Novosti
Khirurgii

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Year 2021 Vol. 29 No 6

ONCOLOGY

YEV.B. RADZISHEVSKA 1, 2, A.S. SAVCHENKO 1, 4, YA.K. RADZISHEVSKA 3, O.M. BOIKO 3, L.A. VYGIVSKA 2, M. KUKSIN 5

DEVELOPMENT OF REMOTE SEQUELAE SUCH AS GASTROINTESTINAL TRACT PATHOLOGY IN PATIENTS SPECIALLY TREATED FOR DIFFERENTIATED THYROID CANCER

S.P. Grigoriev Institute of Medical Radiology and Oncology of the National Academy of Medical Sciences of Ukraine 1,
Kharkiv National Medical University 2,
Kharkiv City Clinical Hospital No27 3,
Kharkiv State University named after V.N.Karazin 4, Kharkiv,
Ukraine
École Normale Supérieure 5, Lyon, France

Objective. Evaluate the potential long-term effects of differentiated thyroid cancer (DTC) treatment, on the gastro-intestinal tract (GIT) based on a retrospective study of DTC patients.
Methods. Occurrence of long-term GIT pathologies was retrospectively studied in 157 DTC patients. All patients were treated according to the standard of care, which includes radical surgery, radiation therapy and hormone therapy. The database contained digitalised medical histories of patients followed for at least 1 year after treatment. A total of 463 entries were available, representing one entry per noted consequence for each of the 157 patients. The study focused on two aspects. The frequencies of complications before and after treatment were compared, and factors impacting DTC pathology in a statistically significant manner were isolated.
Results: The total onset frequency of gallbladder, liver and pancreas disorders was increased by a factor of 1.6 in a statistically significant manner in DTC patients. Patients initially presenting gallbladder disorders received shorter cures of hormone therapy (4 versus 13 months), and lower levels of L-thyroxine in a context of uncompensated hypothyroidism (2.3 versus 3.5 mg/kg). A statistically significant relation was established between the total duration of breastfeeding in women presenting metabolic health disorders, and onset of liver pathology (essentially non-alcoholic steatohepatitis).
Conclusion. Life-long GIT pathology monitoring should be standard of care for patients after special DTC treatment.

Keywords: Differentiated thyroid cancer, long-term effects, gastro-intestinal tract disorders, hypothyroidism, L-thyroxine dose, metabolic health in women, breastfeeding duration
p. 719-727 of the original issue
References
  1. Pellegriti G, Frasca F, Regalbuto C, Squatrito S, Vigneri R. Worldwide increasing incidence of thyroid cancer: update on epidemiology and risk factors. J CancerEpidemiol. 2013;2013:965212. doi: 10.1155/2013/965212
  2. Dreval’ AV, Nechaeva OA, Garbuzov PI, Mamedova TR, Chikh ID, Krylov VV. Quality of life indices and psychoemotional status of the patients presenting with diffuse toxic goiter during the long-term follow-up after iodine radiotherapy. Problems of Endocrinology. 2013;59(3):13-18. doi: 10.14341/probl201359313-18c (In Russ.)
  3. Yoo SH, Choi-Kwon S. Changes in quality of life and related factors in thyroid cancer patients with radioactive iodine remnant ablation. J Korean Acad Nurs. 2013 Dec;43(6):801-11. doi: 10.4040/jkan.2013.43.6.801
  4. Parker WA, Edafe O, Balasubramanian SP. Long-term treatment-related morbidity in differentiated thyroid cancer: a systematic review of the literature. Pragmat Obs Res. 2017 May 16;8:57-67. doi: 10.2147/POR.S130510. eCollection 2017.
  5. Klein Hesselink EN, Klein Hesselink MS, deBock GH, Gansevoort RT, Bakker SJ, Vredeveld EJ, vander Horst-Schrivers AN, vander Horst IC, Kamphuisen PW, Plukker JT, Links TP, Lefrandt JD. Long-term cardiovascula rmortality in patients with differentiated thyroid carcinoma: anobservational study. J ClinOncol. 2013 Nov 10;31(32):4046-53. doi: 10.1200/JCO.2013.49.1043
  6. Abdulrahman RM, Delgado V, Hoftijzer HC, Ng AC, Ewe SH, Marsan NA, Holman ER, Hovens GC, Corssmit EP, Romijn JA, Bax JJ, Smit JW. Both exogenous subclinical hyperthyroidism and short-term overt hypothyroidism affect myocardial strain in patients with differentiated thyroid carcinoma. Thyroid. 2011 May;21(5):471-76. doi: 10.1089/thy.2010.0319
  7. Sawka AM, Lakra DC, Lea J, Alshehri B, Tsang RW, Brierley JD, Straus S, Thabane L, Gafni A, Ezzat S, George SR, Goldstein DP. A systematic review examining the effects of therapeutic radioactive iodine on ovarian function and future pregnancy in female thyroid cancer survivors. Clin Endocrinol (Oxf). 2008 Sep;69(3):479-90. doi: 10.1111/j.1365-2265.2008.03222.x
  8. Metso S, Jaatinen P, Huhtala H, Luukkaala T, Oksala H, Salmi J. Long-term follow-up study of radioiodine treatment of hyperthyroidism. Clin Endocrinol (Oxf). 2004 Nov;61(5):641-48. doi: 10.1111/j.1365-2265.2004.02152.x
  9. Zhang P, Xi H, Yan R. Effects of thyrotropin suppression on lumbar bone mineral density in postmenopausal women with differentiated thyroid carcinoma. Onco Targets Ther. 2018 Oct 9;11:6687-92. doi: 10.2147/OTT.S171282. eCollection 2018.
  10. Blackburn BE, Ganz PA, Rowe K, Snyder J, Wan Y, Deshmukh V, Newman M, Fraser A, Smith K, Herget K, Kim J, Kirchhoff AC, Porucznik C, Hanson H, Abraham D, Monroe M, Hashibe M. Reproductive and gynecological complication risks among thyroid cancer survivors. J Cancer Surviv. 2018 Oct;12(5):702-11. doi: 10.1007/s11764-018-0707-7
  11. Samadi R, Ghanbari M, Shafiei B, Gheibi S, Azizi F, Ghasemi A. High dose of radioactive iodine per se has no effect on glucose metabolism in thyroidectomized rats. Endocrine. 2017 May;56(2):399-407. doi: 10.1007/s12020-017-1274-9
  12. Lin SY, Hsu WH, Lin CL, Lin CC, Lin JM, Chang YL, Hsu CY, Kao CH. Evidence for an Association between Macular Degeneration and Thyroid Cancer in the Aged Population. Int J Environ Res Public Health. 2018 May 3;15(5):902. doi: 10.3390/ijerph15050902
  13. Wang S, Liang C, Zhao L, Meng Z, Zhang C, Jia Q, Tan J, Yang H, Liu X, Wang X. Influence of radioactive iodine therapy on liver function in patients with differentiated thyroid cancer. Nucl Med Commun. 2018 Dec;39(12):1113-20. doi: 10.1097/MNM.0000000000000919
  14. Rawson P, Stockum C, Peng L, Manivannan B, Lehnert K, Ward HE, Berry SD, Davis SR, Snell RG, McLauchlan D, Jordan TW. Metabolic proteomics of the liver and mammary gland during lactation. J Proteomics. 2012 Jul 19;75(14):4429-35. doi: 10.1016/j.jprot.2012.04.019
  15. Ajmera VH, Terrault NA, VanWagner LB, Sarkar M, Lewis CE, Carr JJ, Gunderson EP. Longer lactation duration is associated with decreased prevalence of non-alcoholic fatty liver disease in women. J Hepatol. 2019 Jan;70(1):126-32. doi: 10.1016/j.jhep.2018.09.013
  16. Velle-Forbord V, Skr åstad RB, Salvesen Ø, Kramer MS, Morken NH, Vanky E. Breastfeeding and long-term maternal metabolic health in the HUNT Study: a longitudinal population-based cohort study. BJOG. 2019 Mar;126(4):526-34. doi: 10.1111/1471-0528.15538
Address for correspondence:
61024, Ukraine,
Kharkiv, Pushkinskaya Str., 82,
S.P. Grigoriev Institute of Medical Radiology and Oncology, Group of Medical Information Technology,
tel. office.:+380 (67) 799-36-63,
e-mail: radzishevska@ukr.net,
Radzishevska Yevgenia B.
Information about the authors:
Radzishevska Yevgenia B., PhD (Phys., Biol. Science) Head of the Group of Medical Information Technology, S.P. Grigoriev Institute of Medical Radiology and Oncology, National Academy of Medical Sciences of Ukraine, Associate Professor of the Department of Medical Biological Physics and Medical Information Technology, Kharkiv National Medical University, Kharkiv, Ukraine.
https://orcid.org/0000-0001-9149-7689
Savchenko Antonina S., PhD, Associate Professor of the Department of Oncology, Radiology and Radiation Medicine, Kharkiv State University Named after V.N.Karazin, Radiologist of the Nuclear Medicine Department, S.P. Grigoriev Institute of Medical Radiology and Oncology, National Academy of Medical Sciences of Ukraine, Kharkiv, Ukraine.
https://orcid.org/0000-0002-7055-117X
Radzishevska Yaroslava K., PhD, Therapist, US Specialist, Kharkiv City Clinical Hospital No27, Kharkiv, Ukraine.
https://orcid.org/0000-0003-0770-3852
Vygivska Ludmila A., MD, Associate Professor of the Department of Obstetrics, Gynecology and Pediatric Gynecology, Kharkov National Medical University, Kharkiv, Ukraine.
https://orcid.org/0000-0002-9389-4845
Boiko Alexey N., PhD, Head of the Therapeutic Department, Kharkiv City Clinical Hospital No27, Kharkiv, Ukraine.
https://orcid.org/0000-0003-2865-2951
Kuksin M.S., Master of Biology, École Normale Supérieure. Higher School, Lyon, France.
https://orcid.org/0000-0001-8244-346X
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