2011 ã. ¹6 Òîì 19

ËÅÊÖÈÈ, ÎÁÇÎÐÛ

Â.ß. ÕÐÛÙÀHÎÂÈ×, Ñ.È. ÒÐÅÒÜßÊ, Â.À. ÊÎHÄÐÀÒÎÂÈ×, À.Ì. ÏÈÑÀÐÅHÊÎ, Ê.Ñ. ÊÎÌÈÑÑÀÐÎÂ

ÀÓÒÎÒÐÀHÑÏËÀHÒÀÖÈß ÏÀÐÀÙÈÒÎÂÈÄHÛÕ ÆÅËÅÇ ÊÀÊ ÌÅÒÎÄ ÏÐÎÔÈËÀÊÒÈÊÈ ÏÎÑËÅÎÏÅÐÀÖÈÎHHÎÃÎ ÃÈÏÎÏÀÐÀÒÈÐÅÎÇÀ

ÓÎ «Áåëîðóññêèé ãîñóäàðñòâåííûé ìåäèöèíñêèé óíèâåðñèòåò»,
ÓÇ «Ìèíñêèé ãîðîäñêîé êëèíè÷åñêèé îíêîëîãè÷åñêèé äèñïàíñåð»,
ÃÓÎ «Áåëîðóññêàÿ ìåäèöèíñêàÿ àêàäåìèÿ ïîñëåäèïëîìíîãî îáðàçîâàíèÿ»,
Ðåñïóáëèêà Áåëàðóñü

 ñòàòüå ïðåäñòàâëåí îáçîð èññëåäîâàíèé, ïîñâÿùåííûõ ïðèìåíåíèþ àóòîòðàíñïëàíòàöèè ïàðàùèòîâèäíûõ æåëåç äëÿ ïðîôèëàêòèêè ïîñëåîïåðàöèîííîãî ãèïîïàðàòèðåîçà. Ðàññìîòðåíû èñòîðè÷åñêèå è êëèíè÷åñêèå àñïåêòû ïðîáëåìû, à òàêæå ïåðñïåêòèâû åå ðåøåíèÿ. Àíàëèç ëèòåðàòóðû ïðîäåìîíñòðèðîâàë, ÷òî íàðÿäó ñ ñîõðàíåíèåì ïàðàùèòîâèäíûõ æåëåç in situ, èìåþùèõ óäîâëåòâîðèòåëüíîå êðîâîñíàáæåíèå, ýôôåêòèâíîé àëüòåðíàòèâîé ïîääåðæàíèÿ ïàðàòèðåîèäíîé ôóíêöèè ÿâëÿåòñÿ ïàðàòèðåîèäíàÿ àóòîòðàíñïëàíòàöèÿ (ÏÀ), ÷òî îñîáåííî àêòóàëüíî â îòíîøåíèè æåëåç ñ ñîìíèòåëüíîé æèçíåñïîñîáíîñòüþ. Íå âûçûâàåò ñîìíåíèÿ íåîáõîäèìîñòü âûïîëíåíèÿ àóòîòðàíñïëàíòàöèè ñëó÷àéíî óäàëåííûõ èëè ïîâðåæäåííûõ ïàðàùèòîâèäíûõ æåëåç.  òî æå âðåìÿ äî íàñòîÿùåãî âðåìåíè íå ðàçðàáîòàí íàèáîëåå îïòèìàëüíûé âàðèàíò ÏÀ, êîòîðûé áû ãàðàíòèðîâàë ñîõðàíåíèå ïàðàòèðåîèäíîé ôóíêöèè. Ñ öåëüþ óëó÷øåíèÿ ðåçóëüòàòîâ ÏÀ íåîáõîäèìî ïðîâåäåíèå äàëüíåéøèõ èññëåäîâàíèé, íàïðàâëåííûõ íà ðàçðàáîòêó íîâûõ õèðóðãè÷åñêèõ ïîäõîäîâ è ìåòîäîâ îöåíêè æèçíåñïîñîáíîñòè ïàðàùèòîâèäíûõ æåëåç. Äëÿ áîëåå ãëóáîêîãî ïîíèìàíèÿ ìîëåêóëÿðíûõ îñíîâ ÏÀ òðåáóåòñÿ èçó÷åíèå îñîáåííîñòåé ðåâàñêóëÿðèçàöèè, ðåèííåðâàöèè è ôóíêöèîíèðîâàíèÿ ðåèìïëàíòèðîâàííîé ïàðàòèðåîèäíîé òêàíè.

Êëþ÷åâûå ñëîâà: àóòîòðàíñïëàíòàöèÿ, îöåíêà ôóíêöèè òðàíñïëàíòàòà, ãèïîêàëüöèåìèÿ, ïàðàùèòîâèäíàÿ æåëåçà, òèðåîèäýêòîìèÿ
ñ. 106 – 114 îðèãèíàëüíîãî èçäàíèÿ
Ñïèñîê ëèòåðàòóðû
  1. Katz, A. D. Parathyroid autotransplantation in patients with parathyroid disease and total thyroidectomy / A. D. Katz // Am. J. Surg. – 1981. – Vol. 142. – P. 490-493.
  2. Transplantation of the parathyroid glands: current status / S. A. Wells [et al.] // Surg. Clin. N. Am. – 1979. – Vol. 59. – P. 167-177.
  3. Baumann, D. S. Parathyroid autotransplantation / D. S. Baumann, S. A. Jr. Wells // Surgery. – 1993. – Vol. 113. – P. 130-133.
  4. Saxe, A. Parathyroid transplantation: a review / A. Saxe // Surgery. – 1979. – Vol. 95. – P. 507-526.
  5. Senapati, A. Parathyroid autotransplantation / A. Senapati, A. E. Young // Br. J. Surg. – 1979. – Vol. 77. – P. 1171-1174.
  6. Parathyroid autotransplantation during thyroidectomy. Results of long-term follow-up / J. A. Olson Jr. [et al.] // Ann. Surg. – 1996. – Vol. 223. – P. 472-480.
  7. Halsted, W. F. P. Auto and iso-transplantation in dogs of the parathyroid glandules / W. F. P. Halsted // J. Exp. Med. – 1979. – Vol. 11. – P. 175-198.
  8. Lahey, F. H. The transplantation of parathyroids in partial thyroidectomy / F. H. Lahey // Surg. Gynecol. Obstet. – 1926. – Vol. 62. – P. 508-509.
  9. Cattell, R. B. Parathyroid transplantation – a report of autografts of parathyroid glands removed during thyroidectomy / R. B. Cattell // Am. J. Surg. – 1929. – Vol. 7. – P. 4-8.
  10. Shambaugh, P. Autotransplantation of parathyroid gland in the dog / P. Shambaugh // Arch. Surg. – 1936. – Vol. 32. – P. 709-720.
  11. Experimental cryopreservation and autotransplantation of parathyroid glands: technique and demonstration of function / G. S. Leight [et al.] // Ann. Surg. – 1978. – Vol. 188. – P. 16-21.
  12. Experimental autotransplantation of the parathyroid gland / S. Prigouris [et al.] // Br. J. Surg. – 1996. – Vol. 83. – P. 410-412.
  13. Hickey, R. C. Human parathyroid autotransplantation: proved function by radioimmunoassay of plasma parathyroid hormone / R. C. Hickey, N. A. Samaan // Arch. Surg. – 1975. – Vol. 110. – P. 892-895.
  14. Transplantation of the parathyroid glands in man: clinical indications and results / S. A. Jr. Wells [et al.] // Surgery. – 1975. – Vol. 78. – P. 34-44.
  15. Ready, A. R. Complications of thyroidectomy / A. R. Ready, A. D. Barnes // Br. J. Surg. – 1994. – Vol. 81. – P. 1555-1556.
  16. Total thyroidectomy: The preferred option for multinodular goiter / T. S. Reeve [et al.] // Ann. Surg. – 1987. – Vol. 2. – P. 782-786.
  17. Hypocalcaemia following thyroid surgery: Incidence and prediction of outcome / F. Pattou [et al.] // World J. Surg. – 1998. – Vol. 22. – P. 718-724.
  18. van Heerden, J. A. Early postoperative morbidity after surgical treatment of thyroid carcinoma / J. A. van Heerden, M. A. Groh, C. S. Grant // Surgery. – 1986. – Vol. 101. – P. 224-227.
  19. Clark, O. H. Total thyroidectomy: the treatment of choice for patients with differentiated thyroid cancer / O. H. Clark // Ann. Surg. – 1982. – Vol. 196. – P. 361-370.
  20. The morbidity of total thyroidectomy / E. F. Scanlon [et al.] // Arch. Surg. – 1981. – Vol. 116. – P. 568-571.
  21. Jacobs, J. K. Total thyroidectomy: a review of 213 patients / J. K. Jacobs, J. W. J. Aland, J. F. Ballinger // Ann. Surg. – 1983. – Vol. 197. – P. 542-549.
  22. Schwartz, A. E. Preservation of parathyroid glands in total thyroidectomy / A. E. Schwartz, E. W. Friedman // Surg. Gynecol. Obstet. – 1987. – Vol. 165. – P. 327-332.
  23. Total thyroidectomy: complications and technique / J. K. Harness [et al.] // World J. Surg. – 1986. – Vol. 10. – P. 781-786.
  24. Local complications after surgical resection for thyroid carcinoma / M. B. Flynn [et al.] // Am. J. Surg. – 1994. – Vol. 168. – P. 404-407.
  25. Complications of thyroid surgery / D. B. de Roy van Zuidewijn [et al.] // Ann. Surg. Oncol. – 1995. – Vol. 2. – P. 56-60.
  26. Operative management of thyroid disease: technical considerations in a residency training program / W. C. Pederson [et al.] // Am. J. Surg. – 1984. – Vol. 148. – P. 350-352.
  27. Post-thyroidectomy hypocalcemia. Incidence and risk factors / D. J. Wingert [et al.] // Am. J. Surg. – 1986. – Vol. 152. – P. 606-610.
  28. Risk of complication following thyroidectomy / M. R. Burge [et al.] // J. Gen. Intern. Med. – 1998. – Vol. 13. – P. 24-31.
  29. Farrar, W. B. Surgical management of papillary and follicular carcinoma of thyroid / W. B. Farrar, M. Cooperman, A. G. James // Ann. Surg. – 1980. – Vol. 192. – P. 701-704.
  30. Ipsilateral lobectomy versus bilateral lobar resection in papillary thyroid carcinoma: a retrospective analysis of surgical outcome using a novel prognostic scoring system / I. D. Hay [et al.] // Surgery. – 1987. – Vol. 102. – P. 1088-1095.
  31. Gann, D. S. Delayed hypocalcaemia after thyroidectomy for Graves’ disease is prevented by parathyroid autotransplantation / D. S. Gann, J. F. Paone // Ann. Surg. – 1979. – Vol. 190. – P. 508-513.
  32. Shaha, A. R. Parathyroid autotransplantation during thyroid surgery / A. R. Shaha, C. Burnett, B. M. Jaffe // J. Surg. Oncol. – 1991. – Vol. 46. – P. 21-24.
  33. Our technique of parathyroid autotransplantation in operation for papillary thyroid carcinoma / H. Funahashi [et al.] // Surgery. – 1993. – Vol. 114. – P. 92-96.
  34. Liu, Q. Total thyroidectomy for benign thyroid disease / Q. Liu, G. Djuricin, R. A. Prinz // Surgery. – 1998. – Vol. 123. – P. 2-7.
  35. Zedenius, J. Routine autotransplantation of at least one parathyroid gland during total thyroidectomy may reduce permanent hypoparathyroidism to zero / J. Zedenius, C. Wadstrom, L. Delbridge // Aust. N. Z. J. Surg. – 1999. – Vol. 69. – P. 794-799.
  36. Routine parathyroid autotransplantation during total thyroidectomy: the influence of technique / P. G. Gauger [et al.] // Eur. J. Surg. – 2000. – Vol. 166. – P. 605-609.
  37. Parathyroid autotransplantation in patients undergoing a total thyroidectomy: a review of 261 patients / R. P. Walker [et al.] // Otolaryngol. Head Neck Surg. – 1994. – Vol. 111. – P. 258-264.
  38. Paloyan, E. Successful autotransplantation of the parathyroid glands during total thyroidectomy for carcinoma / E. Paloyan, A. M. Lawrence, D. Paloyan // Surg. Gynecol. Obstet. – 1977. – Vol. 145. – P. 364-368.
  39. Lo, C. Y. Routine parathyroid autotransplantation during thyroidectomy / C. Y. Lo, K. Y. Lam // Surgery. – 2001. – Vol. 129. – P. 318-323.
  40. Lo, C. Y. Postoperative hypocalcaemia in patients who did or did not undergo parathyroid autotransplantation during thyroidectomy: a comparative study / C. Y. Lo, K. Y. Lam // Surgery. – 1998. – Vol. 124. – P. 1081-1087.
  41. Parathyroid autotransplantation in total thyroidectomy / M. A. Smith [et al.] // Am. Surg. – 1990. – Vol. 56. – P. 404-406.
  42. Heterotopic autotransplantation of parathyroid tissue in children undergoing total thyroidectomy / M. A. Skinner [et al.] // J. Pediatr. Surg. – 1997. – Vol. 32. – P. 510-513.
  43. Morbidity of thyroid surgery / R. Bergamaschi [et al.] // Am. J. Surg. – 1998. – Vol. 176. – P. 71–75.
  44. Safety of total thyroidectomy: review of 100 consecutive cases / F. Tovi // Laryngoscope. – 1989. – Vol. 99. – P. 1233-1237.
  45. Parathyroid autotransplantation with total thyroidectomy for thyroid carcinoma: long–term follow–up of grafted parathyroid function / T. Kikumori [et al.] // Surgery. – 1999. – Vol. 125. – P. 504-508.
  46. Salander, H. Incidence of hypoparathyroidism after radical surgery for thyroid carcinoma and autotransplantation of parathyroid glands / H. Salander, L. E. Tisell // Am. J. Surg. – 1977. – Vol. 134. – P. 358-362.
  47. Ohman, V. Function of the parathyroid glands after total thyroidectomy / V. Ohman, P. Granberg, B. Lindell // Surg. Gynecol. Obstet. – 1978. – Vol. 146. – P. 773-778.
  48. Complications of Thyroid Surgery: Analysis of a Multicentric Study on 14,934 Patients Operated on in Italy over 5 Years / L. Rosato [et al.] // World J. Surg. – 2004. – Vol. 28 (3). – P. 271-276.
  49. Walgenbach, S. Prospective evaluation of parathyroid graft function after total parathyroidectomy and heterotopic autotransplantation in renal hyperparathyroidism by bilateral determination of intact parathormone in cubital venous blood / S. Walgenbach, G. Hommel, T. Junginger // World J. Surg. – 1998. – Vol. 22. – P. 93-97.
  50. Results of heterotopic parathyroid autotransplantation: a 13-year experience / A. L. Feldman [et al.] // Surgery. – 1999. – Vol. 126. – P. 1042-1048.
  51. Parathyroid autotransplantation / M. Herrera [et al.] // Arch. Surg. – 1992. – Vol. 127. – P. 825-830.
  52. Prospective biochemical and scintigraphic evaluation of autografted normal parathyroid glands in patients undergoing thyroid operations / M. Sierra [et al.] // Surgery. – 1998. – Vol. 124. – P. 1005-1010.
  53. Lo, C. Y. Parathyroid autotransplantation during thyroidectomy: Documentation of graft function / C. Y. Lo, S. C. Tam // Arch. Surg. – 2001. – Vol. 136. – P. 1381-1385.
  54. Generalized primary parathyroid hyperplasia: Studies of the evolution of autogenous parathyroid graft function / L. E. Mallette [et al.] // Surgery. – 1983. – Vol. 93. – P. 254-259.
  55. Parathyroid–induced angiogenesis is VEGF-dependent / W. B. Carter [et al.] // Surgery. – 2000. – Vol. 128. – P. 458-464.
  56. Hyperparathyroidism after thyroid surgery and autotransplantation of histologically normal parathyroid glands / A. D’Avanzo [et al.] // J. Am. Coll. Surg. – 2000. – Vol. 190. – P. 546-552.
  57. Lo, C. Y. Parathyroid autotransplantation during thyroidectomy: is frozen section necessary? / C. Y. Lo, K. Y. Lam // Arch. Surg. – 1999. – Vol. 134. – P. 258-260.
  58. Unintentional parathyroidectomy during thyroidectomy / N. J. Lee [et al.] // Laryngoscope. – 1999. – Vol. 109. – P. 1238-1240.
  59. Total thyroidectomy and parathyroid autotransplantation for radiation associated thyroid cancer / E. Paloyan [et al.]; disc. R. E. Wilson // Surgery. – 1976. – Vol. 80. – P. 70-76.
  60. Ander, S. In situ preservation of the parathyroid glands during operations on the thyroid / S. Ander, K. Johansson, S. Smeds // Eur. J. Surg. – 1997. – Vol. 163. – P. 33-37.
  61. Human parathyroid blood supply determined by laser–Doppler flowmetry / K. Johansson [et al.] // World J. Surg. – 1994. – Vol. 18. – P. 417-420.
  62. Kuhel, W. I. Parathyroid biopsy to facilitate the preservation of functional parathyroid tissue during thyroidectomy / W. I. Kuhel, J. F. Carew // Head Neck. – 1999. – Vol. 21. – P. 442-446.
  63. Kao, P. C. Intraoperative monitoring of parathyroid hormone immunochemiluminometric assay / P. C. Kao, J. A. van Heerden, R. L. Taylor // Mayo Clinic Proc. – 1994. – Vol. 69. – P. 532-536.
  64. Lo, C. Y. Applicability of intraoperative parathyroid hormone assay during thyroidectomy / C. Y. Lo, J. M. Luk, S. C. Tam // Ann. Surg. – 2002. – Vol. 236. – P. 564-569.
Àäðåñ äëÿ êîððåñïîíäåíöèè:
220116, Ðåñïóáëèêà Áåëàðóñü, ã. Ìèíñê,ïð-ò. Äçåðæèíñêîãî, 83, Áåëîðóññêèé ãîñóäàðñòâåííûé ìåäèöèíñêèé óíèâåðñèòåò, 2-ÿ êàôåäðà õèðóðãè÷åñêèõ áîëåçíåé,
e-mail: vladimirkh77@mail.ru,
Õðûùàíîâè÷ Â.ß.
Êîíòàêòû | ©Âèòåáñêèé ãîñóäàðñòâåííûé ìåäèöèíñêèé óíèâåðñèòåò, 2007-2023