Year 2015 Vol. 23 No 2

SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY

B.S. SUKOVATYKH, A.Y. GRIGORYAN, A.I. BEZHIN, T.A.P ANKRUSHEVA, S.A. ABRAMOVA

EFFECTIVENESS OF IMMOBILIZED FORM OF CHLORHEXIDINE IN TREATMENT OF PURULENT WOUNDS

SBEE HPE "Kursk State Medical University"
The Russian Federation

Objectives. To justify experimentally the possibility of chlorhexidine bigluconate immobilized form application in the treatment of the first phase of purulent wounds course.
Methods. The analysis of the results of experimental studies of wound healing process (120 Wistar rats) has been carried out in the treatment of the following ointment composition: chlorhexidine bigluconate 0,5% 30,0; methyluracil 2,0; polymethylsiloxane polyhydrate 70,0.
Animals were divided into two statistically homogeneous groups of 60 animals each. In the control group the local wound treatment was carried out by application of Levomecol ointment, while in the experimental one an immobilized form of chlorhexidine bigluconate. The dynamics of the wound healing process was studied by means of planimetric, bacteriological and histological methods.
Results. In the main group the reduction percentage of the wound area was higher than in the control group on the 3rd day by 14,2%, on the 5th day 9,1%, on the 10th day 12,8%, on the 15th day 11,1%.
In the experimental group of animals the microbial contamination of wounds (CFU in 1 g. of tissue) was lower in the control group on the 3rd day of treatment on 7×106, on the 5th day on 4,3×105, on the 8th day on 6,2×104, and on the 10th day on 62,5×103. At the same period the number of fibroblasts (cells of reparative series) in the wounds of the main group was higher on 0,5%, 10,6%, 12,1% and 9,4%.
Conclusion. The use of an immobilized form of chlorhexidine bigluconate in the treatment of the first phase of purulent wounds is considered to be pathogenetically justified and effective.

Keywords: purulent wound, wound process, research methods, wound healing, wound treatment, ointment "Levomecol", immobilized form of hlorhexidine bigluconate
p. 138-144 of the original issue
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Address for correspondence:
305041, Rossiyskaya Federatsiya,
g. Kursk, ul. K. Marksa d. 3,
GBOU VPO "Kurskiy gosudarstvennyiy meditsinskiy universitet",
kafedra obschey khirurgii,
tel.office : 7 (4712) 52-98-62,
e-mail: SukovatykhBS@kursksmu.net,
Sukovatykh Boris Semenovich
Information about the authors:
Sukovatykh B.S. MD, professor, a head of the general surgery chair of SBEE HPE "Kursk State Medical University".
Grigoryan A.Y. PhD, an assistant of the operative surgery and topographic anatomy chair of SBEE HPE "Kursk State Medical University".
Bezhin A.I. MD, professor, a head of the operative surgery and topographic anatomy chair of SBEE HPE "Kursk State Medical University".
Pankrusheva T.A. MD, professor, a head of the pharmaceutical technologies chair of SBEE HPE "Kursk State Medical University".
Abramova S.A. PhD, an assistant of the surgical diseases chair 2 of SBEE HPE "Kursk State Medical University".
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