Novosti
Khirurgii

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Year 2018 Vol. 26 No 4

REVIEWS

YU.S. LOBANOV, S.L. LOBANOV, K.G. SHAPOVALOV

CHANGES IN MICROCIRCULATION DUE TO INTRA-ABDOMINAL HYPERTENSION IN SURGERY

Chita State Medical Academy, Chita,
The Russian Federation

The introduction of modern surgical technologies is often accompanied by negative effects. The use of endoscopic techniques can lead to the development of the phenomenon of intra-abdominal hypertension, which is also found in many pathological processes in the abdominal cavity. One of serious complications is hemodynamic disorder, hemostasis system disorders leading to thrombosis and thromboembolism. Long-term hypertension is accompanied by the development of the abdominal compartment syndrome with the development of multiple organ failure. It is important to prevent complications.
This review presents current data on the disorders in the microcirculation system arising when intra-abdominal pressure increases. Pathophysiological reactions in the hemostatic system are studied. The study of the influence of intraperitoneal hypertension, created as a result of pneumoperitoneum, on coagulation and fibrinolysis under general anesthesia, revealed negative changes in the postoperative period, which led to activation of clotting factors and inhibition of fibrinolysis. Studies of the endothelial function in case of intra-abdominal hypertension are presented. Possible markers with the help of which it is possible to predict pathological reactions are considered.
The conducted literature review shows that shifts of hemocoagulation in patients with calculous cholecystitis can contribute to the development of venous thromboembolism. The root cause of endothelial dysfunction can also be a regional disturbance of microcirculation.

Keywords: intra-abdominal hypertension, hemostasis, endothelium, microcirculation, venous thromboembolism
p. 465-472 of the original issue
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Address for correspondence:
672000, The Russian Federation,
Chita, Gorky Str., 39A,
Chita State Medical Academy,
Department of Faculty Surgery
With the Course of Urology,
Tel.: +7(3022)35-43-24,
e-mail: slobanov15@mail.ru,
Sergey L. Lobanov
Information about the authors:
Lobanov Yuriy S., PhD, Assistant of the Department of Faculty Surgery with the Course of Urology, Chita State Medical Academy, Chita, Russian Federation.
http://orcid.org/0000-0002-9398-1447
Lobanov Sergey L., MD, Professor, Head of the Department of Faculty Surgery with the Course of Urology, Chita State Medical Academy, Chita, Russian Federation.
http://orcid.org/0000-0003-1665-3754
Shapovalov Konstantin G., MD, Professor, Head of the Department of Anesthesiology and Resuscitation, Chita State Medical Academy, Chita, Russian Federation.
http://orcid.org/0000-0002-3485-5176
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