Year 2017 Vol. 25 No 6




Vitebsk State Medical University, Vitebsk
The Republic of Belarus

Objective. To study interrelation between pain syndrome intensity and nerve tissue marker neurofilament (NF) expression in pancreas at chronic pancreatitis.
Methods. The research included 45 patients with chronic pancreatitis who needed surgical intervention because of abdominal pain that could not be stopped by medications. For assessment of a pain syndrome a visual analogue scale (VAS) was used. Involvement of nervous tissue was estimated by a NF expression in the serial histological sections of resected pancreas head stained with Anti-Neurofilament Monoclonal Antibody. Control group for morphological research included 7 pancreas head samples without any pancreas pathology from age comparable people died by accidents.
Results. In patients with chronic pancreatitis the pain syndrome intensity index, estimated by VAS, varied from 2 to 10 points. A mild pain (from 1 to 3 points) was noted by 4 (9%), moderate pain (4-6 points) 17 (38%), severe pain (7-10 points) 24 (53%) patients.
Statistical assessment of a pain syndrome intensity and NF expression showed a moderate linear relationship (r=0,3, p=0,04). The research of a pain syndrome intensity and positively NF-expressing nervous elements percent also showed a moderate correlation (r=0,33; p=0,03).
Conclusions. Chronic pancreatitis is associated with a different intensity pain syndrome (from 2 to 10 points). At the same time the intensity of the pain syndrome estimated by visual analogue scale (VAS) was associated with nervous tissue qualitative characteristics changes that was confirmed by high rates of NF expression and percent of NF- positively expressing nervous elements at the severe pain syndrome.

Keywords: chronic pancreatitis, immunohistochemistry, nerve tissue, neurofilament, abdominal pain, visual analog scale
p. 567-573 of the original issue
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Address for correspondence:
210023, The Republic of Belarus,
Vitebsk, Frunze ave., 27,
EE Vitebsk State Medical University,
Department of Surgery
of the Faculty of Advanced Training and Retraining,
Tel.: +375 29 654-45-99,
Anatoliy T. Shchastny
Information about the authors:
Shchastny A.T., MD., Ass. Professor, Rector of Vitebsk State Medical University
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