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Khirurgii

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Year 2016 Vol. 24 No 4

GENERAL & SPECIAL SURGERY

V.I. RUSIN, E.S. SIRCHAK, S.S. FILIP, P.F. SERVETNIK

THE ROLE OF α1-ANTITRYPSIN IN THE ETIOLOGY OF CHRONIC PANCREATITIS AND ITS COMPLICATIONS

SHEE "Uzhgorod National University",
Uzhgorod
Ukraine

Objectives. To investigate the dynamics of α1-antitrypsin (α1-AT) indices in the blood and feces of patients with complicated forms of chronic pancreatitis (CP).
Methods. The patients (n=158) with the pseudocystic forms chronic pancreatitis (PCP) were examined. They were distributed into 2 groups: group I (n=76) – the patients with pancreatic pseudocysts without CP complications; group II (n=82) – patients with CP, in whom was complicated with the pre-liver portal hypertension (PH), infectioning of the PCP, hemorrhage from the upper parts of the digestive tract, duodenal obstruction and obstructive jaundice. The levels of α1-AT (“Immundiagnostic AG”, Germany) were determined in the blood serum and feces of patients and its clearance were calculated. The study was conducted before treatment and on the 5th day after the surgery.
Results. In patients of group I the indices of α1-AT in the blood plasma were slightly higher than the indices of the control group, but the level in the feces and its clearance did not differ from those in healthy people. In patients of group II the overall level of α1-AT in the blood plasma was 6,6 fold higher than the indices of the control group. High concentration of α1-AT in the blood in the given patients before treatment was accompanied by its increased level in feces as well as its fecal clearance.
Conclusion. In patients with complicated forms of PCP pancreatitis an increase of α1-AT level in the blood plasma and feces is observed as well as its fecal clearance. The highest indices of α1-AT in the blood plasma and feces are determined in infecting of PCP, pre-liver PH and duodenal obstruction in patients with CP. Surgical interventions on the pancreas lead to reduction of α1-AT level in the blood plasma and feces as well as its fecal clearance.

Keywords: chronic pancreatitis, pancreas, α1-antitrypsin, blood plasma, duodenal obstruction, surgical intervention, fecal clearance
p. 355-360 of the original issue
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Address for correspondence:
88000, Ukraine, Transcarpathian region, Uzhgorod, People sq., 1, SHEE "Uzhhorod National University", faculty of medicine, chair of propedeutics of internal deseases. Tel: + 38050-976-17-94
E-mail: szircsak_heni@bigmir.net
Sirchak Elizaveta Stepanovna
Information about the authors:
Rusin V.I. MD, Professor, SHEE "Uzhgorod National University", chair of surgical diseases, medical faculty.
Sirchak E.S. MD, Professor, SHEE "Uzhgorod National University", chair of propaedeutics of internal diseases, medical faculty.
Filip S.S. MD, Professor, SHEE "Uzhgorod National University", chair of general surgery, medical faculty.
Servetnik P.F. Post-graduate student, SHEE "Uzhgorod National University", chair of general surgery , medical faculty.
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