Novosti
Khirurgii

 This journal is
indexed in Scopus
journal cover
android icon Android Applicaion

Year 2011 Vol. 19 No 6

EXPERIMENTAL SURGERY

V.А. КOSINETS, I.V. SAMSONOVA, E.L. RYZHKOVSKAYA IN THE LIVER AT THE EXPERIMENTAL WIDESPREAD

STRUCTURAL CHANGES IN THE LIVER AT THE EXPERIMENTAL WIDESPREAD PURULENT PERITONITIS

Objectives. To study structural changes in the liver using light and electronic microscopy and the ways of its correction at an experimental widespread purulent peritonitis.
Methods. The structural changes in the liver using light and electronic microscopy were studied during the experiment on 55 male rabbits of chinchilla breed at the experimental widespread purulent peritonitis.
Results. In 6 hours after initiation of peritonitis in the liver the hemodynamic disorders, interstitional edema, severe inflammatory neutrophilic parenchyma infiltration were observed. In the majority of hepatocytes dystrophic, necrobiotic and necrotic changes were defined. Intensive mitochondrial destruction testified to the deficiency of the hepatocytes power maintenance.
Conclusions. The comparative analysis of action of metabolic preparations "Citoflavin" which contains amber acid and "Neoton" containing phosphocreatine on a structural condition of the liver at the experimental widespread purulent peritonitis has revealed high efficiency of the preparation "Citoflavin". The last one provided intensive restoration of the liver structure, decrease of inflammatory changes and preservation of integrity of mitochondrions.

Keywords: widespread purulent peritonitis, heart, structural changes, mitochondria, «Neoton», «Citoflavin»s
p. 8 – 14 of the original issue
References
  1. Aronsohn, A. Hepatobiliary manifestations of critically ill and postoperative patients / A. Aronsohn, D. Jensen // Clin. Liver. Dis. – 2011. – Vol. 15. – P. 183-197.
  2. Han, D. W. Intestinal endotoxemia as a pathogenetic mechanism in liver failure / D. W. Han // World J. Gastroenterol. – 2002. – Vol. 8. – P. 961-965.
  3. Singh, R. Autophagy and regulation of lipid metabolism / R. Singh // Results Probl. Cell Differ. – 2010. – Vol.52. – P. 35-46.
  4. Wynn, T. A. Macrophages: master regulators of inflammation and fibrosis / T. A. Wynn, L. Barron // Liver Dis. – 2010. – Vol. 30. – P. 245-257.
  5. Studies of the route, magnitude, and time course of bacterial translocation in a model of systemic inflammation / M. R. Mainous [et al.] // Arch. Surg. – 1991. – Vol. 126. – P. 33-37.
  6. Katz, S. Liver bacterial clearance following hepatic artery ligation and portacaval shunt / S. Katz // J. Surg. Res. – 1991. – Vol. 51. – P. 267-270.
  7. Circulating interleukin 6 during a continuous infusion of tumor necrosis factor and interferon gamma / P. Brouckaert [et al.] // J. Exp. Med. – 1989. – Vol. 169. – P. 2257-2262.
  8. Hart, P. H. IL-4 suppresses IL-1b, TNF-a and PGE2 production by human peritoneal macrophages / P. H. Hart, R. L. Cooper, J. J. Finlay-Jones // Immunology. – 1991. – Vol. 72. – P. 344-349.
  9. Vary, T. C. Regulation of hepatic protein synthesis in chronic inflammation and sepsis / T. C. Vary, S. C. Kimball // Am. J. Physiol. – 1992. – Vol. 262. – P. C445-C452.
  10. Feder, L. S. Chararcterization of interleukin-1 and interleukin-6 production by hepatic endothelial cells and macrophages / L. S. Feder, J. A. Todaro, D. L. Laskin // J. Leukoc. Biol. – 1993. – Vol. 53. – P. 126-132.
  11. Spitzer, J. A. Cytokine stimulation of nitric oxide formation and differential regulation in hepatocytes and nonparenchymal cells of endotoxemic rats / J. A. Spitzer // Hepatology. – 1994. – Vol. 19. – P. 217-228.
  12. Илюкевич, Г. В. Особенности нарушений метаболизма липидов и возможность их коррекции у больных с распространенным перитонитом / Г. В. Илюкевич, И. И. Канус, Г. Я. Хулуп // Вестн. интенсив. терапии. – 2002. – № 3. – С. 83-87.
  13. Huet, O. Oxidative stress and endothelial dysfunction during sepsis / O. Huet // Front Biosci. – 2011. – Vol. 16. – P. 1986-1995.
  14. Smets, D. Liver perfusion and hepatocellular inflammatory response in sepsis / D. Smets, H. Spapen, M. Diltoer // Acta. Clin. Belg. – 1999. – Vol. 54. – P. 201-206.
  15. Wang, P. Mechanism of hepatocellular dysfunction during hyperdynamic sepsis / P. Wang, I. H. Chaudry // Am. J. Physiol. – 1996. – Vol. 270. – P. R927-R 938.
  16. Чернов, В. Н. Классификация и принципы лечения острого гнойного перитонита / В. Н. Чернов, Б. М. Велик // Хирургия. – 2002. – № 4. – С. 52-56.
  17. Волкова, О. В. Основы гистологии с гистологической техникой / О. В. Волкова, Ю. К. Елецкий. – М.: Наука, 1982. – 304 с.
  18. Карупу, В. Я. Электронная микроскопия / В. Я. Карупу. – К.: Вища шк., 1984. – 208 с.
Contacts | ©Vitebsk State Medical University, 2007-2023