Year 2021 Vol. 29 No 6




S.P. Grigoriev Institute of Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine 1,
Kharkiv National Medical University 2,
Kharkiv City Clinical Hospital No27 3,
Kharkiv State University named after V.N.Karazin 4, Kharkiv,
École Normale Supérieure 5, Lyon, France

Objective. Evaluate the potential long-term effects of differentiated thyroid cancer (DTC) treatment, on the gastro-intestinal tract (GIT) based on a retrospective study of DTC patients.
Methods. Occurrence of long-term GIT pathologies was retrospectively studied in 157 DTC patients. All patients were treated according to the standard of care, which includes radical surgery, radiation therapy and hormone therapy. The database contained digitalised medical histories of patients followed for at least 1 year after treatment. A total of 463 entries were available, representing one entry per noted consequence for each of the 157 patients. The study focused on two aspects. The frequencies of complications before and after treatment were compared, and factors impacting DTC pathology in a statistically significant manner were isolated.
Results: The total onset frequency of gallbladder, liver and pancreas disorders was increased by a factor of 1.6 in a statistically significant manner in DTC patients. Patients initially presenting gallbladder disorders received shorter cures of hormone therapy (4 versus 13 months), and lower levels of L-thyroxine in a context of uncompensated hypothyroidism (2.3 versus 3.5 mg/kg). A statistically significant relation was established between the total duration of breastfeeding in women presenting metabolic health disorders, and onset of liver pathology (essentially non-alcoholic steatohepatitis).
Conclusion. Life-long GIT pathology monitoring should be standard of care for patients after special DTC treatment.

Keywords: Differentiated thyroid cancer, long-term effects, gastro-intestinal tract disorders, hypothyroidism, L-thyroxine dose, metabolic health in women, breastfeeding duration
p. 719-727 of the original issue
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Address for correspondence:
61024, Ukraine,
Kharkiv, Pushkinskaya Str., 82,
S.P. Grigoriev Institute of Medical Radiology and Oncology, Group of Medical Information Technology,
tel. office.:+380 (67) 799-36-63,
Radzishevska Yevgenia B.
Information about the authors:
Radzishevska Yevgenia B., PhD (Phys., Biol. Science) Head of the Group of Medical Information Technology, S.P. Grigoriev Institute of Medical Radiology and Oncology, National Academy of Medical Sciences of Ukraine, Associate Professor of the Department of Medical Biological Physics and Medical Information Technology, Kharkiv National Medical University, Kharkiv, Ukraine.
Savchenko Antonina S., PhD, Associate Professor of the Department of Oncology, Radiology and Radiation Medicine, Kharkiv State University Named after V.N.Karazin, Radiologist of the Nuclear Medicine Department, S.P. Grigoriev Institute of Medical Radiology and Oncology, National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine.
Radzishevska Yaroslava K., PhD, Therapist, US Specialist, Kharkiv City Clinical Hospital No27, Kharkiv, Ukraine.
Vygivska Ludmila A., MD, Associate Professor of the Department of Obstetrics, Gynecology and Pediatric Gynecology, Kharkov National Medical University, Kharkiv, Ukraine.
Boiko Alexey N., PhD, Head of the Therapeutic Department, Kharkiv City Clinical Hospital No27, Kharkiv, Ukraine.
Kuksin M.S., Master of Biology, École Normale Supérieure. Higher School, Lyon, France.
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