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Khirurgii

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Year 2013 Vol. 21 No 4

REVIEWS

D.B. BORISOV 1, M.Y. KIROV 2

THE USE OF TRANEXAMIC ACID IN MAJOR JOINT REPLACEMENT

Northern Medical Clinical Centre named N. A. Semashko 1,
Northern State Medical University 2,
Arkhangelsk,
Russian Federation

The literature review of researches devoted to the use of fibrinolysis inhibitors to reduce perioperative blood loss, particularly tranexamic acid in endoprothesis of large joints is presented in this paper. Analysis of the literature showed that sufficient number of evidences of tranexamic acid effectiveness in reducing of blood loss and the frequency of allogeneic blood transfusion in orthopedics is received. There is currently no information about the increase of the number of postoperative complications in tranexamic acid application in planned surgery. To determine the optimal regime of systemic administration of tranexamic acid the further research is needed. Intra-articular injection of the tranexamic acid in endoprothesis of joints effectively reduced the postoperative blood loss. Compared to intravenous administration the local intra-articular administration of the tranexamic acid seems to be more safe and effective in blood loss reduction. Major prospective studies are required to confirm this assumption.

Keywords: tranexamic acid, blood loss, joint replacement
p. 107 – 112 of the original issue
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Address for correspondence:
163000, Rossiiskaia Federatsiia, g. Arkhangel'sk, pr. Troitskii, d. 115, FGBUZ «Severnyi meditsinskii klinicheskii tsentr imeni N.A. Semashko», otdelenie anesteziologii, reanimatsii i intensivnoi terapii,
e-mail: bor_d@mail.ru,
Borisov Dmitrii Borisovich
Information about the authors:
Borisov D.B. PhD, a head of anesthesiology, resuscitation and intensive therapy unit of FSBEE “Northern medical clinical centre named after N.A. Semashko”.
Kirov M.Y. MD, professor, a head of anesthesiology and resuscitation chair of SBEE HPE “Northern State Medical University”.
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