student of the Department of Surgical Dentistry, Belarusian State Medical University, Minsk, Republic of Belarus.
http://orcid.org/0000-0001-5196-4561
Yudzina Olha A., PhD, Associate Professor, Head of the Pathoanatomical Department, City Clinical Pathoanatomical Bureau, Minsk, Republic of Belarus.
http://orcid.org/0000-0001-7623-0601
Butsko Liudmila V., PhD, Leading Veterinarian of the Experimental Biological Clinic (Vivarium), Belarusian State Medical University, Minsk, Republic of Belarus.
http://orcid.org/0000-0003-2028-4381
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