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Khirurgii

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Year 2020 Vol. 28 No 2

TRANSPLANTOLOGY

A.O. NYKONENKO 1,2, O.S. NYKONENKO 1, D.A. BUGA 2, I.V. RUSANOV 2, S.R.VILDANOV 1

HEALTH STATUS ASSESSMENT OF RELATED KIDNEY DONORS IN THE LATE POSTOPERATIVE PERIOD

Zaporizhzhya State Medical University 1,
Zaporizhzhya Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine 2, Zaporizhia,
Ukraine

Objective. To analyze the health status of living kidney donors based on the degree of restoration of the kidney function and the general physical status of the donor.
Methods. 37 related kidney donors underwent nephrectomy between 2014 and 2017. The average age was 48.3±9.7 (̱σ) years, with 19 men (51%) and 18 (49%) women. In the late postoperative period (1,9±1,1 years (̱σ)), the levels of proteinuria, and glomerular filtration rate (GFR) were studied. The life quality of kidney donors was assessed using the Medical Outcomes Study-Short Form-36 questionnaire.
Results. The average GFR before the operation was 78,9±24,5 ml/min per 1.73 m2, and fell to 49,8±11,2 ml/min per 1.73 m2 on the 2nd day after the operation. Upon discharge (15,2±7,0 day), average GFR increased to 53,4±8,0 ml/min per 1.73 m2, and almost reached pre-operation levels 1,9±1,1 years after the operation. This suggests that a single normally-functioning kidney is capable of taking on the load from the missing kidney. Furthermore, our study showed that, in the late postoperative period, there was no statistically significant difference in either GFR or quality of life between the donors of different age groups (p>0.05). Our research showed that if adequate protocols are used for living donor selection, donor-recipient kidney transplantation is not only an effective method for treating terminal stage of chronic end stage of renal disease, but is also safe for health and the subsequent renal function of the donor.
Conclusions. In living donors, a gradual restoration of renal function is observed, according to GFR, at discharge (day 15.2±7.0) and in the late postoperative period (1.9±1.1 years), almost reaching the preoperative level. The physical and psychological health components of donors of different age groups were comparable.

Keywords: transplantation, living kidney donor, donor nephrectomy, postoperative period, renal failure
p. 173-179 of the original issue
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Address for correspondence:
69035, Ukraine,
Zaporizhia, pr. Mayakovskii, 26,
Zaporizhzhya State Medical University,
the hospital surgery chair,
tel. +38 (097)-594-54-93,
e-mail: nikonandra@gmail.com,
Nykonenko Andriy A.
Information about the authors:
Nykonenko Andriy O., Doctor of Medical Sciences (MD), Professor, Head of the Hospital Surgery Chair, Zaporizhzhya State Medical University, Zaporizhia, Ukraine.
https://orcid.org/0000-0002-5720-2602
Nykonenko Olexandr S., Doctor of Medical Sciences (MD), Professor, Academician of NAMS of Ukraine, Corresponding Member of NAS of Ukraine, Rector, Zaporizhzhya Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine , Zaporizhia, Ukraine.
https://orcid.org/0000-0001-7333-4165
Buga Dmitrii A., MD, Associate Professor, Head of the Department of Transplantology and Endocrine Surgery with the Courses of the Cardiovascular Surgery, Zaporizhzhya Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine, Zaporizhia, Ukraine.
https://orcid.org/0000-0001-5818-3100
Rusanov Ihor V., Candidate of Medical Sciences (PhD), Associate Professor of the Department of Transplantology and Endocrine Surgery with the Courses of the Cardiovascular Surgery, Zaporizhzhya Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine, Zaporizhia, Ukraine.
https://orcid.org/0000-0002-4363-1158
Vildanov Serhii R., Candidate of Medical Sciences (PhD), Assistant of the Hospital Surgery Department, Zaporizhzhya State Medical University, Zaporizhia, Ukraine.
https://orcid.org/0000-0003-3885-9390
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