Year 2007 Vol. 15 No 3

ORIGINAL INVESTIGATIONS

GIDRANOVICH A.V.

AUTOCRINE CELL MOBILITY FACTOR IN THE BREAST CANCER PATIENTS BLOOD SERUM

The analysis of autocrine mobility factor (AMF) activity in the blood serum of healthy donors and breast cancer patients on different stages of the disease was performed. Statistically significant increase of AMF activity in serum of the breast cancer patients was determined. The activity of AMF in the metastasis breast cancer patients serum was maximal. In the 1st, 2nd, 3rd stages of breast cancer the stable elevated level of AMF activity was observed. Stage 4 was characterized by highly elevated activity of AMF. The high increase of AMF in breast cancer patients serum may be a screening marker of early hematogenic metastasis risk.

Keywords: breast cancer, autocrine factor of mobility, AMF.
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