Novosti
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Year 2014 Vol. 22 No 3
GENERAL AND SPECIAL SURGERY
M.Y. YURIEVA, Y.S. VINNIK, E.N. ANISIMOVA, A.B. SALMINA, O.V. TEPLYAKOVA, N.G. TRETYAKOVA
THE EFFECT OF SYSTEM OZONE THERAPY ON THE LEVEL OF VON WILLEBRAND FACTOR PRODUCTION IN LOCAL COLD
SBEE “Krasnoyarsk State Medical University named after professor V.F. Voino-Yasnetsky”,
The Russian Federation
Objectives. To study the effect of the systemic ozone therapy on von Willebrand factor antigen content in the blood plasma in patients suffering from local cold injury.
Methods. Sixty patients with a local cold injury (II-IV stages) in the prereactive and early reactive period were enrolled in the study. The first group (n=20) included patients suffering from frostbite, receiving a standard basic treatment. The second group of patients (n=20) along with a basic treatment the intravenous infusions of the ozonated physiological saline solution has been added. The third group was composed of the patients (n=20) received a major ozonated autohemotherapy on the background of basic treatment. The control group consisted of healthy persons (20-60 yrs. old, males and females (n=20). To determine von Willebrand factor antigen level (vWf) in plasma an enzyme-linked immunosorbent assay (ELISA) has been applied.
Results. The von Willebrand factor antigen level in blood plasma of healthy persons (20-60 yrs. old, males and females (n=20) was within 0,69±0,31 IU / ml. The study marker value in patients suffering from frostbite at hospitalization exceeded the same in the control group. On the 10th day the level of the analyzed marker didn’t change significantly on the background of basic treatment (the 1st group). The significant reduction of the vWF was registered in patients receiving systemic ozone therapy on the background of basic treatment (ð<0,0001). Besides, on the 10th day vWF level was significantly lower in patients of the third group receiving a major ozonated autohemotherapy than in patients treated with intravenous infusions of ozonated physiological saline solution.
Conclusions. The application of systemic ozone therapy in complex treatment of patients suffering from local cold injury contributes to reduction of von Willebrand factor antigen level in blood plasma.
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660022, Rossiyskaya Federatsiya, g. Krasnoyarsk, ul. P. Zheleznyaka, d. 1, GBOU VPO «Krasnoyarskiy gosudarstvennyiy meditsinskiy universitet imeni professora V.F. Voyno-Yasenetskogo», kafedra obschey khirurgii,
e-mail: yuvinnik@yandex.ru,
Vinnik Yuriy Semyonovich
Yurieva M.Yu. A post-graduate student of the general surgery chair of SBEE HPE Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky”.
Vinnik Yu.S. MD, professor, a head of the general surgery chair of SBEE HPE Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky”.
Anisimova E.N. MD, professor, a head of the clinical-laboratory diagnostics chair of SBEE HPE Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky”.
Salmina A.B. MD, professor, a head of the SRI of Molecular Medicine and Pathobiochemistry of SBEE HPE Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky”.
Teplyakova O.V. PhD, an associate professor of the general surgery chair of SBEE HPE Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky”.
Tretyakova N.G. A six-year student of the medical faculty of SBEE HPE Krasnoyarsk State Medical University named after professor V.F. Voino-Yasenetsky”.
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