This journal is
indexed in Scopus
Year 2020 Vol. 28 No 5
D.I. VARFOLOMEEV, V.G. SAMODAY
ASSESSMENT OF HIP JOINT SPACER FOR TREATING PATIENTS WITH PERIPROSTHETIC INFECTION
Voronezh State Medical University named after N.N. Burdenko, Voronezh,
Objective. Assessment of the possibility to use the developed spacer device while treating infectious complications after the hip replacement surgery.
Methods. The hip spacer has been developed to improve the outcomes of periprosthetic infection treatment. The spacer consists of the head, neck and a stem, made of bone cement. The carcass connected with the micropump is located inside it. The carcass is made in the form of four metal tubes which hold a liquid solution of drugs. The pump pistons are made of ferromagnet to interact with a magnet brought to the surface of the body. Drugs are released from the spacer under the external manetic field exposure in the postoperative period. The working spacer model was developed on the basis of the department of traumatology and orthopedics of Voronezh State Medical University named after N.N. Burdenko. Experimental studies on rabbits were conducted to evaluate the functionality of the spacer device. An implant containing Pyrogenalum solution was inserted in the abdominal cavity of animals under the intravenous anesthesia. In the test group the average temperature was estimated prior to and after the introduction of Pyrogenalum (under the magnetic field exposure).
Results. The temperature measured after the onset of the spacer operation differed trustworthy from those measured prior to the onset of the experiment (T-test – 17.17, p<0.05). This can be explained by the inoculation of Pyrogenalum contained in the spacer into the blood of animals. Experimental studies demonstrated the possibility of drugs release from the spacer into the wound under the magnetic field exposure on the spacer.
Conclusion. The proposed implant allows increasing the volume and quantity of drugs released from it into the wound. Surgeons can non-invasively control the rate of drugs inoculated directly into blood of the periprosthetic space in postoperative period. This provides the required concentration of drugs to help eradicate infection.
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394036, Russian Federation,
Voronezh, Studencheskaya str., 10,
Voronezh State Medical University
Named after N.N. Burdenko,
the Department of Traumatology and Orthopedics,
tel. +7 4732 57-96-67
Valery G. Samoday
Varfolomeev Denis I., Traumatologist-Orthopedist, Attendee of the Department of Traumatology and Orthopedics, Voronezh State Medical University Named after N.N. Burdenko, Voronezh, Russian Federation.
Samoday Valery G., MD, Professor, Head of the Department of Traumatology and Orthopedics, Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russian Federation.