Year 2023 Vol. 31 No 3

SCIENTIFIC PUBLICATIONS

V.V. BESCHASTNOV, V.V. ANTOSHINA, N.YU. ORLINSKAYA, A.A. TULUPOV, I.E. POGODIN, M.G. RYABKOV

SKIN MICROTRANSPLANTATION ACCELERATES WOUND HEALING DUE TO INCREASED PROCESSES OF PROLIFERATION AND VASCULARIZATION

Privolzhskiy Research Medical University, Nizhny Novgorod, Russian Federation

Objective. Comparison of regenerative processes in wound tissue in the cases when it is closed with a split-thickness skin graft and split-thickness skin micrograft by the proposed method.
Methods. The study was performed on 15 animals (rats). In the back area of each animal, two grade III burn wounds were simulated, one of which was covered with split-thickness skin micrograft (main group), and the other with a solid split-thickness skin graft (control group). On the 7th, 14th, and 21st days, planimetric studies were performed, then the wound tissues were excised, followed by histological and immunohistochemical (Ki-67, CD31) studies.
Results. Split-thickness skin grafts are versatile adjuncts to wound closure in burns . During split-thickness skin micrograft, the processes of angiogenesis and proliferation of newly formed epithelial tissue in the area of the wound defect are stimulated. The newly formed integumentary tissue during split-thickness skin micrograft is more similar in structure to intact skin compared to plastic closure with a solid split autodermotransplant.
Conclusion. The hydrogel coating ensures the preservation of their regenerative properties. Split-thickness skin grafts are versatile adjuncts to wound closure in burns, trauma, reconstruction, and other large wounds. Split-thickness skin micrograft is considered to be an effective technique for closing full-layer skin defects and may increase wound repair quality. The proposed method of grafting split-thickness skin to the recipient wound improves its survival. Skin transplantation using split thickness skin grafts (STSGs) is the treatment of choice in large wounds

Keywords: burn wounds, plastic closure, free skin graft, split-thickness skin graft, split-thickness skin micrograft, hydro-gel
p. 190-202 of the original issue
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Address for correspondence:
603005, Russian Federation,
Nizhny Novgorod, sq. Minin &
Pozharsky, 10/1,
Volga Research Medical University,
tel.: +79200641557,
e-mail: tulupov.a.a@yandex.ru,
Tulupov Alexander A.
Information about the authors:
Beschastnov Vladimir V., MD, Professor, Leading Researcher at the University Clinic of the Federal State Budgetary Educational Institution of Higher Education Privolzhsky Research Medical University of the Ministry of Health of Russia, Nizhny Novgorod, Russian Federation.
http://orcid.org/0000-0002-9332-3858
Antoshina Veronika V., PhD, Researcher of the Pathological Anatomy Group of the Federal State Budgetary Educational Institution of Higher Education Privolzhsky Research Medical University of the Ministry of Health of Russia, Nizhny Novgorod, Russian Federation.
http://orcid.org/0000-0003-3545-0223
Orlinskaya Natalya Y., MD, Head of the Department of Pathological Anatomy of the Federal State Budgetary Educational Institution of Higher Education Privolzhsky Research Medical University of the Ministry of Health of Russia, Nizhny Novgorod, Russian Federation.
http://orcid.org/0000-0003-2896-2968
Tulupov Aleksandr A., Junior Researcher, University Clinic of the Federal State Budgetary Educational Institution of Higher Education Privolzhsky Research Medical University of the Ministry of Health of Russia, Nizhny Novgorod, Russian Federation.
ORCID: 0000-0001-6567-7803
Pogodin Igor E., Traumatologist-Orthopedist, Head of the Burn Department (adults) of the University Clinic, Leading Researcher at the University Clinic of the Federal State Budgetary Educational Institution of Higher Education Privolzhsky Research Medical University of the Ministry of Health of Russia, Nizhny Novgorod, Russian Federation.
http://orcid.org/0000-0002-7008-4962
Ryabkov Maksim G., MD, Associate Professor, Leading Researcher, University Clinic of the Federal State Budgetary Educational Institution of Higher Education Privolzhsky Research Medical University of the Ministry of Health of Russia, Nizhny Novgorod, Russian Federation.
http://orcid.org/0000-0002-9555-190X
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