Year 2021 Vol. 29 No 3




Federal Research Center of Fundamental and Translational Medicine of the Ministry of Science and Higher Education of Russia, Institute of Molecular Pathology and Pathomorphology 1
Institute of Chemical Biology and Fundamental Medicine of the Russian Academy of Sciences, Siberian Branch2;
The Russian Federation

Objective. To study the features of scar formation and structural changes in the remaining renal parenchyma in rats after the kidney resection in various terms.
Methods. A layered closure of midline laparotomy and the caudal part of the left kidney removal was performed in rats under general inhalation ether anesthesia in a clean operating room. The morphology of the remaining kidney part after resection was studied using light microscope in different terms.
Results. A thrombus from blood leaking out of the cut vessels is formed on the damaged surface of the kidney immediately after the resection. This clot with the parenchyma is gradually replaced by the connective tissue along the edge of the defect with the subsequently formation of a thin connective or fibrous tissue scar. However, in many cases, the number of which in rats can reach 40%, the processes of kidney damage continue for a long time after surgery, and leading to total or subtotal nephrosclerosis. The detected cystic change in tubular structures, apparently, occurred firstly due to their intersection during the resection, clamping by a blood clot and / or compression by edema distal to the observation site. Then, the forming extensive scar again clamped the adjacent tubular structures with subsequent cystic degeneration and sclerosis. In this case, detritus formed from non-viable renal tissues is eliminated by macrophages, which can form multinucleated cells with fused cytoplasm.
Conclusion. Structural changes in the nephrosclerosis progression after kidney resection consist in the gradual replacement of the all renal cortical and medullar parenchyma by the connective tissue. This is not associated with the autoimmune process, but is more likely due to both impaired urine outflow after intercut of the tubular structures at resection and/or compression by edema, inflammatory infiltrate, forming or organizing scar, and vascular disorders associated with these causes. The inflammation accompanying necrosis and sclerosis of the renal structures can become granulomatous.

Keywords: kidney, kidney resection, cystic change of the kidney tubules, renal scar, nephrosclerosis, granulomatous inflammation
p. 275-284 of the original issue
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Address for correspondence:
630090, Russian Federation,
Novosibirsk, Akad. Lavrentyev Aven., 8,
Institute of Chemical Biology and Fundamental Medicine of the Russian Academy of Sciences, Center of New Medical Technologies,
tel. mob. +7-913-753-0767
Maiborodin Igor V.
Information about the authors:
Maiborodin Igor V., MD, Professor, Chief Researcher of the Laboratory of Health Management Technologies, the Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, the Russian Academy of Sciences, Novosibirsk, Russian Federation.
Marchukov Sergey V., Ph.D, Doctoral Student of the Laboratory of Health Management Technologies, the Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, the Russian Academy of Sciences, Novosibirsk, Russian Federation.
Maiborodina Vitalina I., MD, Leading Researcher of the Laboratory of Ultrastructural Bases of Pathology, Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russian Federation
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