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Year 2007 Vol. 15 No 3

ORIGINAL INVESTIGATIONS

SPIRIDONOV S.V., ZHARKOV V.V., KURCHIN V.P.

REMOTE RESULTS OF POST-OPERATIVE RADIATION THERAPY IN PATIENTS WITH NON SMALL-CELLED LUNG CANCER WITH METASTASIS IN MEDIASTINAL LYMPH NODES

Unsatisfactory statistics of 3 and 5-year survival in the stage III of non small-celled lung cancer with mediastinal lymph nodes lesion requires searching new approaches for extension of patients’ life and clinical recovery. The aim of this study is the comparison of adjuvant radiation therapy effectiveness in total focal dose of 40 and 50GR for patients with non small-celled lung cancer with metastases in mediastinal lymph nodes, who underwent radical surgery operations. On application of adjuvant radiation therapy in total focal dose of 50 GR throughout the three-year period of observation, the survival rate is higher than in case of postoperative radiation therapy application in total focal dose of 40 GR, the difference was statistically reliable. The leading cause of patients’ death is distant metastases. High frequency of metastases in the bone should be noted. Taking into account this fact as well as the increasing evidence of adjuvant chemotherapy effectiveness, the question of systemic impact on the tumor after radical surgical treatment should be more pointed.

Keywords: non small-celled lung cancer, adjuvant radiation therapy.
p. 16 - 26 of the original issue
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