Novosti
Khirurgii
This journal is
indexed in Scopus









Year 2021 Vol. 29 No 2

REVIEWS

DOI: https://dx.doi.org/10.18484/2305-0047.2021.2.234   |  

E.V. BOYKO 1, R.M. TILLYASHAYKHOVA 2, SH.T. KHASANOV 1

SURGICAL MANAGEMENT OF RECURRENCES OF RENAL CELL CARCINOMA

Republican Specialized Scientific Practical Medical Center of Oncology and Radiology 1,
Tashkent City Branch of the Republican Specialized Scientific Practical Medical Center of Oncology and Radiology 2, Tashkent,
The Republic of Uzbekistan

In recent decades the detection of new cases of renal cell carcinoma (RCC) has remained unchanged. This tumor accounts for 2-3% of all cancer diagnoses in humans. Standard methods of surgical treatment are being improved towards less invasive resection methods; this lets achieving the outcomes comparable to traditional nephrectomy in oncological practice. In some cases the risk factor of developing locoregional recurrence still remains after surgical treatment for renal cancer. The limited role of systemic therapy and radioresistance sets hopes on surgical removal of the recurrent tumor. Unfavorable prognostic factors such as the volum of recurrence, the presence of sarcomatoid histological elements, an increased level of serum alkaline phosphatase and lactate dehydrogenase were identified in the materials of several recent studies. The time of recurrence appearance and a forehand surgeries should be defined as one of the independent predictors as it reported by other several studies. The open laparotomic, laparoscopic and robotic methods of tumor removal, as well as the extents of renal segments of repeated resection are discussed depending on the size of the recurrent tumor and the extent of the previous opetations. At the present stage of the development of minimally invasive surgery, with its problem-solving abilities which are very essential in treating the relapsed high-risk patients.

Keywords: renal cell carcinoma, kidney cancer, recurrence of renal cell carcinoma, renal cell carcinoma surgery, nephrectomy, segmental kidney resection
p. 234-241 of the original issue
References
  1. Speed JM, Trinh QD, Choueiri TK, Sun M. Recurrence in Localized Renal Cell Carcinoma: a Systematic Review of Contemporary Data. Curr Urol Rep. 2017 Feb;18(2):15. doi: 10.1007/s11934-017-0661-3
  2. Sun M, Choueiri TK. Kidney cancer: Recurrence in renal cell carcinoma: the work is not done. Nat Rev Urol. 2016 May;13(5):246-47. doi: 10.1038/nrurol.2016.57
  3. Klatte T, Rossi SH, Stewart GD. Prognostic factors and prognostic models for renal cell carcinoma: a literature review. World J Urol. 2018 Dec;36(12):1943-52. doi: 10.1007/s00345-018-2309-4
  4. Bertolo R, Nicolas M, Garisto J, Magi-Galluzzi C, McKenney JK, Kaouk J. Low Rate of Cancer Events After Partial Nephrectomy for Renal Cell Carcinoma: Clinicopathologic Analysis of 1994 Cases with Emphasis on Definition of Recurrence. Clin Genitourin Cancer. 2019 Jun;17(3):209-15.e1. doi: 10.1016/j.clgc.2019.03.004
  5. Kinnear N, Wreghitt S, Hennessey DB, Liodakis P. Rapid development and recurrence of translocation renal cell carcinoma. BMJ Case Rep. 2017;2017:bcr2017219820. Published online 2017 Jun 13. doi: 10.1136/bcr-2017-219820
  6. Bamias A, Escudier B, Sternberg CN, Zagouri F, Dellis A, Djavan B, Tzannis K, Kontovinis L, Stravodimos K, Papatsoris A, Mitropoulos D, Deliveliotis C, Dimopoulos MA, Constantinides CA. Current clinical practice guidelines for the treatment of renal cell carcinoma: a systematic review and critical evaluation. Oncologist. 2017 Jun;22(6):667-79. doi: 10.1634/theoncologist.2016-0435
  7. Ali O, Fishman EK, Kawamoto S. Recurrent renal cell carcinoma following nephrectomy and ablation therapy: Radiology perspective. Eur J Radiol. 2018 Oct;107:134-42. doi: 10.1016/j.ejrad.2018.05.002
  8. Itano NB, Blute ML, Spotts B, Zincke H. Outcome of isolated renal cell carcinoma fossa recurrence after nephrectomy. J Urol. 2000 Aug;164(2):322-25. doi: 10.1016/S0022-5347(05)67350-8
  9. Kobayashi K, Saito T, Kitamura Y, Bilim V, Toba T, Kawasaki T, Hara N, Tanikawa T, Tomita Y. Clinicopathological features and outcomes in patients with late recurrence of renal cell carcinoma after radical surgery. Int J Urol. 2016 Feb;23(2):132-37. doi: 10.1111/iju.12996
  10. Lee Z, Jegede OA, Haas NB, Pins MR, Messing EM, Manola J, Wood CG, Kane CJ, Jewett MAS, Flaherty KT, Dutcher JP, DiPaola RS, Uzzo RG. Local recurrence following resection of intermediate-high risk nonmetastatic renal cell carcinoma: an anatomical classification and analysis of the ASSURE (ECOG-ACRIN E2805) Adjuvant Trial. J Urol. 2020 Apr;203(4):684-89. doi: 10.1097/JU.0000000000000588
  11. Margulis V, Hakimi AA. Cytoreductive nephrectomy: future directions. Curr Opin Urol. 2019 Sep;29(5):540-41. doi: 10.1097/MOU.0000000000000662
  12. Paparel P, Bigot P, Matillon X, Bensalah K, Salomon L, Baumert H, Bastide C, Thuret R, Karsenty G, Long JA, Ammi M, Bessede T, Bin S, Roux A, Escudier B, Rioux Leclercq N, Pignot G, Soulie M, Patard JJ. Local recurrence after radical nephrectomy for kidney cancer: management and prediction of outcomes. a multi-institutional study. J Surg Oncol. 2014 Feb;109(2):126-31. doi: 10.1002/jso.23473
  13. Russell CM, Lebastchi AH, Chipollini J, Niemann A, Mehra R, Morgan TM, Miller DC, Palapattu GS, Hafez KS, Sexton WJ, Spiess PE, Weizer AZ. Multi-institutional Survival Analysis of Incidental Pathologic T3a Upstaging in Clinical T1 Renal Cell Carcinoma Following Partial Nephrectomy. Urology. 2018 Jul;117:95-100. doi: 10.1016/j.urology.2018.04.002
  14. Thomas AZ, Adibi M, Borregales LD, Hoang LN, Tamboli P, Jonasch E, Tannir NM, Matin SF, Wood CG, Karam JA. Surgical management of local retroperitoneal recurrence of renal cell carcinoma after radical nephrectomy. J Urol. 2015 Aug;194(2):316-22. doi: 10.1016/j.juro.2015.02.2943
  15. Thomas AZ, Adibi M, Slack RS, Borregales LD, Merrill MM, Tamboli P, Sircar K, Jonasch E, Tannir NM, Matin SF, Wood CG, Karam JA. The role of metastasectomy in patients with renal cell carcinoma with sarcomatoid dedifferentiation: a matched controlled analysis. J Urol. 2016 Sep;196(3):678-84. doi: 10.1016/j.juro.2016.03.144
  16. Shapiro DD, Wells SA, Best SL, Hedican SP, Ziemlewicz TJ, Lubner MG, Hinshaw JL, Lee FT Jr, Jarrard DF, Richards KA, Downs TM, Allen GO, Nakada SY, Abel EJ. Comparing outcomes for patients with clinical t1b renal cell carcinoma treated with either percutaneous microwave ablation or surgery. Urology. 2020 Jan;135:88-94. doi: 10.1016/j.urology.2019.09.024
  17. Harbin AC, Bandi G, Vora AA, Cheng X, Stanford V, McGeagh K, Murdock J, Ghasemian R, Lynch J, Bedell F, Verghese M, Hwang JJ. Does pure robotic partial nephrectomy provide similar perioperative outcomes when compared to the combined laparoscopic-robotic approach? J Robot Surg. 2014 Mar;8(1):23-27. doi: 10.1007/s11701-013-0414-3
  18. Yohannan J, Feng T, Berkowitz J, Connolly SS, Pierorazio P, Allaf ME. Laparoscopic resection of local recurrence after previous radical nephrectomy for clinically localized renal-cell carcinoma: perioperative outcomes and initial observations. J Endourol. 2010 Oct;24(10):1609-12. doi: 10.1089/end.2010.0051
  19. El Hajj A, Thanigasalam R, Molinié V, Massoud W, Fourati M, Girard F, Escudier B, Baumert H. Feasibility and oncological outcomes of laparoscopic treatment for local relapse of renal cell carcinoma. BJU Int. 2013 Aug;112(4):E307-13. doi: 10.1111/j.1464-410X.2012.11724.x
  20. Woldu SL, Matulay JT, Clinton TN, Singla N, Freifeld Y, Sanli O, Krabbe LM, Hutchinson RC, Lotan Y, Hammers H, Hannan R, Brugarolas J, Bagrodia A, Margulis V. Incidence and outcomes of delayed targeted therapy after cytoreductive nephrectomy for metastatic renal-cell carcinoma: a nationwide cancer registry study. Clin Genitourin Cancer. 2018 Dec;16(6):e1221-e35. doi: 10.1016/j.clgc.2018.08.001
  21. Gilbert D, Abaza R. Robotic excision of recurrent renal cell carcinomas with laparoscopic ultrasound assistance. Urology. 2015 May;85(5):1206-10. doi: 10.1016/j.urology.2015.01.036
  22. Huang JW, Cai W, Kong W, Zhang J, Chen YH, Huang YR. Surgical management for local retroperitoneal recurrence of 33 renal cell carcinoma patients underwent radical nephrectomy. Zhonghua Zhong Liu Za Zhi. 2019 Sep 23;41(9):703-707. doi: 10.3760/cma.j.issn.0253-3766.2019.09.011
  23. Armas-Alvarez AL, Alois Osorio-Manyari A, Donate-Moreno MJ, Vera-Beron R, Salinas-Sänchez AS. Local and distant recurrence of the chromophobe renal cell carcinoma. Arch Esp Urol. 2020 Jan;73(1):71-75. https://dialnet.unirioja.es/servlet/articulo?codigo=7207684
  24. Rolley C, Aubert C, Baize N, Bigot P. Management of metastatic renal cell carcinomass. Prog Urol. 2018 Nov;28(14):777-82. doi: 10.1016/j.purol.2018.07.280
  25. Siebenthall KT, Miller CP, Vierstra JD, Mathieu J, Tretiakova M, Reynolds A, Sandstrom R, Rynes E, Haugen E, Johnson A, Nelson J, Bates D, Diegel M, Dunn D, Frerker M, Buckley M, Kaul R, Zheng Y, Himmelfarb J, Ruohola-Baker H, Akilesh S. Integrated epigenomic profiling reveals endogenous retrovirus reactivation in renal cell carcinoma. EBioMedicine. 2019 Mar;41:427-42. doi: 10.1016/j.ebiom.2019.01.063
  26. Baiocco JA, Ball MW, Pappajohn AK, Rayn KN, Bratslavsky G, Boyle SL, Linehan WM, Metwalli AR. A comparison of outcomes for standard and multiplex partial nephrectomy in a solitary kidney: The National Cancer Institute experience. Urol Oncol. 2019 Jun;37(6):356.e1-56.e7. doi: 10.1016/j.urolonc.2019.02.015
  27. Kriegmair MC, Bertolo R, Karakiewicz PI, Leibovich BC, Ljungberg B, Mir MC, Ouzaid I, Salagierski M, Staehler M, van Poppel H, Wood CC, Capitanio U; Young Academic Urologists Kidney Cancer working group of the European Association of Urology. Systematic Review of the Management of Local Kidney Cancer Relapse. Eur Urol Oncol. 2018 Dec;1(6):512523. doi: 10.1016/j.euo.2018.06.007
  28. Acar Ö, Şanlı Ö. Surgical management of local recurrences of renal cell carcinoma. Surg Res Pract. 2016;2016:2394942. doi: 10.1155/2016/2394942
Address for correspondence:
Republic of Uzbekistan, Tashkent,
Farobiy Street, 383,
Republican Specialized Scientific Practical Medical Center of Oncology and Radiology,
the Urological Department,
tel. +998 90 120-09-30,
e-mail: joker789987@mail.ru,
Boyko Elena V.
Information about the authors:
Boyko Elena V., PhD, Research Manager of the Urologic Department, Republican Specialized Scientific Practical Medical Center of Oncology and Radiology, Tashkent, Republic of Uzbekistan.
https://orcid.org/0000-0001-7266-5704
Tillyashaykhova Rano M.,PhD, Physician of the Urologic Department, Tashkent City Branch of the Republican Specialized Scientific Practical Medical Center of Oncology and Radiology, Tashkent, Republic of Uzbekistan.
https://orcid.org/0000-0003-3559-4913
Khasanov Sherali T., Head of the Urologic Department, Republican Specialized Scientific Practical Medical Center of Oncology and Radiology, Tashkent, Republic of Uzbekistan.
https://orcid.org/0000-0002-0607-4014
Contacts | ©Vitebsk State Medical University, 2007