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Khirurgii

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Ñîãëàñèòüñÿ

Year 2010 Vol. 18 No 5

GENERAL AND SPECIAL SURGERY

DZIDZAVA I.I., KOTIV B.N., KASHKIN D.P., SMORODSKI A.V., SLOBODYANIK A.V.

THE CLEARANCE-TEST WITH INDOCIAN GREEN AS A PROGNOSTIC RISK FACTOR FOR SURVIVING IN PATIENTS WITH CIRRHOSES AND PORTAL HYPERTENSION

Objectives. To study the possibility and informational content of clearance-test with indocian green as a prognostic risk factor for surviving in the patients with cirrhoses and portal hypertension.
Methods. 189 patients with cirrhoses complicated by the portal hypertension syndrome and 30 patients without sings of liver diseases were included in the research.
Results. Plasma of disappearance rate (PDRICG) was reliably lower in the patients with cirrhoses (8,2±4,6%/min and 24,9±4,2%/min, p=0,001) and its retention rate on the 15th minute (RR15) significantly increased (34,1±16,5% and 6,8±2,3%, p=0,001). Highly reliable correlation between parameters of clearance-test and histology activity (r=-0,579, p=0,006) index, levels of bilirubin (r=-0,540, p=0,001) and albumin (r=0,447, p=0,001), protrombine time (r=0,449, p=0,001) and volume flow of the portal vein (r=0,482, p=0,001) was revealed. Indexes of test with indocianin green got worse in progress with increasing of heaviness of hepatocellular dysfunction, concordantly to the score of Child-Pugh and MELD. PDRICG had more prognostic ability if compared with these scales as in predicting one-year or five-year surviving (c- statistic 0,813±0,043 and 0,810±0,041). PDRICG less than 8,0%/min and RR15 more than 30,5%, with sensitivity 95% and specific character 80% were the risk factors for surviving after selective and partial portocaval shunting.
Conclusions. The definition of clearance of indocianin green is high informative and specific dynamical test, allowing to estimate the liver functional reserves and to predict survival rate in patients with cirrhoses.

Keywords: clearance-test, indocian green, liver cirrhoses, portocaval shunting
p. 37 – 48 of the original issue
References
  1. Carithers, J. L. Jr. Liver transplantation. American Association for the study of liver diseases / J. L. Carithers // Liver Transpl. – 2000. – Vol. 6. – P. 122-135.
  2. MELD scoring system is useful for predicting prognosis in patients with liver cirrhosis and is correlated with residual liver function: a European study / F. Botta [et al.] // Gut. – 2003. – Vol. 52. – P. 134-139.
  3. Evaluation of liver functional reserve by combining D-sorbitol clearance rate and CT measured liver volume / Y. M. Li [et al.] // World J. Gastroenterol. – 2003. – Vol. 9. – P. 2092-2095.
  4. Hashimoto, M. Hepatic parenchymal cell volume and the indocyanine green tolerance test / M. Hashimoto, G. Watanabe // J. Surg. Res. – 2000. – Vol. 92. – P. 222-227.
  5. Model for End-Stage Liver Disease (MELD) predicts nontransplant surgical mortality in patients with cirrhosis / P. G. Northup [et al.] // Ann. Surg. – 2005. – Vol. 242. – Ð. 244-251.
  6. Assessment of pretransplant prognosis in patients with cirrhosis / M. Oellerich [et al.] // Transplantation. – 1991. – Vol. 51. – P. 801-806.
  7. Comparison of quantitative methods to assess hepatic function: Pugh’s classification, indocyanine green, antipyrine, and dextromethorphan / W. D. Figg [et al.] // Pharmacotherapy. – 1995. – Vol. 15. – P. 693-700.
  8. Faybik, P. Plasma disappearance rate of indocyanine green in liver dysfunction / P. Faybik, H. Hetz // Transplant. Proc. – 2006. – Vol. .38. – P. 801-802.
  9. 13C-galactose breath test and 13C-aminopyrine breath test for the study of liver function in chronic liver disease / E. G. Giannini [et al.] // Clin. Gastroenterol. Hepatol. – 2005. – Vol. 3. – P. 279-285.
  10. Hepatic phenylalanine metabolism measured by the [13C] phenylalanine breath test / T. Kobayashi [et al.] // Eur. J. Clin. Invest. – 2001. – Vol. 31. – P. 356-361.
  11. The lidocaine (MEGX) test as an index of hepatic function: its clinical usefulness in liver surgery / G. Ercolani [et al.] // Surgery. – 2000. – Vol. 127. – P. 464-471.
  12. Mukherjee, S. Comparison of indocyanine green clearance with Child’s-Pugh score and hepatic histology: a multivariate analysis / S. Mukherjee, M. A. Rogers, B. Buniak // Hepatogastroenterology. – 2006. – Vol. 53. – P. 120-123.
  13. Paquet, K. J. Sclerotherapy for the prevention of bleeding esophageal varices / K. J. Paquet // Internist (Berl.). – 1983. – Vol. 24. – Ð. 81-84.
  14. Gastric lesions in portal hypertension: inflammatory gastritis or congestive gastropathy? / T. T. McCormack [åt al.] // Gut. – 1985. – Vol. 26. – P. 1226-1232.
  15. Ïîäûìîâà, Ñ. Ä. Áîëåçíè ïå÷åíè: ðóêîâîäñòâî / Ñ. Ä. Ïîäûìîâà. – Ì.: ÎÀÎ «Èçä-âî «Ìåäèöèíà», 2005. – 768 ñ.
  16. Formulation and application of numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis / R. G. Knodell [et al.] // Íepatology. – 1981. – Vol. 1. – P. 431-436.
  17. Hyperendothelinemia and ICG clearance in alcoholic and nonalcoholic cirrhosis / S. Maruyama [et al.] // Dig. Dis. Sci. – 2002. – Vol. 47. – P. 773-777.
  18. Intrinsic hepatic clearance and Child-Turcotte classification for assessment of liver function in cirrhosis / J. C. Barbare [et al.] // J. Hepatol. – 1985. – Vol. 1. – P. 253-259.
  19. Adedoyou, A. Pharmacokinetics / A. Adedoyou // Hepatology: a textbook of liver Disease / eds. D. Zakin, T. D. Boyer. – 3rd ed. – Philadelphia: W. B. Saunders, 1996. – P. 311-313.
  20. Indocyanine green intrinsic hepatic clearance as a prognostic index of survival in patients with cirrhosis / C. Merkel [et al.] // J. Hepatol. – 1989. – Vol. 9. – P. 16-22.
  21. Superiority of the Child-Pugh classification to quantitative liver function tests for assessing prognosis of liver cirrhosis / I. Albers [et al.] // Scand. J. Gastroenterol. – 1989. – Vol. 24. – P. 269-276.
  22. Monoethylglucine xylidide test evaluation in primary biliary cirrhosis: comparison with Mayo score / T. Gindro [et al.] // Eur. J. Gasrtoenterol. Hepatol. – 1997. – Vol. 12. – P. 1155-1159.
  23. Can the MEGX test and serum bile acids improve the prognostic ability of Child-Pugh’s score in liver cirrhosis? / R. Testa [et al.] // Eur. J. Gastroenterol. Hepatol. – 1999. – Vol. 11. – P. 559-563.
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