This journal is
indexed in Scopus
Year 2013 Vol. 21 No 4
GENERAL AND SPECIAL SURGERY
A.G. SALMANOV 1, V.F. MARIEVSKY2
ANTIBIOTIC RESISTANCE OF NOSOCOMIAL STRAINS OF STAPHYLOCOCCUS AUREUS IN THE UKRAINE: THE RESULTS OF MULTICENTER STUDY
State Sanitary and Epidemiological Department of the Ukraine1
SE «Institute of Epidemiology and Infectious Diseases named after L.V.Gromashevsky of National Academy of Medical Siences of the Ukraine2», Kiev,
Objectives. To study the activity of antimicrobials against clinical strains of S.aureus isolated in the surgical hospitals of different regions of the Ukraine.
Methods. The clinical strains of S.aureus (119041) isolated in 2008-2012 yrs in 97 surgical hospitals of 27 regions of the Ukraine have been studied. Clinical isolates were allocated and identified in 83 microbiological laboratories included in the research of medical establishments. The material for the epidemiological study was the data of the laboratory journals of the examined surgical hospitals of the Ukraine. S.aureus susceptibility to 37 antibiotics was investigated by the disc-diffusion test in accordance with the recommendations of the National Committee for Clinical laboratory Standards (NCCLS).
Results. The highest activity to S.aureus had linezolid, imipenem, vancomycin, meropenem, ceftriaxone, ciprofloxacin, netilmicin, gatifloxacin, and cefotaximum. The high rates of resistance were registered for penicillin (48,3%), ampicillin (41,2%), tetracycline (40,1%), ampicillin/sulbactam (35,2%), and to lincomycin (34,5%). The frequency of isolation of MRSA among tested strains was 33,8% varying from 20,7% to 55,8% in surgical hospitals of different regions.
Conclusions. Antibiotic resistance to S.aureus in surgical hospitals, being a subject of the research is considered to be a serious therapeutic and epidemiologic problem. Taking into account the constant changes and significant differences of the S.aureus resistance levels observed in various regions, the constant monitoring of antibiotic resistance to antimicrobials in every in-patient medical institution is required and on the base of the local obtained results to elaborate the hospital record sheets. Antibiotics application tactics should be determined in accordance with the local data of resistance to them in each surgical in-patient institution. The system of epidemiologic surveillance over microbial resistance should be established on the local, regional, and national levels.
- Suggested citation: European Centre for Disease Prevention and Control. Surveillance of surgical site infections in Europe, 2008–2009. Stockholm: ECDC; 2012. Available from: http://www.ecdc.europa.eu.
- The evolving threat of antimicrobial resistance – Options for action. Geneva, SW: World Health Organization; 2012. Available from: http://www.who.int.
- European Centre for Disease Prevention and Control. Antimicrobial resistance surveillance in Europe 2011. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net). Stockholm: ECDC; 2012. Available from: http://ecdc.europa.eu.
- Salmanov A. Surgical site infections and antibiotic resistance of causal agents in the hospitals of Kiev, Ukraine. EpiNorth. 2009;10(3):120–27.
- Fry DE. The continued challenge of Staphylococcus aureus in the surgical patient. Am Surg. 2013 Jan;79(1):1–10.
- Takesue Y, Watanabe A, Hanaki H, Kusachi S, Matsumoto T, Iwamoto A, Totsuka K, Sunakawa K, Yagisawa M, Sato J, Oguri T, Nakanishi K, Sumiyama Y, Kitagawa Y, Wakabayashi G, Koyama I, Yanaga K, Konishi T, Fukushima R, Seki S, Imai S, Shintani T, Tsukada H, Tsukada K, Omura K, Mikamo H, Takeyama H, Kusunoki M, Kubo S, Shimizu J, Hirai T, Ohge H, Kadowaki A, Okamoto K, Yanagihara K. Nationwide surveillance of antimicrobial susceptibility patterns of pathogens isolated from surgical site infections (SSI) in Japan. J Infect Chemother. 2012 Dec;18(6):816–26.
- Li H, Yu DL, Ren L, Zhong L, Peng ZH, Teng MJ. Analysis of Gram-positive bacterial infection in patients following liver transplantation. Chin Med J (Engl). 2012 Jul;125(14):2417–21.
- Cheong CS, Tan LM, Ngo RY. Clinical audit of the microbiology of otorrhoea referred to a tertiary hospital in Singapore. Singapore Med J. 2012 Apr;53(4):244–48.
- Gagliotti C, Balode A, Baquero F, Degener J, Grundmann H, Gur D, Jarlier V, Kahlmeter G, Monen J, Monnet DL, Rossolini GM, Suetens C, Weist K, Heuer O. Escherichia coli and Staphylococcus aureus: bad news and good news from the European Antimicrobial Resistance Surveillance Network (EARS-Net, formerly EARSS), 2002 to 2009. Euro Surveill. 2011 Mar 17;16(11). pii: 19819.
- Salmanov AG, Lazorishchinets' VV, Mar³ºvs'kii VF. Antib³otikorezistentn³st' kl³n³chnikh shtam³v Staphylococcus aureus v kh³rurg³chnikh stats³onarakh Ukra¿n³ v 2010 r [Antibiotic resistance of Staphylococcus aureus strains in surgical hospitals in Ukraine in 2010]. Kh³rurg³ia Ukra¿n³. 2011;(3):26–31.
- Mar³ºvs'kii VF, Poliachenko IuV, Salmanov AG, Shpak ²V, Doan S². Antib³otikorezistentn³st' nozokom³al'nikh shtam³v Staphylococcus aureus v kh³rurg³chnikh stats³onarakh Ukra¿ni v 2009 r [Antibiotic resistance of nosocomial Staphylococcus aureus strains in surgical hospitals in Ukraine in 2009 ]. Kl³n³chna kh³rurg³ia. 2010;(9):31–35.
- National Committee for Clinical Laboratory Standards. Performance standards for antimicrobial susceptibility testing; Twelfth informational supplement. NCCLS. Document M100 S4. 2002;22(1).
01601, Ukraina, g. Kiev, ul. Grushevskogo, d. 7, Gosudarstvennaia sanitarno-epidemiologicheskaia sluzhba Ukrainy,
Salmanov Aidyn Gurbanovich
Salmanov A.G. PhD, a chief specialist of State Sanitary and Epidemiological Department of the Ukraine.
Marievsky V.F. MD, professor, a head of laboratory of disinfectology of SE “Institute of Epidemiology and Infectious Diseases named after L.V.Gromashevsky of NAMS of the Ukraine”.