Novosti
Khirurgii
This journal is
indexed in Scopus









Year 2019 Vol. 27 No 4

GENERAL & SPECIAL SURGERY

DOI: https://dx.doi.org/10.18484/2305-0047.2019.4.379   |  

E.A. ILICHEVA 1,3, D.A. BULGATOV 1,2,3, A.V. ZHARKAYA 1,3, V.N. MAKHUTOV 3, L.B. KORYAKINA 1,3, S.V. RYZHIKOVA 3, A.N. ZAGORODNYAYA 3, T.V. IVANOVA 3

EVALUATION OF FGF23 LEVEL BEFORE AND AFTER SURGICAL TREATMENT OF SECONDARY HYPERPARATHYREOSIS

Irkutsk Scientific Center of Surgery and Traumatology 1,
Irkutsk State Medical University 2,
Irkutsk Regional Clinical Hospital 3, Irkutsk,
The Russian Federation

Objective. To study the level of FGF23 before and after thesecondary hyperparathyroidism surgical treatment and in the comparison groups in patients receiving hemodialysis divided by the level of parathyroid hormone and in healthy people.
Methods. The level of FGF23; pg/ml in the blood was simultaneouslystudied before and after surgical treatment for secondary hyperparathyroidism in patients undergoing renal replacement therapy. In the comparison groups, the level of FGF23 in the blood was studied in patients receiving dialysis for the terminal stage of chronic kidney disease (CKD). The groups were divided according to the level of intact parathyroid hormone (PTH) in the blood: with hypoparathyroidism (PTH less than 130 pg/ml), with an acceptable level of PTH (130-600 pg/ml), and hyperparathyroidism (PTH more than 600 pg/ml). The level of FGF23 in healthy individuals was also studied. A total of 77 people were examined (33 females and 44 males). To assess the mineral-bone disorders, the standard laboratory examination was performed: a biochemical blood test with electrolytes (albumen, total calcium with albumin correction, phosphorus), PTH in blood.
Results. Data have been obtained that the level of FGF23 in the group of healthy individuals is statistically lower than in the other groups (pU = 0.001). Between groups of people with terminal stage of CKD, the difference in FGF23 is not statistically significant (pU > 0.05).
Conclusions. All patients receiving dialysis, regardless of the severity of secondary hyperparathyroidism before and after surgical treatment, have an increased level of FGF23 in comparison with healthy people. Statistically significant differences in level of FGF23 depending on the presence or absence of secondary hyperparathyroidism and the result of surgical treatment of SHPT were not detected. According to the data obtained, further research is needed to identify the role of FGF23 in the pathogenesis of secondary hyperparathyroidism.

Keywords: secondary hyperparathyroidism, chronic kidney disease, phosphatonin, fibroblast growth factor 23, FGF23, mineral and bone disorders
p. 379-385 of the original issue
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Address for correspondence:
664003, The Russian Federation,
Irkutsk, Krasnoye Vosstaniye Str., 1,
Irkutsk State Medical University,
Hospital Surgery Department.
Tel. 8 (3952) 407809,
-mail: bbd-x@mail.ru,
Dmitriy A. Bulgatov
Information about the authors:
Ilicheva Elena A., MD, Professor, Head of the Scientific Department of Clinical Surgery, Irkutsk Scientific Center of Surgery and Traumatology, Surgeon of the Thoracic Surgical Unit, Irkutsk Regional Clinical Hospital, Irkutsk, Russian Federation.
https://orcid.org/0000-0002-2081-8665
Bulgatov Dmitriy A., Intramural Post-Graduate Student of the Hospital Surgery Department, Irkutsk State Medical University, Surgeon of the Purulent Surgery Unit 1, Irkutsk Scientific Center of Surgery and Traumatology, Surgeon of the Thoracic Surgical Unit, Irkutsk Regional Clinical Hospital, Irkutsk, Russian Federation.
https://orcid.org/0000-0002-2440-0813
Zharkaya Anastasia V., PhD, Junior Researcher, Irkutsk Scientific Center of Surgeryand Traumatology, Surgeon of the Endocrinology Center, Irkutsk Regional Clinical Hospital, Irkutsk, Russian Federation.
https://orcid.org/0000-0002-9337-2369
Makhutov Valerij N., PhD, Head of the Thoracic Surgical Unit, Irkutsk Regional Clinical Hospital, Irkutsk, Russian Federation.
https://orcid.org/0000-0001-7318-7193
Koryakina Larisa B., PhD, Head of the Center of the Laboratory Investigations, Irkutsk Regional Clinical Hospital, Irkutsk, Russian Federation.
https://orcid.org/0000-0002-4545-2049
Ryzhikova Svetlana V., Physician of the Center of the Laboratory Investigations, Irkutsk Regional Clinical Hospital, Irkutsk, Russian Federation.
https://orcid.org/0000-0003-3070-7720
Ivanova Tatiana V., Physician of the Center of the Laboratory Investigations, Irkutsk Regional Clinical Hospital, Irkutsk, Russian Federation.
https://orcid.org/0000-0002-9277-1587
Zagorodnyaya Anna N., Physician of the Center of the Laboratory Investigations, Irkutsk Regional Clinical Hospital, Irkutsk, Russian Federation.
https://orcid.org/0000-0003-0685-2426
Contacts | ©Vitebsk State Medical University, 2007