Year 2013 Vol. 21 No 1




Azerbaijan Medical University, Baku1,
The Republic Azerbaijan
SBEE HPE Kursk State Medical University 2,
The Russian Federation

Objectives. To study the morphological changes in the anterior abdominal wall tissues in the fixation zone of the lavsan and polypropylene prosthesis.
Methods. Experimental investigations were made on 40 mice (20 animals in each series). The animals were subdivided into 2 groups: the 1st group with the lavsan prosthesis use; in the 2nd group with the polypropylene prosthesis. Histological examination of the muscular-aponeurotic fragments combined with the synthetic materials with staining of the preparations by hematoxylin and eosin and according to Van-Gizon method was conducted on the 10th, 30th and 60th day.
Results. While performing the comparative analysis of the macrophage reaction in the connective tissue, significantly more number of macrophages in the surrounding connective tissue were registered at the lavsan prosthesis implantation between two groups of animals that testified to more foreignness of the given material.
In comparison of the segmented leukocytes dynamics in the 2nd group we found out a reliable decrease of the leukocytes number at the percentage ratio stabilization of fibroblasts and macrophages versus the earlier terms that proved the reduction of the inflammatory process intensity as well as intensification of the repair processes.
In both series of the experiment the lymphocytic reaction analysis indicated the growth of the immune response in terms up to 1 month with its subsequent reduction in the 1st group and the stable manifestation in the 2nd group.
The particular significance is considered to be a comparative characteristics of a fibroblastic reaction as a mechanism of formation of protective fence off capsule of the foreign body which is in fact any endoprosthesis.
The research showed a stable formation of the connective tissue in the 2nd group. In the case when the lavsan endoprosthesis is used the formation of the connective-tissue capsule has delayed caused by the inflammatory processes.
Conclusions. On the basis of the conducted experiment the low biocompatibility of the lavsan prosthesis was established in comparison with the polypropylene prosthesis. Therefore the use of polypropylene implant is considered to be preferable in clinical practice.

Keywords: polypropylene prosthesis, lavsan prosthesis, endoprosthetics of anterior abdominal wall
p. 23 28 of the original issue
  1. Zhebrovskii VV. Khirurgiia gryzh zhivota [Surgery of abdominal hernia]. Moscow, RF: MIA; 2005. 384 p.
  2. Lukomskii GI, Shulutko AM, Antropova NV. Perspektivy razvitiia abdominoplastiki sinteticheskimi protezami [Prospects for the development of abdominoplasty by synthetic prostheses]. Khirurgiia. 1994;(5):5354
  3. Toskin KD, Zhebrovskii VV. Gryzhi briushnoi stenki.[Hernia of the abdominal wall]. Moscow, RF: Meditsina; 1990. 270 p.
  4. Ahmad M, Niaz WA, Hussain A, Saeeduddin A. Polypropylene mesh repair of incisional hernia. J Coll Physicians Surg Pak. 2003 Aug;13(8):44042.
  5. Timoshin AD, Iurasov AV, Shestakov AL. Khirurgicheskoe lechenie pakhovykh i posleoperatsionnykh gryzh briushnoi stenki [Surgical treatment of inguinal hernias and postoperative abdominal wall]. Moscow, RF: Triada X; 2003. 144 p.
  6. Maistrenko NA, Tkachenko AN. Negativnye posledstviia khirurgicheskogo lecheniia posleoperatsionnykh ventral'nykh gryzh. Vozmozhnosti prognoza i profilaktik [The negative consequences of surgical treatment of postoperative ventral hernias. The prognosis and prevention]. Vestn Khirurgii. 1998;154(4):13036.
  7. Timoshin AD, Shestakov AL, Kolesnikov S.A. Alloplastika obshirnoi i gigantskoi posleoperatsionnoi gryzhi briushnoi stenki [Alloplastics of large and giant postoperative abdominal wall hernia]. Klin Khirurgiia. 2003;(11):31.
  8. Bueno Lledo J, Sosa Quesada Y, Gomez I Gavara I, Vaque Urbaneja J, Carbonell Tatay F, Bonafe Diana S, Garcia Pastor P, Baquero Valdelomar R, Mir Pallardo J. Prosthetic infection after hernioplasty. Five years experience. Cir Esp. 2009 Mar;85(3):15864.
  9. Farmer L, Ayoub M, Warejcka D, Southerland S, Freeman A, Solis M. Adhesion formation after intraperitoneal and extraperitoneal implantation of polypropylene mesh. Am Surg. 1998 Feb;64(2):14446.
  10. Matyja A, Solecki R, Heitzman J. Local reaction to polypropylene mesh histopatological findings. Hernia recurrences: 26 international congress of the European Hernia Society. Praga, 2004. p. 63.
Address for correspondence:
AZ1065, Respublika Azerbaidzhan, g. Baku, ul. Bakikhanova, d. 23, Azerbaidzhanskii meditsinskii universitet, kafedra khirurgicheskikh boleznei 3,
Mamedov Ruslan Aidyn ogly
Information about the authors:
Mammadov R.A. PhD, assistant of the surgical diseases chair 3 of Azerbaijan Medical University, post-graduate student of the surgical diseases chair 1 (2007 2009 years) of SBEE HPE Kursk State Medical University.
Contacts | ©Vitebsk State Medical University, 2007-2023