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Year 2023 Vol. 31 No 4

SCIENTIFIC PUBLICATIONS

H.A. POPEL, I.A. MAISEYENKA, R.R. ZHMAILIK, M.G. KALIADKA, YU. P. OSTROVSKY

EVALUATION OF THE COAGULATION HEMOSTASIS IN ANIMALS USING ROTATIONAL THROMBOELASTOMETRY AFTER ABDOMINAL AORTIC REPLACEMENT

Republican Scientific and Practical Center of Cardiology, Minsk,
Republic of Belarus

Objective. To study changes in coagulation hemostatic system of animals after abdominal aortic replacement.
Methods. The study was conducted on female white pigs (n = 12). The animals were divided into 2 groups: group 1 – with implantation of a synthetic vascular graft (SG) made of Dacron coated with modified gelatin, group 2 – with implantation of a biological vascular graft (BG) made of bovine xenopericardium. In the EXTEM, INTEM, FIBTEM and APTEM tests, the following parameters were analyzed: CT (clotting time), CFT (clot formation time), angle α, A10, A20, MCF (maximum clot firmness), ML (maximal lysis). Additionally, coagulation index, maximum clot elasticity and thrombodynamic potential index were calculated.
Results. On 1st day after operation, a slight increase in CT relative to the upper limit of the reference interval was revealed in the group of animals with biological vascular graft in INTEM, FIBTEM and APTEM tests, as well as intergroup statistically significant differences in CT values in the FIBTEM test (Me 56.0 (52.0-58.5) s and Me 49.0 (46.0-49.8) s in the BG and SG group, respectively, p = 0.029). In 14 days after surgery, animals with biological vascular graft, compared with the group of animals with a synthetic vascular graft, had higher median CT values in the EXTEM (∆ CT = 17.5 s; p = 0.041), INTEM (∆ CT = 69.0 s; p = 0.004) and APTEM (∆ CT = 9.5 c; p = 0.025) tests, as well as higher values of the clot formation time in the INTEM, FIBTEM, APTEM tests while maintaining the values of the remaining parameters within the reference intervals. By the 21st day after surgery, in the group of animals with biological graft, compared with the group of animals with synthetic graft, higher values of CT were also detected in the INTEM test: Me 137.0 (127.0-147.8) s and Me 112.0 (107.5-122.5) s respectively, (p = 0.037). At the same time, statistically significant differences in the values of CFT in the APTEM test were revealed: in the group with biological graft – Me 55.0 (51.3-60.5) s, in the group with synthetic graft – Me 41.5 (38.5-43.8) s (p = 0.004).
Conclusion. Higher values of clot formation time in the EXTEM and INTEM tests, while maintaining the values of other parameters within the boundaries of the reference intervals, indicate a slower onset of fibrin formation and, accordingly, lower thrombogenicity of a biological vascular graft, compared to a synthetic vascular graft.

Keywords: rotational thromboelastometry, biological vascular graft, xenopericardium, aorta, pigs, hemostasis.
p. 265-276 of the original issue
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Address for correspondence:
220036, Republic of Belarus,
Minsk, R. Luxemburg Str. 110B,
Republican Scientific
and Practical Center «Cardiology»,
Vascular Surgery Research Laboratory,
tel.: +375 17 201-28-08,
e-mail: hpopel@mail.ru,
Popel Henadzi A.
Information about the authors:
Popel Henadzi A., PhD, Associate Professor, Head of Vascular Surgery Research Laboratory, Republican Scientific and Practical Center of Cardiology, Minsk, Republic of Belarus.
https://orcid.org/0000-0002-1140-0806
Maiseyenka Ivan A.,Intern at Cardiac Surgery Department No. 1, Researcher at Vascular Surgery Research Laboratory, Republican Scientific and Practical Center of Cardiology, Minsk, Republic of Belarus.
https://orcid.org/0000-0001-5403-7464
Zhmailik Ruslan R., Cardiac Surgeon at Cardiac Surgery Department No. 1, Researcher at Vascular Surgery Research Laboratory, Republican Scientific and Practical Center of Cardiology, Minsk, Republic of Belarus.
https://orcid.org/0000-0001-6342-3527
Kaliadka Marina G., PhD, Head of Clinical Diagnostic Laboratory, Republican Scientific and Practical Center of Cardiology, Minsk, Republic of Belarus.
https://orcid.org/0000-0001-6357-2143
Ostrovsky Yury P., MD, Professor, Academician of NAS of Belarus and RAS, Vice-Director for Innovative Development and High Technologies, Republican Scientific and Practical Center of Cardiology, Minsk, Republic of Belarus.
https://orcid.org/0000-0001-6826-3200

M.D. LEVIN 1, 2, V.I. AVERIN 1, 3, YU.G. DEGTYAREV 1, 4

ETIOLOGY AND PATHOGENESIS OF THE SUPERIOR MESENTERIC ARTERY SYNDROME. HYPOTHESIS

State Institution "Republican Scientific and Practical Center of Pediatric Surgery" ¹,
Minsk, Republic of Belarus,
Dorot-Netanya Geriatric Medical Center, Israel ²,
Belarusian State Medical University ³, Minsk,
Belarusian Medical Academy of Postgraduate Education 4, Minsk,
Republic of Belarus

Objective. It is currently believed that the cause of superior mesenteric artery syndrome (SMAS) is compression of the duodenum in the angle between the aorta and superior mesenteric artery (SMA). It is recognized that a decrease in aortomesenteric angle (AMA) < 25° and intervascular distance < 8 mm, caused by fat loss, is characteristic of SMAS. Based on these statements, surgeons operate on patients with symptoms of dyspepsia only on a reduction of AMA. This study is devoted to the analysis of the literature, including four own studies on this issue.
Methods. 79 PubMed and PMC articles describing 211 cases of SMAS from 1990 to 2015 have been analyzed
Results. Measurement of the length of the constriction in the third part of the duodenum on the radiograms from the available sources showed that its true length ranged from 2.5 to 4.2 (3.30±0.15) cm and began a few centimeters cranial to the AMA. Therefore, it could not be caused by compression in the AMA. In terms of length (3.20±0.15 cm) and location, this constriction corresponded to Ochsner’s sphincter, which normally short-term contracts to prevent the penetration of an acid bolus into the jejunum. Conscientious studies have shown that AMA is proportional to BMI, i.e., a decrease in AMA is observed in all thin people. An analysis of 211 cases of SMAS made it possible to differentiate two types of diseases. In 101 patients, the disease occurred acutely 1-53 (8.2±1.9) days after stressful situations, accompanied by a catabolic reaction and hypersecretion of hydrochloric acid. In 110 patients, SMAS developed 3-72 (17.2±3.2) months after the diagnosis of a acid-depended diseases.
Conclusion. The analysis led to the conclusion that hypersecretion of hydrochloric acid causes an increase in tone and hypertrophy of the Ochsner’s sphincter, and the clinic of the disease depends on the degree of its dyskinesia, where there is no place for surgical treatment at the so-called SMAS.

Keywords: superior mesenteric artery syndrome, aortomesenteric angle, duodenum, sphincters, conservative treatment
p. 277-287 of the original issue
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Address for correspondence:
4220200, Dorot,
State Geriatic Center,Netanya,
Amnon ve-Tamar 1, Israil
Tel. +972 538281393,
e-mail: nivel70@hotmail.com,
Levin Mikhail D.
Information about the authors:
Levin Mikhail D. MD, Radiologist, State Gerriatric Center (Djrot), Netanya, Israil.
https://orcid.org/0000-0001-7830-1944
Averin Vasily I. MD, Professor, Head of the Department of Pediatric Surgery, Belorussian State Medical University, Minsk, Republic of Belarus.
https://orcid.org/0000-0003-3343-8810
Degtyarev Yury G. Professor of the Department of Pediatric Surgery, Belorussian State Medical University, Minsk, Republic of Belarus.
https://orcid.org/0000-0002-2696-4989

SH. V. TIMERBULATOV, R.B. SAGITOV, M. V. TIMERBULATOV, I.Z. AKCHURIN, R.R. AKHMEROV, I.D. GAYAZOV, A.R. GAFAROVA, V. M. TIMERBULATOV

SOME ISSUES OF REFINED DIAGNOSIS AND CHOICE OF TREATMENT METHOD FOR COMPLICATED ACUTE APPENDICITIS IN RECENT YEARS

BSMU of the Ministry of Health of Russia, Ufa,
Russian Federation

Objective. To study the trends in the refined diagnosis and in the case of choice of surgical treatment methods over the past 4 years.
Methods. A retrospective observational study of 1095 patients with acute appendicitis for 2019-2022 was conducted. The article presents data indicating a significant impact of comorbid pathologies on an increase iof the number of complications and mortality; in 2020 by 10.2%, in 2021 – by 19% compared with the pre-COVID 2019 year, there was no statistically significant increase in the proportion of patients hospitalized later than 24 hours from the onset of the disease. Clinical and laboratory evaluations at admission of patient were performed according to Alvarado scoring system. The Alvarado Score for acute apendicitis predicts likelihood of appendicitis diagnosis.. Ultrasound was performed for the vast majority of patients (up to 94%), laparoscopy was considered not only as a diagnostic, but also as a therapeutic method. CT of abdominal organs was performed in diagnostically difficult cases, with severe co-morbid pathology which associated with increased morbidity and mortality (colon cancer (5.3-11.4% in various years).
Results. The informativeness of an assessment according to the Alvarado Score, is quite high (86%), according to its results, from 7% to 14% patients were sent for ambulatory observation. The sensitivity and specificity of ultrasound in acute appendicitis was 83% and 70%, respectively, especially this method is informative for the diagnosis of peritonitis and abscesses. Determining the complexity of diagnosis was associated with the need to clarify the presence or complications of SARS-CoV-2 infection. Laparoscopic appendectomy was performed in 60.35%, open – 36.95% of patients (74.2% in 2022). An increase of laparoscopic operations during the COVID-19 pandemic was reported.. Laparoscopic appendectomy of complicated appendicitis changed in various years - from 57.6% to 77.4%, in the case of peritonitis - from 24.07% to 57.6%. Postoperative complications were more common after laparoscopic appendectomy – 4.9% versus 2.35% in the case of the open appendectomy. There were no fatal cases during the study period.
Conclusion. Over the past 3 years of the pandemic, approaches to the diagnosis and treatment of acute appendicitis have not changed, except for the wider use of imaging methods. The immediate results of treatment for 2020-2022 were compared with the «pre-pandemic» 2019. It could influence the frequency of laparoscopic surgery in 2020-2022. As such, the Alvarado scoring system may be utilized to better predict whether a patient has appendicitis.

Keywords: acute appendicitis, complicated appendicitis, diagnosis, laparoscopic appendectomy, open-method appendectomy, postoperative complications.
p. 288-300 of the original issue
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Address for correspondence:
450008, Russian Federation,
Ufa, Lenin st., 3,
Bashkir State Medical University,
Department of Surgery with
a Course of Endoscopy, IDPO,
tel.: +73472555457,
e-mail: argafarova@yandex.ru,
Gafarova Aigul R.
Information about the authors:
Timerbulatov Shamil V., MD, Professor of the Department of Surgery with the course of Endoscopy at the Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russian Federation.
https://orcid.org/0000-0002-4832-6363
Sagitov Ravil B., MD, Associate Professor at the Department of Surgery with the course of Endoscopy at the Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russian Federation.
https://orcid.org/0000-0001-7459-388X
Timerbulatov Mahmud V., MD, Professor, Head of the Department of Faculty Surgery of the Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russian Federation.
https://orcid.org/0000-0002-6664-1308;
Akchurin Ildar Z., Assistant of the Department of Surgery with the course of Endoscopy Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russian Federation.
https://orcid.org/0009-0003-3358-8592
Akhmerov Ruslan R., PhD, Assistant of the Department of Surgery with the Course of Endoscopy Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russian Federation.
https://orcid.org / 0000-0002-9351-4582
Gayazov Ilmir D, Graduate Student of the Department of Surgery with a Course of Endoscopy of the Bashkir State Medical University of the Ministry of Health of Russia. Ufa, Russian Federation.
https://orcid.org/0009-0005-4710-7299
Gafarova Aigul Radikovna, Assistant of the Department of Surgery with a Course of Endoscopy Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russian Federation.
https://orcid.org/0000-0003-2874-7213
Timerbulatov Vil M, MD, Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Surgery with the course of Endoscony IDPO Bashkir State Medical University of the Ministry of Health of Russia, Ufa, Russian Federation.
https://orcid.org/0000-0003-1696-3146

P.A. ERASHOV 1, V.L. DENISENKO 1, 2

CURRENT APPROACHES TO GROIN HERNIAS MANAGEMENT

Vitebsk State Medical University 1,
Vitebsk Regional Clinical Specialized Centre 2, Vitebsk,
Republic of Belarus

Surgeries for groin hernias (GH) are among the most common elective surgical interventions. More than 20 million inguinal hernioplasties are performed worldwide every year. Most patients with GH belong to the working-age population. Therefore, the treatment of GH has a large socioeconomic burden on healthcare systems around the world.
Over the past 50 years, approaches to the surgical treatment of GH have undergone significant changes. And work to improve treatment tactics for such patients is still ongoing. Our aim was to analyze recent reviews, meta-analyses and clinical guidelines regarding the management of patients with GH.
It was found that etiopathogenetically justified treatment options for GH are tension-free hernioplasties with a mesh implantation (Lichtenstain plasty, transabdominal preperitoneal plasty (TAPP) and total preperitoneal plasty (TEP)). When choosing a surgical option, a tailored approach should be used, taking into account the type of hernia, gender and age of the patient. Hernioplasty using own patient`s tissues is undesirable. It only may be used in exceptional cases.
We also reviewed the main complications of surgical treatment of GH, methods for their prevention and management.

Keywords: inguinal hernia, groin hernia, hernias management, complications of hernioplasty, guidelines
p. 301-311 of the original issue
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Address for correspondence:
210009, Republic of Belarus,
Vitebsk, Frunze prospect,
Vitebsk State Medical University,
Chair of General Surgery,
å-mail: generalsurgeryvsmu@mail.ru,
ph.: +375 33 675-22-21
Pavel Erashov À.
Information about the authors:
Erashov P.A., assistant of the Chair of General Surgery, Vitebsk State Medical University, Vitebsk, Belarus.
http://orcid.org/0009-0008-7545-6228
Denisenko V.L., Doctor of Medical Sciences, professor of the Chair of General Surgery, Vitebsk State Medical University, Vitebsk, Belarus.
http://orcid.org/0000-0003-2394-340X

O.V. PASICHNYK, V.S. KONOPLITSKYI, Y.YE. KOROBKO, A.I. SASIUK, O.O. LUKIIANETS

PARTICULARITIES OF MELANOCYTIC NEVUSES OF CHILDREN

Vinnitsa National Medical University named after M.I. Pirogov, Vinnytsia,
Ukraine

Objective. Determination of clinical and morphological features of the recurrent course of melanocytic skin lesions in children.
Methods. The study is based on the data analysis of 468 histological protocols of removing nevi taken from the archives of «Vinnytsia Regional Pathological Bureau of the Vinnytsia Regional Council» (Ukraine) during the whole period of the study (from 2018 to 2020).
Results. In general, the terms between the primary surgical removal / «self-removal» of the pigmented formation before the recurrence of melanocytic nevi made up 3-6 months. Melanocytic nevi recurrences in children occurred in different areas of the skin, but most often on the trunk (44.44%) and scalp and neck (27.78%). A typical dermatoscopic sign of pigmented nevi recurrences was the presence of scar tissue on the periphery of the lesion. The confines of a recurrent pigmented tumor on dermatoscopy were not clearly symmetrical.
Conclusion. The existing difference in the morphological structure of different types of melanocytic nevi explains the low frequency of clinical and histological diagnoses in recurrent pathology in childhood; the possibility of atypical cells presence of melanocytic origin in the scar area necessitates differential diagnosis in case of the skin melanoma recurrence, especially in cases of histological verification absence of the primary melanocytic lesion.

Keywords: melanocyte nevus, surgery, children, oncology
p. 312-321 of the original issue
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Address for correspondence:
21029, Ukraine,
Vinnytsia, Mykoly Vashchuka Str., 23- 34,
National Pirogov Memorial Medical University,
the Department of Pediatric Surgery,
tel. +380634369982,
e-mail: lundqist747@gmail.com,
Korobko Yurii Ye.
Information about the authors:
Pasichnyk Oleh Vadymovych , Assistant Professor of the Department of Children Surgery National Pirogov Memorial Medical University, Vinnytsia, Ukraine.
http://orcid.org/0000-0001-8302-3520.
Konoplitskyi Viktor Serhiiovych, MD, Professor, Head of the Department of Pediatric Surgery National Pirogov Memorial Medical University, Vinnytsia, Ukraine.
http://orcid.org/0000-0001-9525-1547.
Korobko Yurii Yevheniiovych, Assistant Professor of the Department of Children Surgery National Pirogov Memorial Medical University, Vinnytsia, Ukraine.
http://orcid.org/0000-0002-3299-878X.
Sasiuk Anatolii Ivanovych, Associate Professor of the Department of Children Surgery National Pirogov Memorial Medical University, Vinnytsia, Ukraine.
http://orcid.org/0000-0001-7454-2986.
Lukiianets Oleh Oleksandrovych, Assistant Professor of the Department of Children Surgery National Pirogov Memorial Medical University, Vinnytsia, Ukraine.
http://orcid.org/0000-0001-8811-080X.

A.V. OREKHVA 1, 2, E.A. SHLIAKHTUNOV 2, I.V. ZHILTSOV 2, V.M. SEMENOV 2, E.V. KARCHMIT 1, G.M. SHAPPO 2, , J.N. LYACH 1, A.V. OREKHVA 3

MONITORING OF MINIMAL RESIDUAL DISEASE IN COLORECTAL CANCER BASED ON THE ASSESSMENT OF SURVIVIN (BIRC5) MRNA EXPRESSION IN CIRCULATING TUMOR CELLS

Health Institution "Vitebsk Regional Clinical Oncology Dispensary" 1,
Educational Establishment "Vitebsk State Medical University" 2,
Health Institution "Vitebsk Regional Clinical Diagnostic Center” 3, Vitebsk,
Republic of Belarus

Objective. To assess the clinical significance of survivin (BIRC5) mRNA expression in circulating tumor cells (CTCs) in colorectal cancer (CRC).
Methods. The study involved 130 patients (109 patients with colorectal cancer and 21 patients with colon adenomas). All patients underwent complete tumor resection (radical surgery – 102 (93.6%), cytoreductive – 7 (6.4%)). Monitoring of survivin mRNA (BIRC5) expression in the CTC was performed within 9 months after surgery. The expression study was performed using RT-PCR, the normalized expression of the BIRC5 gene in the CTCs was examined.
Results. A high level of survivin (BIRC5) mRNA expression was found in CTCs in CRC compared to adenomas (p<0.001), both prior surgery M±SD (1.175±1.33 and 0.052±0.11) and after 3 months M±SD (1.015±0.93 and 0.018±0.002). A relationship was found between the presence of CTCs in patients prior surgery and damage of regional lymph nodes (p=0.032), stage of the tumor process (p=0.011), tumor size (p=0.038), degree of tumor differentiation (p=0.039), positive expression of survivin mRNA ( BIRC5) in tumor material (p=0.044) . In 6 and 9 months after surgery, CTCs persist in the bloodstream, even despite adjuvant chemotherapy in patients with stage III disease (p=0.015 and p=0.012).
Conclusion. Survivin is a highly sensitive tumor marker in CRC due to its overexpression in the CTC. Overexpression of survivin mRNA in CRC has been identified as negative prognostic factor and directly depends on the tumor lesion of the regional lymph nodes, the stage of the disease, the degree of tumor differentiation, and the size of the tumor. In 9 months after radical surgery determination of survivin (BIRC5) mRNA expression in the CTC can be used for assessment of minimal residual disease and considered as a powerful prognostic factor of the overall survival rate.

Keywords: BIRC5, survivin, minimal residual disease, circulating tumor cells, colorectal cancer
p. 322-331 of the original issue
References
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Address for correspondence:
210009, Republic of Belarus,
Vitebsk, Frunze Ave., 27,
Vitebsk State Medical Univercity.
tel.: +375-33-900-44-00,
e-mail: dr.orehva@yandex.ru,
Orekhva Andrey V.
Information about the authors:
Orekhva Andrey V., Oncologist-Surgeon of the Oncological Abdominal Department of Vitebsk Regional Clinical Oncological Dispensary, Applicant for the Department of Oncology with Courses of LD, LT, FPC and PC. Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0001-9145-4216
Shlyakhtunov Evgenij A., MD, Associate Professor, Head of the Department of Oncology with Courses of LD, LT, FPC and PC Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0002-5906-5373
Semenov Valery M., MD, Professor, Head of the Department of Infectious Diseases, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0002-7029-9226
Zhiltsov Ivan V., MD, Professor, Head of the Department of Evidence-Based Medicine and Clinical Diagnostics FPC and PC, Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0002-4912-2880
Shappo Galina M., PhD, Associate Professor of the Department of Oncology with Courses of LD, LT, FPC and PC Vitebsk State Medical University, Vitebsk, Republic of Belarus.
https://orcid.org/0000-0002-2147-3937
Lyakh Yan N., Oncologist of the Oncological Polyclinic Department of the Vitebsk Regional Clinical Oncological Dispensary, Vitebsk, Republic of Belarus.
https://orcid.org/0009-0001-2385-4880
Karchmit Evgenia V., Head of the Oncological Polyclinic Department of Vitebsk Regional Clinical Oncological Dispensary, Vitebsk, Republic of Belarus.
https://orcid.org/0009-0009-0231-7945
Orekhva Alina V., Radiologist of the Department of Radiation Diagnostics of Vitebsk Regional Clinical Diagnostic Center, Vitebsk, Republic of Belarus.
https://orcid.org/0009-0007-4484-6736

REVIEWS

A.V. SAZHIN 1, T.V. NECHAY, S.I. PANIN 2, V.S. ZAMARAEV 2, N.A. SHCHERBAKOV 1, A.A. GOFMAN 1,
V.A. DONETSKOVA 1, A.G. YULDASHEV 1, A.A. KUZNETSOV 2

GENETIC PREDICTORS OF COLORECTAL ANASTOMOTIC FAILURE – NEW HORIZONS OF PERSONALIZED SURGERY
OR UTOPIA? OVERVIEW OF THE SUBJECT FIELD

Pirogov Russian National Research Medical University 1, Moscow,
Volgograd State Medical University 2, Volgograd,
Russian Federation

Objective. To perform the analysis of genetic markers as possible predictors of colorectal anastomotic leakage.
Methods. A systematic search, selection and assessment of methodological quality of original primary studies published until April 2022 were carried out independently by co-authors in accordance with recommendations from Federal State Budgetary Institution «Center for examination and quality control of medical care» (Omelyanovsky V.V., 2019) and with the guidance of the Cochrane community (Higgins J. et al., 2022).
Results. This review shows possibility of evaluation of SNP signatures in risk stratification of colorectal anastomotic leakage. It was found out that anastomotic leakage in colonic surgery was statistically significant and was more frequent in group of patients with CC-genotype of genes encoding prostaglandin endoperoxide synthase 2 (PTGS2-765) and matrix metalloproteinase 2 (MMP2-1306) and GG genotype tissue inhibitor of metalloproteinase 2 (TIMP2-303). However, the nature and limited number of publishing primary studies bring the challenge to conduct mathematically determined meta-analysis of genetic polymorphisms underlying colon anastomotic leakage.
Conclusion. Obtained results may suggest a perspective direction of personalized studies in the field of prediction of anastomotic leakage in colonic surgery at the genome level.

Keywords: anastomotic leakage, personalized medicine, genetic markers
p. 332-339 of the original issue
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Address for correspondence:
117997, Russian Federation,
Moscow, Ostrovityanov st., 1,
Federal State Autonomous Educational Institution of Higher Education «Russian National Research Medical University named after N.I. Pirogov»
of the Ministry of Health of the Russian Federation, Department of Faculty Surgery No. 1 ,
tel.: +7 977 885-11-23,
e-mail: nikita.shche98@gmail.com,
Shcherbakov Nikita Alekseevich
Information about the authors:
Sazhin Alexander V., Corresponding Member of the Russian Academy of Sciences, MD, Professor, Director of the Research Institute of Clinical Surgery, Head of the Department of Faculty Surgery No. 1, Russian National Research Medical University. N.I. Pirogov, Moscow, Russian Federation. http://orcid.org/0000-0001-6188-6093
Nechay Taras V., MD, Associate Professor, Professor of the Department of Faculty Surgery No. 1, Russian National Research Medical University. N.I. Pirogova, Deputy Director of the Research Institute of Clinical Surgery, Moscow, Russian Federation.
http://orcid.org/0000-0003-0769-5282Associate Professor,
Panin Stanislav I., MD, Professor; Head of the Department of General Surgery, Volgograd State Medical University, Volgograd, Russian Federation.
http://orcid.org/0000-0003-4086-2054;
Zamaraev Valery S. MD, Professor, Professor of the Department of Microbiology, Virology, Immunology with a course of clinical microbiology, Volgograd State Medical University, Volgograd, Russian Federation. http://orcid.org/0000-0001-7442-9940;
Shcherbakov Nikita A., Resident of the Department of Faculty Surgery No. 1, Russian National Research Medical University. N.I. Pirogova, Laboratory Assistant at the Research Institute of Clinical Surgery, Moscow, Russian Federation.
http://orcid.org/0000-0002-5250-6359;
Gofman Anna A., Student, Laboratory Assistant at the Research Institute of Clinical Surgery, Moscow, Russian Federation.
http://orcid.org/0000-0002-8635-0786
Donetskova Victoria À., Student, Laboratory Assistant at the Research Institute of Clinical Surgery, Moscow, Russian Federation. http://orcid.org/0000-0003-2462-7556.
Yuldashev G. Anvarbek, PhD, Scientist at the Research Institute of Clinical Surgery, Moscow, Russian Federation.
http://orcid.org/0000-0002-1582-5350
Kuznetsov Alexander A., PhD, Associate Professor, Department of Urology, Volgograd State Medical University, Volgograd, Russian Federation. http://orcid.org/0000-0002-7026-1746;
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