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Year 2010 Vol. 18 No 3

ONCOLOGY

YABLONSKY P.K., PAVLUSHKOV E.V., PETROV A.S., PISCHIK V.G., KOZAK A.R., NOKHRIN A.V.

EVALUATION OF THE REGIONAL METASTATIC SPREADING OF THE NON-SMALL CELL LUNG CANCER COMPLICATED BY THE SECONDARY INFLAMMATORY PROCESS

Objectives. Estimation of the diagnostic value of the computer tomography and mediastinoscopy at complications of the non-small cell lung cancer course (NSCLC) with the secondary inflammatory process.
Methods. The retrospective analysis of the treatment results of 365 patients operated on with NSCLC was carried out. In 280 of them the course of cancer was without the signs of the infection; in 85 of them the secondary inflammatory changes of the lung tissue were revealed. On the ground of the patients’ inspection results before the operation and the data of the pathological-anatomical investigation of the operative material the diagnostic value of the CT and mediastinoscopy was estimated in the evaluation of the regional metastasis spreading of NSCLC.
Results. The presence of the secondary inflammatory process practically doesn’t influence the CT sensitivity in the evaluation of N criterion; at the same time the specificity is significantly lower and it results in the reduction of the general diagnostic accuracy of CT informational content of mediastinoscopy doesn’t depend on the presence of the secondary inflammation (accuracy – 89,7% and 91,7% in the groups compared).
Conclusion. The secondary inflammation at NSCLC reduces the diagnostic value of CT in the evaluation of the metastasis lesion of the intrathoracic lymphatic nodes; though the accuracy of mediastinoscopy remains high.

Keywords: non-small cell lung cancer, complications, staging
p. 103 – 111 of the original issue
References
  1. Mountain, C. F. Revisions in the international system for staging lung cancer / C. F. Mountain // Chest. – 1997. – Vol. 111. – Р. 1710-1717.
  2. Improving the inaccuracies of clinical staging of patients with NSCLC: a prospective trial / R. J. Cerfolio [et al.] // Ann. Thorac Surg. – 2005. – Vol. 80, N 4. – Р. 1207-1213.
  3. Бисенков, Л. Н. Хирургия далеко зашедших и осложненных форм рака легкого / Л. Н. Бисенков. – СПб.: Деан, 2006. – 432 с.
  4. New aspects in the staging of lung cancer. Prospective validation of the International Union Against Cancer TNM classification / H. Bulzebruck [et al.] // Cancer. 1992. – Vol. 70, N 5. – Р. 1102-1110.
  5. Normal mediastinal lymph nodes: number and size according to American Thoracic Society mapping / G. M. Glazer [et al.] // Am. J. Roentgenol. – 1985. – Vol. 144, N 2. – Р. 261-265.
  6. R: A language and environment for statistical computing // R Foundation for Statistical Computing, Vienna, Austria [Electronic resourse]. – 2008. – Mode of access: http://www.r-project.org. – Date of access: 10.05.2009.
  7. Coomarasamy A. Meta-DiSc: a software for meta-analysis of test accuracy data / J. Zamora [et al.] // BMC Medical Research Methodology [Electronic resourse]. –2006. – Mode of access: http://www.hrc.es/investigacion/metadisc_en.htm. – Date of access: 10.05.2009.
  8. Bronchogenic carcinoma: analysis of staging in the mediastinum with CT by correlative lymph node mapping and sampling / T. C. McLoud [et al.] // Radiology. – 1992. – Vol. 182, N 2. – Р. 319-323.
  9. Кузнецов, И. М. Рак легкого, осложненный воспалительными и гнойно-деструктивными изменениями в легочной паренхиме и грудной полости: автореф. дис. … д-ра. мед. наук / И. М. Кузнецов. – СПб., 2005. – 40 c.
  10. Invasive staging of non-small cell lung cancer—a prospective study / S. Eggeling [et al.] // Eur. J. Cardiothorac. Surg. – 2002. – Vol. 22, N 5. – Р. 679-684.
  11. Invasive staging of non-small cell lung cancer: a review of the current evidence / E. M. Toloza [et al.] // Chest. 2003. – Vol. 123, N 1. – Suppl. – Р. 157S-166S.
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