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Year 2012 Vol. 20 No 1
GENERAL AND SPECIAL SURGERY
E.V. DYABKIN, YU.S. VINNIK, S.S. DUNAYEVSKAYA
DEVELOPMENTAL PECULIARITIES OF IMMUNODEFICIENCY CONDITION IN PATIENTS WITH MECHANICAL JAUNDICE OF NON-TUMOR GENESIS
SBEE HPE “Krasnoyarsk State Medical University named after professor V.F.Voyno-Yasenetsky”,
the Russian Federation
Objectives. To carry out analysis of the immune status changes in patients with the mechanical jaundice of non-tumor genesis.
Methods. 90 patients with the mechanical jaundice of non-tumor genesis were examined. The main causes of the disease were choledocholithiasis and strictures of the common bile duct. Control group included 20 practically healthy people at the age of 21-50 (10 females and 10 males).
Immune status estimation in patients with the mechanical jaundice and in those from the control group was done on hospitalization in the 1st, 5th days and on discharge from the hospital. The parameters of leukograms of the cellular, humoral elements of immunity, circulating immune complexes and phagocytosis activity were used to estimate the immune status.
Results. Changes in the immune status of patients with the mechanical jaundice of non-tumor genesis were revealed characterized by the marked lymphopenia and T-cell component suppression. The severity of immunodeficiency state is proved to correlate directly with the degree of patient’s severity.
Conclusions. The immunity state in patients with the mechanical jaundice of non-tumor genesis is connected with the secondary immunodeficiency revealed through reduction in number of the immunocompetent cells of the cellular link, their functional unbalance and insufficient decrease of the immunity humoral link function. Severity of these disturbances depends on the severity degree of the mechanical jaundice.
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660022, Rossiiskaia Federatsiia, g. Krasnoiarsk, ul. Partizana Zhelezniaka, d. 1, ÃÁÎÓ ÂÏÎ “Krasnoiarskii gosudarstvennyi meditsinskii universitet”, kafedra obshchei khirurgii,
Dyabkin Evgenii Vladimirovich
Dyabkin E.V. Candidate of medical sciences, Assistant of the general surgery chair of state budgetary educational establishment of higher professional education “Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky”.
Vinnik YU.S. Doctor of medical sciences, professor, head of the general surgery chair of state budgetary educational establishment of higher professional education “Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky”.
Dunayevskaya S.S. Candidate of medical sciences, Associate Professor of the general surgery chair of state budgetary educational establishment of higher professional education “Krasnoyarsk State Medical University named after professor V.F. Voyno-Yasenetsky”.