Year 2016 Vol. 24 No 2




ME "Mogilev Regional Hospital",
The Republic of Belarus

Objectives. To find out the impact of age on onset times; providing conditions for the tracheal intubation and duration of cisatracurium action.
Methods. The patients (n=78) undergone to laparoscopic cholecystectomy were enrolled in the prospective study. The patients were divided into four groups according to age: group 1 (n=18) 18-39 yrs old; group 2 (n=18) 40-49 yrs old; group 3 (n=21) 50 to 59 yrs old; and group 4 (n=21) above 60 yrs old. All patients received cisatracurium 0,1-0,15 mg/kg. General anesthesia was maintained with inhalation of sevoflurane and bolus administration of fentanyl. A neuromuscular transmission was measured by kinemiography method.
Results. Onset time of cisatracurium action was significantly shorter in group 1 in comparison with groups 3 and 4: 216,588,6 c in group 1 in comparison with group 3 and 4: 284,887,4 and 306,0140,5 c, respectively, p <0,05. All patients underwent tracheal intubation at the first attempt, duration was about 180 seconds.
Duration of action of cisatracurium was not differed between the groups: in group 1 45,49,2 min, in group 2 47,69,6 min, in group 3 50,19,8 min, in group 4 46,99,8 min, p>0,1. Despite the absence of statistically significant differences in the duration of action, the recovery index of the neuromuscular block was significantly longer in groups 3 and 4 in comparison with groups 1 and 2 (group 1 12,93,3 min, group 2 12,63,1 min, group 3 17,76,6 min, group 4 17,85,9 min, p<0,05).
Conclusion. In elderly patients neuromuscular blockade occurs more slowly and neuromuscular transmission restored at the same time compared with young patients.

Keywords: muscle relaxants, cisatracurium, neuromuscular block, neuromuscular transmission, general anaesthesia, tracheal intubation, inhalation
p. 170-176 of the original issue
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Address for correspondence:
212002, the Republic of Belarus,
g. Mogilev, ul. B. Biruli, d. 12,
UZ "Mogilevskaya oblastnaya bolnitsa",
otdelenie anesteziologii i reanimatsii, 375 222 27-87-33,212002,
Lipnitski Artur Leonidovich
Information about the authors:
Marochkov A.V. MD, professor, a head of anaesthesiology and intensive care unit of ME "Mogilev Regional Hospital".
Lipnitski A.L. A head of transplant-coordination unit of ME "Mogilev Regional Hospital".
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