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Khirurgii

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Year 2023 Vol. 31 No 2

SCIENTIFIC PUBLICATIONS

A.I. DOVNAR

LONG-TERM RESULTS OF CRANIOPLASTY USING BELARUSIAN COMPOSITE MATERIAL IN THE EXPERIMENT

Grodno State Medical University, Grodno, Republic of Belarus

Objectives. To study the possibility of using the Belarusian composite material «Superfluvis» as a means of replacing the bone tissue of the skull in an experiment.
Material and Methods. To study the possibility of using the Belarusian composite material «Superfluvis» as a means of replacing the bone tissue of the skull in an experiment. The study was carried out on 18 mongrel rabbits of both sexes, homogeneous in weight and age. Rabbits underwent experimental trepanation of the skull with its plastic closure with the material «Superfluvis» (group «experience-1»), titanium (group «control») and without closing the trepanation defect (group «experience-2»). The animals were removed 180 days after the operation. Before removal, venous blood was taken to study the indicators of biochemical blood analysis and the mass of animals was measured. During the autopsy, the mass coefficients of the internal organs were calculated and a histological study of the internal organs, as well as the brain and its membranes, was carried out.
Results. Analysis of the results of biochemical analysis of rabbit blood showed a statistically significant low AST level on 180 days after surgery in the «experience-1» group relative to the «control» groups (p<0.05) and «experience-2» (p<0.05). At the same time, there is no statistically significant decrease in the AST index in the «experience-1» group on 180 days after surgery with preoperative values. There is a tendency to increase glucose levels 180 days after surgery to preoperative values in the group «experience-2» (p=0.08). Statistically significant differences in other indicators of the same name of biochemical blood analysis in the studied groups were not found in these terms. Calculations of the mass coefficients of the heart, lung, right and left kidney, spleen and thymus in all the studied groups of animals did not reveal statistically significant differences between the groups of rabbits. However, there was a significant increase in the liver mass coefficient in rabbits in the «control» group in comparison with the «experiment-1» group (p=0.022). There was no statistically significant increase in the mass coefficient of the liver between the groups of animals «control» and «experiment-2».
Conclusion. The composite material «Superfluvis» does not have a toxic effect on the vital organs of the experimental animal with prolonged use (180 days).

Keywords: composite material, skull defect, titanium, mass coefficient, rabbits
p. 89-97 of the original issue
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Address for correspondence:
230009, Republic of Belarus,
Grodno, Gorky Str., 80,
Grodno State Medical University,
the Department of Neurology
and Neurosurgery,
tel. +375 297 890265,
e-mail: dovnarneiro@gmail.com,
Dovnar Àndrei I.
Information about the authors:
Dovnar Andrei I., Assistant of the Department of the Department of Neurology and Neurosurgery, Grodno State Medical University, Grodno, Republic of Belarus.
http://orcid.org/0000-0001-5535-2036
Contacts | ©Vitebsk State Medical University, 2007-2023