Novosti
Khirurgii
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Year 2009 Vol. 17 No 4

ONCOLOGY

MIKHAILOV I.V., BELYAKOVSKY V.N., LUD A.N., AL-YAHIRI A.K.

LONG-TERM RESULTS OF COMBINED TREATMENT OF LOCALLY ADVANCED RESECTABLE GASTRIC CANCER STAGE IV (T4N1-3M0) WITH POSTOPERATIVE CHEMORADIOTHERAPY

The long-term results of combined treatment of 79 patients with locally advanced resectable gastric cancer IV stage (T4N1–3M0) with the use of extended-combined operations and postoperative chemoradiotherapy (I group) were studied. As a control group we studied the results of treatment of 132 patients who received postoperative chemotherapy (II group) and 117 patients who underwent only surgery (III group). General and recurrence-free 3-year survival in group I composed 38,9% and 20,9%, group II – 22,9% and 3,4%, group III – 24,4% and 10,5%, respectively (p <0,003). The use of postoperative chemoradiotherapy was the most effective for the Borrmann III–IV macroscopic forms of the tumors, low and undifferentiated cancer, with proximal localization, subtotal and total tumor of the stomach. Carry out of the postoperative chemoradiotherapy of locally advanced gastric cancer provides a high degree of local control of the tumor. Local recurrence in patients of group I wasn’t observed, whereas in patients of II and III groups it was detected in 12,2% and 21,2% of cases respectively.

Keywords: gastric cancer, postoperative chemotherapy, radiotherapy
p. 99 – 106 of the original issue
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