Year 2023 Vol. 31 No 4

REVIEWS

A.V. SAZHIN 1, T.V. NECHAY, S.I. PANIN 2, V.S. ZAMARAEV 2, N.A. SHCHERBAKOV 1, A.A. GOFMAN 1,
V.A. DONETSKOVA 1, A.G. YULDASHEV 1, A.A. KUZNETSOV 2

GENETIC PREDICTORS OF COLORECTAL ANASTOMOTIC FAILURE NEW HORIZONS OF PERSONALIZED SURGERY
OR UTOPIA? OVERVIEW OF THE SUBJECT FIELD

Pirogov Russian National Research Medical University 1, Moscow,
Volgograd State Medical University 2, Volgograd,
Russian Federation

Objective. To perform the analysis of genetic markers as possible predictors of colorectal anastomotic leakage.
Methods. A systematic search, selection and assessment of methodological quality of original primary studies published until April 2022 were carried out independently by co-authors in accordance with recommendations from Federal State Budgetary Institution Center for examination and quality control of medical care (Omelyanovsky V.V., 2019) and with the guidance of the Cochrane community (Higgins J. et al., 2022).
Results. This review shows possibility of evaluation of SNP signatures in risk stratification of colorectal anastomotic leakage. It was found out that anastomotic leakage in colonic surgery was statistically significant and was more frequent in group of patients with CC-genotype of genes encoding prostaglandin endoperoxide synthase 2 (PTGS2-765) and matrix metalloproteinase 2 (MMP2-1306) and GG genotype tissue inhibitor of metalloproteinase 2 (TIMP2-303). However, the nature and limited number of publishing primary studies bring the challenge to conduct mathematically determined meta-analysis of genetic polymorphisms underlying colon anastomotic leakage.
Conclusion. Obtained results may suggest a perspective direction of personalized studies in the field of prediction of anastomotic leakage in colonic surgery at the genome level.

Keywords: anastomotic leakage, personalized medicine, genetic markers
p. 332-339 of the original issue
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Address for correspondence:
117997, Russian Federation,
Moscow, Ostrovityanov st., 1,
Federal State Autonomous Educational Institution of Higher Education Russian National Research Medical University named after N.I. Pirogov
of the Ministry of Health of the Russian Federation, Department of Faculty Surgery No. 1 ,
tel.: +7 977 885-11-23,
e-mail: nikita.shche98@gmail.com,
Shcherbakov Nikita Alekseevich
Information about the authors:
Sazhin Alexander V., Corresponding Member of the Russian Academy of Sciences, MD, Professor, Director of the Research Institute of Clinical Surgery, Head of the Department of Faculty Surgery No. 1, Russian National Research Medical University. N.I. Pirogov, Moscow, Russian Federation. http://orcid.org/0000-0001-6188-6093
Nechay Taras V., MD, Associate Professor, Professor of the Department of Faculty Surgery No. 1, Russian National Research Medical University. N.I. Pirogova, Deputy Director of the Research Institute of Clinical Surgery, Moscow, Russian Federation.
http://orcid.org/0000-0003-0769-5282Associate Professor,
Panin Stanislav I., MD, Professor; Head of the Department of General Surgery, Volgograd State Medical University, Volgograd, Russian Federation.
http://orcid.org/0000-0003-4086-2054;
Zamaraev Valery S. MD, Professor, Professor of the Department of Microbiology, Virology, Immunology with a course of clinical microbiology, Volgograd State Medical University, Volgograd, Russian Federation. http://orcid.org/0000-0001-7442-9940;
Shcherbakov Nikita A., Resident of the Department of Faculty Surgery No. 1, Russian National Research Medical University. N.I. Pirogova, Laboratory Assistant at the Research Institute of Clinical Surgery, Moscow, Russian Federation.
http://orcid.org/0000-0002-5250-6359;
Gofman Anna A., Student, Laboratory Assistant at the Research Institute of Clinical Surgery, Moscow, Russian Federation.
http://orcid.org/0000-0002-8635-0786
Donetskova Victoria ., Student, Laboratory Assistant at the Research Institute of Clinical Surgery, Moscow, Russian Federation. http://orcid.org/0000-0003-2462-7556.
Yuldashev G. Anvarbek, PhD, Scientist at the Research Institute of Clinical Surgery, Moscow, Russian Federation.
http://orcid.org/0000-0002-1582-5350
Kuznetsov Alexander A., PhD, Associate Professor, Department of Urology, Volgograd State Medical University, Volgograd, Russian Federation. http://orcid.org/0000-0002-7026-1746;
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