Year 2022 Vol. 30 No 4

SCIENTIFIC PUBLICATIONS
EXPERIMENTAL SURGERY

T.N. TSERAKHAVA 1, I.O. POHODENKO-CHUDAKOVA 2, O.A. YUDINA 3, N. NIJIATI 1

EVALUATION OF THE EFFECTIVENESS OF THE STANDARD COMPLEX TREATMENT OF ACUTE PURULENT PERIOSTITIS OF THE MANDIBLE BASED ON MORPHOLOGICAL CHANGES IN EXPERIMENTAL CONDITIONS

Belarusian State Medical University, Minsk,
Republic of Belarus

Objective. The aim of the study is to determine the effectiveness of the standard complex treatment of acute purulent periostitis of the mandible on the basis of morphological changes in experimental conditions.
Methods. The study was performed on 47 rabbits (acute purulent periostitis of the lower jaw was simulated on 45). Series 1 12 animals that received only surgical treatment after the model was created. Series 2 7 animals that underwent surgery and received antibacterial therapy. Series 3 26 rabbits that were not treated. Series 4 served as a control and consisted of 2 animals without pathology. Micro-preparations were prepared according to the standard method. Morphological changes were evaluated in the analysis of periosteal pathology and expressed in points depending on their degree. The obtained data were processed statistically.
Results. The surgical method of treatment of periostitis in combination with antibiotic therapy made it possible to localize the inflammatory focus 2 days earlier than with isolated surgical treatment. An integrated approach contributed to optimization both in the focus of inflammation and in adjacent tissues. However, the prolonged persistence of inflammation was accompanied by reactive bone resorption and substitutive sclerosis which violated the anatomical relationship of structures in the area of examination.
Conclusion. Standard treatment of experimental acute purulent periostitis of the lower jaw does not give the desired result. It can lead to a chronic course of the disease and severe complications. This is the basis for the development of new complexes for its treatment.

Keywords: acute purulent periostitis, infectious and inflammatory process, morphological changes, standard treatment, experimental study
p. 340-350 of the original issue
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Address for correspondence:
220116, Republic of Belarus,
Minsk, Dzerzhinsky Ave., 83,
Educational institution
Belarusian State Medical University,
Department of Surgical Dentistry,
tel. +375 29 644 07 20,
e-mail: ip-c@yandex.ru,
Pokhodenko-Chudakova Irina O.
Information about the authors:
Terekhova Tamara N., MD, Professor, Professor of the Department of Pediatric Dentistry of the Educational Institution Belarusian State Medical University, Minsk, Republic of Belarus.
https://orcid.org/0000-0002-2647-5082
Pohodenko-Chudakova Irina O., MD, Head of the Department of Surgical Dentistry of the Educational Establishment Belarusian State Medical University, Minsk, Republic of Belarus.
https://orcid.org/0000-0002-0353-0125
Yudina Olga A., PhD, Associate Professor, Associate Professor of the Department of Pathological Anatomy of the Educational Establishment Belarusian State Medical University, Minsk, Republic of Belarus. https://orcid.org/0000-0001-7623-0601
Nizyati Nilupar, Post-Graduate Student of the Department of Pediatric Dentistry of the Educational Establishment Belarusian State Medical University, Minsk, Republic of Belarus.
https://orcid.org/0000-0003-4895-2281
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